This training program provides two years of basic research training in vascular surgery for academic clinicians and scientists. It addresses the absence of adequate research training for vascular surgeons as it applies to improving interventions and therapeutics of vascular disease. Research training in molecular and cell biology, biomechanics, coagulation thrombosis, angiogenesis and advanced outcomes research is provided with a focus on clinically relevant problems such as atherogenesis, intimal hyperplasia, prosthetic/host interactions and thrombosis. Trainees pursue a program of intense research activity supplemented with course work in research design, statistics, and evaluation of published research. The program is conducted and closely supervised by the program director, co-director and mentors who have well-established records of peer- reviewed research, and who were selected both for the current research activities and their proven commitment to train research fellows. Individual mentors are chosen from the program's faculty on the basis of the background and research interest of the individual trainee, and the trainees carry out their own projects under the close guidance of their mentor. Collaboration between laboratories and sharing of expertise is fostered. Laboratory training can be supplemented by graduate level training at Harvard Medical School, the Department of Health Care Policy and Research and Harvard's Faculty of Arts and Sciences, with course selection complementing laboratory endeavors. Upon completion of the program, trainees are capable of independent research and possess the scientific and research background needed to obtain competitive peer- reviewed grants;they have the abilities and knowledge necessary to provide translational expertise as they join medical school faculties. Selection of the trainees is based on candidates'demonstrated ability and career choice of academic practice and research. Applicants are resident physicians who have completed two, three or five years (i.e. board eligible) of post-graduate surgical training or those who have a PhD with zero to three years of postdoctoral experience. Trainees commit to two years of training;trainees desiring a shorter training period are not considered. Only those applicants with career goals as surgeon-scientists or scientists, with a keen interest in basic research or outcomes research related to vascular surgery, are compatible. Candidates pursuing a fellowship during a program of clinical training must provide evidence that they will be accepted back into that program upon completion of their research training. Trainees are not involved in any clinical activities unless research related.

Public Health Relevance

Vascular Surgeon-scientists guide and provide a practical hands on perspective on the relevant problems and limitations of devices and interventions on blood vessels. This T32 program creates a cadre of surgeon- scientists and scientists with expertise in research fundamentals essential to clinically driven frontline 'bench to bedside to public policy'programs in treatment of vascular disease.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007734-21A1
Application #
8741106
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02215
Ultee, Klaas H J; Zettervall, Sara L; Soden, Peter A et al. (2016) The impact of concomitant procedures during endovascular abdominal aortic aneurysm repair on perioperative outcomes. J Vasc Surg 63:1411-1419.e2
Moll, Herwig P; Lee, Andy; Peterson, Clayton R et al. (2016) A20 Haploinsufficiency Aggravates Transplant Arteriosclerosis in Mouse Vascular Allografts: Implications for Clinical Transplantation. Transplantation 100:e106-e116
Deery, Sarah E; Soden, Peter A; Zettervall, Sara L et al. (2016) Sex differences in mortality and morbidity following repair of intact abdominal aortic aneurysms. J Vasc Surg :
Lo, Ruby C; Schermerhorn, Marc L (2016) Abdominal aortic aneurysms in women. J Vasc Surg 63:839-44
Darling, Jeremy D; McCallum, John C; Soden, Peter A et al. (2016) Clinical results of single-vessel versus multiple-vessel infrapopliteal intervention. J Vasc Surg 64:1675-1681
Zettervall, Sara L; Soden, Peter A; Buck, Dominique B et al. (2016) Significant regional variation exists in morbidity and mortality after repair of abdominal aortic aneurysm. J Vasc Surg :
Zettervall, Sara L; Buck, Dominique B; Darling, Jeremy D et al. (2016) Increased preoperative pulse pressure predicts procedural complications and mortality in patients who undergo tibial interventions for critical limb ischemia. J Vasc Surg 63:673-7
Karthikesalingam, Alan; Vidal-Diez, Alberto; Holt, Peter J et al. (2016) Thresholds for Abdominal Aortic Aneurysm Repair in England and the United States. N Engl J Med 375:2051-2059
Zettervall, Sara L; Schermerhorn, Marc L; Soden, Peter A et al. (2016) The effect of surgeon and hospital volume on mortality after open and endovascular repair of abdominal aortic aneurysms. J Vasc Surg :
Soden, Peter A; Zettervall, Sara L; Ultee, Klaas H J et al. (2016) Patient selection and perioperative outcomes are similar between targeted and nontargeted hospitals (in the National Surgical Quality Improvement Program) for abdominal aortic aneurysm repair. J Vasc Surg :

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