This application requests continued support for the highly successful postdoctoral training program in cardiovascular research in the Division of Cardiology at Emory University School of Medicine. The proposed program will extend our laboratory, translational and clinical research curriculum that has developed an impressive record of training outstanding postdoctoral fellows. The Emory University Cardiology Research Division has become recognized as a leader in research on the role of oxidative stress in vascular disease. The trainees of this program have been very successful in obtaining independent positions in academics. More than thirty graduates of our program are faculty members in American medical schools, and more than twenty have taken faculty positions in their home countries. We have had several trainees who have been winners or finalists for national young investigator awards. In the past 5 years, over 300 manuscripts from our recent trainees were published in peer-reviewed journals. This application for renewal of our Institutional National Research Service Award seeks funding for two full years of research training for eight post-doctoral trainees in the cardiovascular research program at Emory. Postdoctoral Ph.D. trainee applicants will join Emory for a defined, minimum two-year postdoctoral training period in our Research Scientist Pathway. Clinician scientist trainees are selected for one of two pathways that involve either a minimum two years of basic or clinical research, followed by two years of clinical cardiology training. The 29 mentors included in this application provide a broad-based, multidisciplinary environment ideally suited to provide an outstanding educational experience for trainees. Participating faculty are drawn from the Divisions/Departments of Cardiology, Medicine/lmmuology, Radiology, Public Health, Global Health and Biomedical Engineering at Emory University and Georgia Institute of Technology. All have established funding and publication records as well as documented success in training productive members of the scientific community. The training program is structured around a mentor-based environment supplemented with an extensive array of didactic educational opportunities. In summary, the proposed cardiovascular research training program will provide a unique opportunity for multidisciplinary training in basic and clinical cardiovascular research. Successful trainees will be well-equipped to initiate a research career in academic cardiology.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007745-20
Application #
8494660
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1994-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
20
Fiscal Year
2013
Total Cost
$288,015
Indirect Cost
$35,754
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Lee, Grace Sanghee; Salazar, Hector F; Joseph, Giji et al. (2018) Osteopontin isoforms differentially promote arteriogenesis in response to ischemia via macrophage accumulation and survival. Lab Invest :
Al-Badri, Ahmed; Hashmath, Zeba; Oldland, Garrett H et al. (2018) Poor Glycemic Control Is Associated With Increased Extracellular Volume Fraction in Diabetes. Diabetes Care 41:2019-2025
Kumar, Arnav; Hung, Olivia Y; Piccinelli, Marina et al. (2018) Low Coronary Wall Shear Stress Is Associated With Severe Endothelial Dysfunction in Patients With Nonobstructive Coronary Artery Disease. JACC Cardiovasc Interv 11:2072-2080
Forrester, Steven J; Kikuchi, Daniel S; Hernandes, Marina S et al. (2018) Reactive Oxygen Species in Metabolic and Inflammatory Signaling. Circ Res 122:877-902
Paredes, Felipe; Sheldon, Kely; Lassègue, Bernard et al. (2018) Poldip2 is an oxygen-sensitive protein that controls PDH and ?KGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer. Proc Natl Acad Sci U S A 115:1789-1794
Eshtehardi, Parham; Brown, Adam J; Bhargava, Ankit et al. (2017) High wall shear stress and high-risk plaque: an emerging concept. Int J Cardiovasc Imaging 33:1089-1099
Agarwal, Udit; George, Alex; Bhutani, Srishti et al. (2017) Experimental, Systems, and Computational Approaches to Understanding the MicroRNA-Mediated Reparative Potential of Cardiac Progenitor Cell-Derived Exosomes From Pediatric Patients. Circ Res 120:701-712
Virag, Lana; Wilson, John S; Humphrey, Jay D et al. (2017) Potential biomechanical roles of risk factors in the evolution of thrombus-laden abdominal aortic aneurysms. Int J Numer Method Biomed Eng 33:
Hansen, Laura M; Gupta, Divya; Joseph, Giji et al. (2017) The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice. Lab Invest 97:34-42
Ahn, Sung Gyun; Suh, Jon; Hung, Olivia Y et al. (2017) Discordance Between Fractional Flow Reserve and Coronary Flow Reserve: Insights From Intracoronary Imaging and Physiological Assessment. JACC Cardiovasc Interv 10:999-1007

Showing the most recent 10 out of 45 publications