This application is a competitive renewal of the present Multidisciplinary Training Program in Lung Disease (HL07749), which has been continuously funded since 1993. The goal of the program is produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of pulmonary disorders. The program proposes to support 12 postdoctoral fellows (M.D., Ph.D., and M.D./PhD.) per year. The investigative approaches available to trainees include disciplines applicable at the molecular, cellular, tissue, organ, whole animal and clinical population levels. The program is truly multidisciplinary, utilizing faculty trainers from the Medical School, School of Public Health, the College of Pharmacy, and the College of Engineering at the University of Michigan. A close relationship between a primary mentor and a co-mentor(s) with the trainee is the foundation of the training experience. This research experience is supplemented by a core group of lectures, workshops, core conferences, and training in responsible research conduct, career planning, communication skills, and grant writing. Emphasis is placed on personal instruction specifically designed for individual trainees. Faculty and core lectures have been added to further solidify the disciplines of bioinformatics, genetics/epigenetics, metabolomics, and the microbiome. Emerging areas of growth include host- microbe interactions, transplantation biology, regenerative medicine, precision medicine, data science, health services research and multi-institutional disease-specific clinical networks for research. Postdoctoral trainees can acquire Master's Degrees in Clinical Research Design and Statistical Analysis from the School of Public Health or health services research through the National Clinical Scholars Program in Health and Healthcare Research. A broad range of research topics is available to trainees including the pathobiology of acute and chronic lung disease, host defense mechanisms, progenitor cell biology, bioinformatics, long-term outcomes in lung disease and critical illness, physician decision making, cost/benefit analysis, application of medical technology and implementation science. Fellows and mentors are reviewed by a committee that monitors the training and career development of fellows. Eight underrepresented minorities have completed our training program over the past 10 years. Ninety percent of graduates trained in the past 15 years are in academic or industry positions, indicative of the program's success.

Public Health Relevance

The University of Michigan Multidisciplinary Training Program in Lung Disease provides research training for M.D. and Ph.D. scientists in both laboratory-based and clinical studies. The purpose of this training is to produce outstanding biomedical scientists who investigate the manifestations, mechanisms, prevention, and treatment of lung disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007749-26
Application #
9417125
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Kalantari, Roya
Project Start
1993-07-01
Project End
2023-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
26
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Labaki, Wassim W; Han, MeiLan K (2018) Impact of bronchiectasis on the frequency and severity of respiratory exacerbations in COPD. Int J Chron Obstruct Pulmon Dis 13:2335-2338
Dickson, Robert P; Erb-Downward, John R; Falkowski, Nicole R et al. (2018) The Lung Microbiota of Healthy Mice Are Highly Variable, Cluster by Environment, and Reflect Variation in Baseline Lung Innate Immunity. Am J Respir Crit Care Med 198:497-508
Bailoor, Kunal; Valley, Thomas; Perumalswami, Chithra et al. (2018) How acceptable is paternalism? A survey-based study of clinician and nonclinician opinions on paternalistic decision making. AJOB Empir Bioeth 9:91-98
Denstaedt, Scott J; Spencer-Segal, Joanna L; Newstead, Michael W et al. (2018) S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis. J Immunol 200:3188-3200
Singer, Benjamin H; Dickson, Robert P; Denstaedt, Scott J et al. (2018) Bacterial Dissemination to the Brain in Sepsis. Am J Respir Crit Care Med 197:747-756
Iwashyna, Theodore J; Viglianti, Elizabeth M (2018) Patient and Population-Level Approaches to Persistent Critical Illness and Prolonged Intensive Care Unit Stays. Crit Care Clin 34:493-500
Sjoding, Michael W; Hofer, Timothy P; Co, Ivan et al. (2018) Interobserver Reliability of the Berlin ARDS Definition and Strategies to Improve the Reliability of ARDS Diagnosis. Chest 153:361-367
Labaki, Wassim W; Xia, Meng; Murray, Susan et al. (2018) NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort. Respir Med 140:87-93
Vasilevskis, Eduard E; Chandrasekhar, Rameela; Holtze, Colin H et al. (2018) The Cost of ICU Delirium and Coma in the Intensive Care Unit Patient. Med Care 56:890-897
Penke, Loka R; Speth, Jennifer M; Dommeti, Vijaya L et al. (2018) FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis. J Clin Invest 128:2389-2405

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