! This proposal is the fourth competing renewal of our Training Grant in Lung Science. During the last 18 and a half years, the Training Grant has provided 71 trainees the opportunity to develop strong foundations in lung science, including 42 MDs, 13 PhDs and 16 Predoctoral graduate students. Of the 12 predoctoral students who completed T32 support, three are in faculty positions, one is a staff scientist at CDC, seven are still in training and one is an industry scientist Among the 10 postdoctoral PhD trainees who no longer are T32-supported, four are in faculty positions, one is doing research with a Fogarty fellowship and three are research scientists in academics or industry. Eleven of the 18 MD postdoctoral trainees who received support entered academic faculty positions and ten remain as faculty. We have increased the inclusion of MD-PhD trainees and under-represented minorities supported by this grant. The three major aims of our Training Program are to: (1) provide 3 years of rigorous scientific training for physician-scientists, enabling them to become independent investigators examining scientific questions related to human lung disease;(2) provide up to 3 years of post-doctoral training to PhD scientists focusing their studies in lung biology and promoting long term careers in this field; and (3) train graduate students from the MD-PhD program and other established degree-granting programs - and guide them into careers in lung research. MD trainees are strongly encouraged to obtain advanced degrees to optimize their opportunities for a successful investigative career. The three major curricular areas encompassed by the program are: (1) Cell &Molecular Biology;(2) Systems Biology, Bioengineering;&Bio-Informatics;and (3) Clinical &Public Health Research. The curriculum provides formal training and degree opportunities for PhD degrees in Biochemistry, Molecular Biology &Biochemistry;Genetics, Cell Biology &Development;Microbiology, Immunology;&Cancer Biology;Bioengineering;Bioinformatics;for Masters degrees in Public Health or Clinical Research;or for Certificate Program in Clinical Research. The Training Faculty is drawn from 4 Academic Health Center colleges and the College of Science &Engineering. Faculty expertise extends across a broad spectrum, including: pulmonary fibrosis;lung injury;lung cancer;COPD; sleep medicine;asthma;cystic fibrosis;and bioethics. Comprehensive resources and stable research funding in each area provide an outstanding training environment.!
! ! ! This proposal is for continued funding of the Lung Biology Training program at the University Minnesota. This program provides three years of funding for eight postdoctoral MDs and PhDs to undertake an intensive state of the art research project supplemented by formal coursework and potentially while obtaining an advanced degree. It also supports training of four highly promising graduate students in lung biology while completing their thesis and obtaining their PhD. We offer outstanding multidisciplinary faculty trainers in three general domains: cell and molecular biology;systems biology, bioengineering and bio- informatics;and clinical and public health research. After completing this program, trainees should be ideally positioned to obtain a transitional career development grant that helps them obtain an academic faculty position.!
|Dillon, Nicholas A; Peterson, Nicholas D; Feaga, Heather A et al. (2017) Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA. Sci Rep 7:6135|
|Holguin, Fernando; Moughrabieh, M Anas; Ojeda, Victoria et al. (2017) Respiratory Health in Migrant Populations: A Crisis Overlooked. Ann Am Thorac Soc 14:153-159|
|Barnes, Aaron M T; Dale, Jennifer L; Chen, Yuqing et al. (2017) Enterococcus faecalis readily colonizes the entire gastrointestinal tract and forms biofilms in a germ-free mouse model. Virulence 8:282-296|
|Olson, Dalay H; Burrill, Joel S; Kuzmicic, Jovan et al. (2017) Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2). Biochem Biophys Res Commun 493:1311-1317|
|Flynn, Jeffrey M; Phan, Chi; Hunter, Ryan C (2017) Genome-Wide Survey of Pseudomonas aeruginosa PA14 Reveals a Role for the Glyoxylate Pathway and Extracellular Proteases in the Utilization of Mucin. Infect Immun 85:|
|Schuldt, Nathaniel J; Auger, Jennifer L; Spanier, Justin A et al. (2017) Cutting Edge: Dual TCR? Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation. J Immunol 199:33-38|
|Rosen, Brandon C; Dillon, Nicholas A; Peterson, Nicholas D et al. (2017) Long-Chain Fatty Acyl Coenzyme A Ligase FadD2 Mediates Intrinsic Pyrazinamide Resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother 61:|
|Chesner, Lisa N; Degner, Amanda; Sangaraju, Dewakar et al. (2017) Cellular Repair of DNA-DNA Cross-Links Induced by 1,2,3,4-Diepoxybutane. Int J Mol Sci 18:|
|Uchida, M; Anderson, E L; Squillace, D L et al. (2017) Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium. Allergy 72:1521-1531|
|Pragman, Alexa A; Berger, John P; Williams, Bryan J (2016) Understanding persistent bacterial lung infections: clinical implications informed by the biology of the microbiota and biofilms. Clin Pulm Med 23:57-66|
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