African-Americans constitute approximately 14% of the US population. However, African-Americans have the highest incidence and death rates in cardiovascular diseases, lung diseases, cancer and blood-related diseases including sickle cell diseases in the nation. Also, African-Americans form less than 4% of all Biochemistry PhD degree graduates in this nation. Predoctoral research training in biomedical sciences with empahsis on biochemical approaches for studying human cardiovascular, blood and lung diseases offers a vital avenue for advancing the missions of NHLBI towards expansion of the underrepresented minority pool in the work force in these important areas. Therefore we are fully committed to the goals of NHLBI in changing this trend. The Biochemistry PhD program at Meharry Medical College plays significant roles in educating and graduating African Americans with PhD degrees in Biochemistry at a rate that sigificantly surpases the national average. Last year we awarded 3 African-Americans with PhD biochemistry degrees as compared to less than 0.4 per each US Biochemistry PhD degree program. This year we will graduate at least 4. This competing application seeks to continue this excellent work by recruting, training, nurturing, mentoring, and awarding at least six highly qualified minorities with Biochemistry PhD degrees. We are confident that our devoted, experienced and enthusiatic faculty from both Meharry Medical College and Vanderbilt University will provide the trainees with outstanding training through multi-disciplinary-based PhD education and training in Biochemistry as well as in Cancer Biology. We will achieve this goal through formal course work, seminars, works-in-progress, research training, enrichment workshops and effective mentoring. We plan to expouse our trainees to modern techniques and emerging techologies in biomedical sciences. We strongly believe that our program will ensure the students of excellent academic and research training in various research areas related to the mission of NHLBL/NIH. By accomplishing this goal our program will contribute significantly towards development of minitores for future careers in biomedical sciences in areas of that are realated to the pathogeneis and control of cardiovasuclar, pulmonary and hematological diseases.

Public Health Relevance

The relevance of this minority institution research training grant is in expansion of the minority pool in biomedical sciences by recruting, train and awarding minorities with PhD degrees in biomedical sciences in research related to the diseases of the cardiovascular, pulmonary and hematological systems.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007735-18
Application #
8294926
Study Section
Special Emphasis Panel (ZHL1-CSR-H (M2))
Program Officer
Chang, Henry
Project Start
1992-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
18
Fiscal Year
2012
Total Cost
$231,590
Indirect Cost
$13,263
Name
Meharry Medical College
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208
Pandhare, Jui; Addai, Amma B; Mantri, Chinmay K et al. (2014) Cocaine enhances HIV-1-induced CD4(+) T-cell apoptosis: implications in disease progression in cocaine-abusing HIV-1 patients. Am J Pathol 184:927-36
Thompson, Pamela D; Sakwe, Amos; Koumangoye, Rainelli et al. (2014) Alpha-2 Heremans Schmid Glycoprotein (AHSG) modulates signaling pathways in head and neck squamous cell carcinoma cell line SQ20B. Exp Cell Res 321:123-32
Goode, Gennifer D; Ballard, Billy R; Manning, H Charles et al. (2013) Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line. Int J Cancer 133:2769-80
Nangami, Gladys N; Watson, Kurt; Parker-Johnson, Kitani et al. (2013) Fetuin-A (*2HS-glycoprotein) is a serum chemo-attractant that also promotes invasion of tumor cells through Matrigel. Biochem Biophys Res Commun 438:660-5
Diggs, Deacqunita L; Myers, Jeremy N; Banks, Leah D et al. (2013) Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer. J Nutr Biochem 24:2051-63
Huderson, Ashley C; Myers, Jeremy N; Niaz, Mohammad S et al. (2013) Chemoprevention of benzo(a)pyrene-induced colon polyps in ApcMin mice by resveratrol. J Nutr Biochem 24:713-24
Bailey, Charvann K; Mittal, Mukul K; Misra, Smita et al. (2012) High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG. J Biol Chem 287:19472-86
Gadsden-Gray, Jessica; Mukherjee, Shyamali; Ogunkua, Olugbemiga et al. (2012) Induction of neuronal damage in guinea pig brain by intratracheal infusion of 2-chloroethyl ethyl sulfide, a mustard gas analog. J Biochem Mol Toxicol 26:23-30
Myers, Jeremy N; Rekhadevi, Perumalla V; Ramesh, Aramandla (2011) Comparative evaluation of different cell lysis and extraction methods for studying benzo(a)pyrene metabolism in HT-29 colon cancer cell cultures. Cell Physiol Biochem 28:209-18
Sakwe, Amos M; Koumangoye, Rainelli; Guillory, Bobby et al. (2011) Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions. Exp Cell Res 317:823-37

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