This application is a competitive renewal of the present Multidisciplinary Training Program in Lung Disease (HL07749). The goal of the program is produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of pulmonary disorders. The program proposes to support 12 postdoctoral fellows (M.D.s and Ph.D.s) per year. The investigative approaches available to trainees include disciplines applicable at the molecular, cellular, tissue, organ, whole animal and clinical population levels. The program utilizes faculty trainers from the Medical School, School of Public Health, the Life Sciences Institute, and the College of Engineering at the Universityof Michigan. Medical School faculty trainers are appointed in the Departments of Internal Medicine, Pathology, Radiology, Human Genetics and Molecular and Integrative Physiology. The School of Public Health trainers are appointed in the Departments of Epidemiology and Biostatistics. The College of Engineering trainers are appointed in the Department of Biomedical Engineering. A close relationship between a primary mentor and a co-mentor(s) with the trainee is the core of the training experience. This laboratory experience is supplemented by a core group of lectures, formal course work, core conferences, and training in responsible research conduct, career planning, communication skills, and grant writing. Emphasis is placed on personal instruction specifically designed for individual trainees. New faculty and core lectures have been added to further solidify the disciplines of bioinformatics, genetics and nanobiology. Considerable emphasis has been placed on multidisciplinary interactions and providing opportunities to develop academic careers in areas of scientific need. Emerging areas of growth in our program include microbial pathogenesis, transplantation biology, progenitor cell biology, and multi-institutional disease-specific clinical networks for research. Postdoctoral trainees in the clinical sciences can acquire a Master's Degree from the School of Public Health. A broad range of research topics is available to trainees including chemokine biology, the pathobiology of fibrotic lung disease, host defense mechanisms, lymphocyte-macrophage interactions, epithelial cell biology, fibroblast biology, protease biology, eicosanoid biochemistry, granulocyte biology, progenitor cell biology, epidemiology, outcomes in lung disease, physician decision making, economic assessment of medical interventions, appropriate utilization of the medical technology and medical ethics. Fellows and mentors are reviewed by a committee that monitors the training and career development of fellows and promotes mentoring skills. The program has trained 5 minority trainees (all enrolled since 2004;4 are current trainees). Eighty percent (80%) of graduates trained in the past 10 years are currently in academic or equivalent positions, indicative of the program's success.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007749-19
Application #
8100180
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Colombini-Hatch, Sandra
Project Start
1993-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
19
Fiscal Year
2011
Total Cost
$785,153
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Sheth, Jamie S; Belperio, John A; Fishbein, Michael C et al. (2017) Utility of Transbronchial vs Surgical Lung Biopsy in the Diagnosis of Suspected Fibrotic Interstitial Lung Disease. Chest 151:389-399
Boorsma, Carian E; van der Veen, T Anienke; Putri, Kurnia S S et al. (2017) A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages. Sci Rep 7:12570
Govindan, Sushant; Prescott, Hallie C (2017) Quick Sequential Organ Failure Assessment: Illness Severity Indicator, Clinical Decision Support Tool, or Both? Crit Care Med 45:1947-1949
Roussey, Jonathan A; Viglianti, Steven P; Teitz-Tennenbaum, Seagal et al. (2017) Anti-PD-1 Antibody Treatment Promotes Clearance of Persistent Cryptococcal Lung Infection in Mice. J Immunol 199:3535-3546
Zhou, Xiaofeng; Moore, Bethany B (2017) Lung Section Staining and Microscopy. Bio Protoc 7:
Xu, Jintao; Flaczyk, Adam; Neal, Lori M et al. (2017) Exploitation of Scavenger Receptor, Macrophage Receptor with Collagenous Structure, by Cryptococcus neoformans Promotes Alternative Activation of Pulmonary Lymph Node CD11b+ Conventional Dendritic Cells and Non-Protective Th2 Bias. Front Immunol 8:1231
Neal, Lori M; Xing, Enze; Xu, Jintao et al. (2017) CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis. MBio 8:
Draijer, Christina; Peters-Golden, Marc (2017) Alveolar Macrophages in Allergic Asthma: the Forgotten Cell Awakes. Curr Allergy Asthma Rep 17:12
Fagerlin, Angela; Valley, Thomas S; Scherer, Aaron M et al. (2017) Communicating infectious disease prevalence through graphics: Results from an international survey. Vaccine 35:4041-4047
Sjoding, Michael W; Schoenfeld, David A; Brown, Samuel M et al. (2017) Power Calculations to Select Instruments for Clinical Trial Secondary Endpoints. A Case Study of Instrument Selection for Post-Traumatic Stress Symptoms in Subjects with Acute Respiratory Distress Syndrome. Ann Am Thorac Soc 14:110-117

Showing the most recent 10 out of 274 publications