This is a competitive renewal of a T32 training grant at the University of Colorado to support the training of post-doctoral fellows (MD and PhD) who wish to prepare for careers in cardiovascular research. The broad objective of this training program is to create a training environment that will provide the next generation of cardiovascular researchers with an appreciation of the linked research goals of the NIH/NHLBI strategic plan: To understand the molecular and physiologic basis of cardiovascular health and disease; To develop personalized preventive and therapeutic regimens for organ specific diseases and To generate an improved understanding of the processes involved in translating research into practice. To meet this objective, we have developed a comprehensive training plan and we have assembled a group of mentors from the rich cardiovascular research community at the University of Colorado campuses in Denver and Boulder. The specific goals of the training program are: To assemble a group of established and junior scientists with a shared commitment to the training of the next generation of cardiovascular investigators. Focus areas of investigation subserved by the trainers is consistent with the NIH/NHLBI strategic plan and includes faculty with an interest in basic biology of the cardiac myocyte and the vasculature;integrative and human physiology;and health services and outcomes research. To implement a recruitment strategy that will allow us to attract top MD, MD-PhD, and PhD candidates, including graduates of our clinical and basic science training programs, in order to provide them with cross disciplinary training in cardiovascular research that will prepare them for future academic careers. To develop a program of didactics and a multi-tiered mentoring process designed specifically for trainees supported by this grant that includes: topics in cardiovascular science;a hands-on mini- course focused on cardiovascular imaging and integrated physiology;participation in degree granting programs (PhD and/or MSPH) in both Health Services Research and Health Information Technology;and a mentoring program that will provide trainees with on-going scientific mentorship and career guidance

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Colorado Denver
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Schuetze, Katherine B; McKinsey, Timothy A; Long, Carlin S (2014) Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs. J Mol Cell Cardiol 70:100-7
Williams, Sarah M; Golden-Mason, Lucy; Ferguson, Bradley S et al. (2014) Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes. J Mol Cell Cardiol 67:112-25
Demos-Davies, Kimberly M; Ferguson, Bradley S; Cavasin, Maria A et al. (2014) HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling. Am J Physiol Heart Circ Physiol 307:H252-8
Ferguson, Bradley S; Harrison, Brooke C; Jeong, Mark Y et al. (2013) Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A 110:9806-11
Spiltoir, Jessica I; Stratton, Matthew S; Cavasin, Maria A et al. (2013) BET acetyl-lysine binding proteins control pathological cardiac hypertrophy. J Mol Cell Cardiol 63:175-9
Kao, David P; Hsich, Eileen; Lindenfeld, JoAnn (2013) Characteristics, adverse events, and racial differences among delivering mothers with peripartum cardiomyopathy. JACC Heart Fail 1:409-16
Kao, David; Bucher Bartelson, Becki; Khatri, Vaishali et al. (2013) Trends in reporting methadone-associated cardiac arrhythmia, 1997-2011: an analysis of registry data. Ann Intern Med 158:735-40
Kao, David P; Davis, Gordon; Aleong, Ryan et al. (2013) Effect of bucindolol on heart failure outcomes and heart rate response in patients with reduced ejection fraction heart failure and atrial fibrillation. Eur J Heart Fail 15:324-33
Luczak, Elizabeth D; Barthel, Kristen K B; Stauffer, Brian L et al. (2011) Remodeling the cardiac transcriptional landscape with diet. Physiol Genomics 43:772-80
Harvey, Pamela A; Leinwand, Leslie A (2011) The cell biology of disease: cellular mechanisms of cardiomyopathy. J Cell Biol 194:355-65

Showing the most recent 10 out of 11 publications