The purpose of this program is to train scientists for careers in hematological research. The primary focus is on the cellular physiology of the hematopoietic, immune and hemostatic systems, but extends to related areas of developmental and cellular hematology, leukemia pathogenesis, hematopoietic development, cellular biology of iron metabolism, viral pathogenesis, cell growth signaling, genomic instability, and experimental therapeutics. The program is administered through the Divisions of Hematology and Medical Oncology and Molecular Medicine, which constitute the major laboratory research areas of the Department of Internal Medicine, and includes other Departmental units within OHSU that participate in the large and interactive Oregon Cancer Institute. The training faculty consists of 33 members from the Departments of Medicine, Pediatrics, Microbiology and Immunology, Biochemistry and Molecular Biology, Cell and Developmental Biology and the Vollum Institute. Training in translational research is closely allied with clinical activities of the OHSU University Hospital, Portland VA Medical Center and the Center for Hematologic Malignancies, which specializes in bone marrow transplantation and leukemia management. The increasing number of clinician scientists and basic scientists in hematology at OHSU provides an outstanding environment for our graduate and postgraduate trainees.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Maxson, Julia E; Luty, Samuel B; MacManiman, Jason D et al. (2014) Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization. J Biol Chem 289:5820-7
Owen, Nichole; Hejna, James; Rennie, Scott et al. (2014) Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM. Cytogenet Genome Res 144:255-63
Gotlib, Jason; Maxson, Julia E; George, Tracy I et al. (2013) The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment. Blood 122:1707-11
Fleischman, Angela G; Maxson, Julia E; Luty, Samuel B et al. (2013) The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition. Blood 122:3628-31
Garbati, Michael R; Hays, Laura E; Keeble, Winifred et al. (2013) FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1* in macrophages. Blood 122:3197-205
Zachman, Derek K; Leon, Ronald P; Das, Prerna et al. (2013) Endothelial cells mitigate DNA damage and promote the regeneration of hematopoietic stem cells after radiation injury. Stem Cell Res 11:1013-21
Rowe, Alexander M; Murray, Susan E; Raue, Hans-Peter et al. (2013) A cell-intrinsic requirement for NF-*B-inducing kinase in CD4 and CD8 T cell memory. J Immunol 191:3663-72
Maxson, Julia E; Gotlib, Jason; Pollyea, Daniel A et al. (2013) Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med 368:1781-90
Aslan, J E; McCarty, O J T (2013) Rho GTPases in platelet function. J Thromb Haemost 11:35-46
Farrington, Lila A; Smith, Tameka A; Grey, Finn et al. (2013) Competition for antigen at the level of the APC is a major determinant of immunodominance during memory inflation in murine cytomegalovirus infection. J Immunol 190:3410-6

Showing the most recent 10 out of 52 publications