This is a competing renewal of a training program designed to prepare highly qualified postdoctoral fellows for research careers in respiratory biology and disease pathogenesis. In this program, we will encourage applications of MD and PhD candidates from various sources (Clinical &Basic Science Departments) emphasizing a nationwide competition. MD trainees are allowed to enter this program only after having completed the clinical requirements for Board eligibility. Optimal research training is achieved by protecting the trainees'time to allow their efforts to be dedicated to research. Training is mentor-based and is enriched by didactic courses and by interactions with a broadly-based faculty. The faculty were chosen based on ongoing research productivity, significant extramural support, and availability and commitment to serve as mentors. They also belong to research spheres identified as important in respiratory disease processes: including cell biology, molecular biology, genetics, immunology, inflammation, tissue remodeling, clinical epidemiology, biostatistics, and translational biology. Because of the wide spectrum of strong laboratories at Yale and the institutional nature of this proposal, 8 postdoctoral positions are requested per year. The duration of the program will be a minimum of 2 years. Trainee progress will be carefully evaluated and productivity monitored by each mentor, a Training Advisory Committee, and the Program Directors. The uniqueness of this program stems from a) the truly institutional nature of this grant involving 3 Schools, 3 Clinical Departments (Pediatrics, Internal Medicine and Psychiatry) and 10 Basic Science Departments;b) the strong interactions that exist between the clinical and basic science faculty on this program;and c) the training track record of the resource faculty. Through this program we expect to entice, train, and prepare future leaders in pulmonary research in academic pediatrics, internal medicine, and basic science arenas.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Tigno, Xenia
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Internal Medicine/Medicine
Schools of Medicine
New Haven
United States
Zip Code
Jafari, Behrouz; Elias, Jack A; Mohsenin, Vahid (2014) Increased plasma YKL-40/chitinase-3-like-protein-1 is associated with endothelial dysfunction in obstructive sleep apnea. PLoS One 9:e98629
Sauler, Maor; Leng, Lin; Trentalange, Mark et al. (2014) Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 306:L487-96
Britto, Clemente J; Liu, Qing; Curran, David R et al. (2013) Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity. Am J Respir Cell Mol Biol 48:717-24
Walker, Wendy E; Booth, Carmen J; Goldstein, Daniel R (2010) TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA. Mol Ther 18:775-84
Walker, Wendy E; Goldstein, Daniel R (2009) B cells are dispensable for neonatal transplant tolerance induction. Transplantation 88:874-8
Mohsenin, Vahid; Yaggi, H Klar; Shah, Neomi et al. (2009) The effect of gender on the prevalence of hypertension in obstructive sleep apnea. Sleep Med 10:759-62
Ramana, Chilakamarti V; Cheng, Guang-Shing; Kumar, Aseem et al. (2009) Role of alveolar epithelial early growth response-1 (Egr-1) in CD8+ T cell-mediated lung injury. Mol Immunol 47:623-31
Tesar, B M; Du, W; Shirali, A C et al. (2009) Aging augments IL-17 T-cell alloimmune responses. Am J Transplant 9:54-63
Botros, Nader; Concato, John; Mohsenin, Vahid et al. (2009) Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med 122:1122-7
Stout-Delgado, Heather W; Yang, Xin; Walker, Wendy E et al. (2008) Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J Immunol 181:6747-56

Showing the most recent 10 out of 20 publications