The "Experimental therapeutics in critical care" postdoctoral training program proposal is designed to support a 5-year continuation of our existing multidisciplinary research training program. This proposal trains fellows, for a period of 2 or 3 years each, in the science of organ dysfunction and its consequences in critical illness. Funds to support 4 fellows for all years are requested. The overall research focus of the trainees is the biology of acute severe illness and its response to therapy in 3 inter-related levels of investigation: 1) Immunobiology and Cellular Basis for Organ Injury;2) Organ-systems Modeling;and 3) Clinical and Health Services Research. This approach underscores the essential basis of critical care medicine, requiring an integration of cell and molecular biology t organ-system monitoring, and therapies to define their effects on socially relevant outcomes. These research areas coincide with extramural research grants of the training faculty. The research plans are excellent vehicles for training because they ask broad questions on which precise, well-targeted individual research training efforts can be staged. The faculty are an experienced and dedicated group of federally-funded senior academicians. Upon completion of the training program, the fellow will understand how to design, execute, and complete experiments to answer specific questions derived from critically ill patients. Thus, the fellow wil be also trained in the thought processes needed to apply these tools in the future as they relate to real life problems in critically ill patients. All trainees will take formal postgraduate course offered by the University of Pittsburgh and the year-long "Responsible Conduct in Research" program including small group discussion session. Some trainees may complete coursework necessary to receive PhD or MPH degrees. Most training will take place in the laboratories of the principal trainers using a carefully thought-out version of the time-honored master-apprentice system. This training technique combines weekly meetings between the trainee and trainer as well as weekly hour-long research training seminars at which the trainer group, including of the principal trainer and other research trainers, whose special skills and interests are chosen to supplement the principal trainer, concurrently guide and monitor the trainee's research program. Furthermore, formal research presentations by the trainees are given biannually to our formal Clinical Research, Investigation and Systems Modeling of Acute Illness (CRISMA) research community. This flexible but intense degree of supervision permits the simultaneous completion of efficient, cordial, and cooperative research and training. Individual fellows choose a principal trainer with the support and guidance of the Executive Training Committee. They collectively fashion an individualized training program, trainer group, and coursework program to allow the fellow to accomplish the educational and research goals of their program. Affirmative action recruitment efforts are already in place and effective. The training facilities can serve more fellows than will be funded by this proposal and all training wil be carried out in our fully equipped facilities.

Public Health Relevance

This postdoctoral training program proposal entitled Experimental therapeutics in critical care is designed to support the salaries of 4 fellows for 2 to 3 years each over 5 year in the multidisciplinary research fields linked to acute severe illness. With most people in the US personally knowing someone who has been in an intensive care unit and with the high costs and mortalities associated with critical illness and its treatment, this program will produce graduate translational researchers able to apply the learning to future real life problems in critically ill patients with the goal of improving these patients'long-term outcomes. Most training will take place in the laboratories of the federally-funded principal trainers using a carefully thought-out version of the time-honored master-apprentice system coupled with formal coursework and weekly participatory research meetings.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Wang, Wayne C
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University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
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Costa, Deena Kelly; Barg, Frances K; Asch, David A et al. (2014) Facilitators of an interprofessional approach to care in medical and mixed medical/surgical ICUs: a multicenter qualitative study. Res Nurs Health 37:326-35
Pinsky, Michael R (2014) It is amazing what you can see if you look. J Clin Monit Comput 28:221-2
Pinsky, Michael R (2014) My paper 20 years later: Effect of positive end-expiratory pressure on right ventricular function in humans. Intensive Care Med 40:935-41
Zhou, Feihu; Peng, Zhi-Yong; Bishop, Jeffery V et al. (2014) Effects of fluid resuscitation with 0.9% saline versus a balanced electrolyte solution on acute kidney injury in a rat model of sepsis*. Crit Care Med 42:e270-8
Kelly, Deena M; Kutney-Lee, Ann; McHugh, Matthew D et al. (2014) Impact of critical care nursing on 30-day mortality of mechanically ventilated older adults. Crit Care Med 42:1089-95
Paladino, Jonathan D; Crooke, Philip S; Brackney, Christopher R et al. (2013) Medical practices display power law behaviors similar to spoken languages. BMC Med Inform Decis Mak 13:102
Kelly, Deena; Kutney-Lee, Ann; Lake, Eileen T et al. (2013) The critical care work environment and nurse-reported health care-associated infections. Am J Crit Care 22:482-8
Salonia, Rosanne; Bell, Michael J; Kochanek, Patrick M et al. (2012) The utility of near infrared spectroscopy in detecting intracranial hemorrhage in children. J Neurotrauma 29:1047-53
Simon, Peter M; Delude, Russell L; Lee, MinJae et al. (2011) Duration and magnitude of hypotension and monocyte deactivation in patients with community-acquired pneumonia. Shock 36:553-9
Mayr, Florian B; Yende, Sachin; D'Angelo, Gina et al. (2010) Do hospitals provide lower quality of care to black patients for pneumonia? Crit Care Med 38:759-65

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