This multidisciplinary training program based in the Sol Sherry Thrombosis Research Center, and Departments of Biochemistry, Physiology, Pharmacology, Microbiology and Immunology, Biology, and the Fels Institute for Cancer Research and Molecular Biology, provides a rich and varied research environment for predoctoral and postdoctoral trainees as well as short-term medical student trainees and post-baccalaureate students. The goal is to develop highly competent investigators capable of performing and eventually directing clinical and basic research in thrombosis, hemostasis, and vascular biology. Multi-department participation provides trainees with a choice of directions in which to continue and extend the scope of their research while remaining highly focused in their goals. Trainees are exposed to a wide variety of perspectives, ideas, and methodologies that can be utilized in their dissertation research, postdoctoral training and careers as investigators. Research training, primarily of the preceptor type, with active participation of Research Advisory Committees of the graduate students, integrates research faculty in various disciplines to emphasize application of modern techniques toward the solution of important problems related to hemostatic, thrombotic, and vascular disorders. Rigorous training is provided in such disciplines as cell and molecular biology, biochemistry, and immunology in the solution of problems in coagulation, platelet physiology, vascular biology and inflammation. Predoctoral students must complete a rigorous series of graduate courses giving them a thorough background in basic science disciplines. First-year students must complete broad didactic graduate courses followed by more specialized and detailed second level courses, followed by advanced elective courses, seminars by outside speakers and faculty, and by journal club participation. Students are also required to complete rotations in laboratories with diverse interests to expose them to various methodologies and experimental approaches. Applicants for the predoctoral program must have a Bachelor's degree from an accredited institution and must have a solid background in the biological and chemical sciences, including the successful completion of advanced courses (e.g., biochemistry or immunology). Previous research experience is desirable. Only full-time students are accepted. Grade point average, GRE scores, letters of recommendation, and an interview are all important criteria. Postdoctoral applicants must have received a Ph.D., M.D., or D.V.M. degree. Each training program will depend on past research and educational : experience. State-of-the-art equipment and services are available within and outside of the Center.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007777-20
Application #
8319430
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
1993-07-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
20
Fiscal Year
2012
Total Cost
$374,055
Indirect Cost
$35,930
Name
Temple University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Wang, Qizhao; Dong, Biao; Firrman, Jenni et al. (2014) Efficient production of dual recombinant adeno-associated viral vectors for factor VIII delivery. Hum Gene Ther Methods 25:261-8
Mondrinos, Mark J; Zhang, Ting; Sun, Shuang et al. (2014) Pulmonary endothelial protein kinase C-delta (PKCýý) regulates neutrophil migration in acute lung inflammation. Am J Pathol 184:200-13
Kong, Weimin; Li, Hongbo; Tuma, Ronald F et al. (2014) Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS. Cell Immunol 287:1-17
Kostyak, John C; Bhavanasi, Dheeraj; Liverani, Elisabeta et al. (2014) Protein kinase C ? deficiency enhances megakaryopoiesis and recovery from thrombocytopenia. Arterioscler Thromb Vasc Biol 34:2579-85
Liverani, Elisabetta; Rico, Mario C; Garcia, Analia E et al. (2013) Prasugrel metabolites inhibit neutrophil functions. J Pharmacol Exp Ther 344:231-43
Mondrinos, Mark J; Kennedy, Paul A; Lyons, Melanie et al. (2013) Protein kinase C and acute respiratory distress syndrome. Shock 39:467-79
Dong, Biao; Moore, Andrea R; Dai, Jihong et al. (2013) A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy. Nucleic Acids Res 41:6609-17
Getz, Todd M; Manne, Bhanu Kanth; Buitrago, Lorena et al. (2013) Dextran sulphate induces fibrinogen receptor activation through a novel Syk-independent PI-3 kinase-mediated tyrosine kinase pathway in platelets. Thromb Haemost 109:1131-40
Garcia, Analia E; Rico, Mario C; Liverani, Elisabetta et al. (2013) Erosive arthritis and hepatic granuloma formation induced by peptidoglycan polysaccharide in rats is aggravated by prasugrel treatment. PLoS One 8:e69093
Manne, Bhanu Kanth; Getz, Todd M; Hughes, Craig E et al. (2013) Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2). J Biol Chem 288:7717-26

Showing the most recent 10 out of 60 publications