This is a competitive renewal of a T32 training grant at the University of Colorado to support the training of post-doctoral fellows (MD and PhD) who wish to prepare for careers in cardiovascular research. The broad objective of this training program is to create a training environment that will provide the next generation of cardiovascular researchers with training in cardiovascular research that is linked to the research goals of the NIH/NHLBI strategic plan: 1. to understand the molecular and physiologic basis of cardiovascular health and disease;2. to develop personalized preventive and therapeutic regimens for organ specific diseases and 3. to generate an improved understanding of the processes involved in translating research into practice. To meet this objective, we have developed a comprehensive training plan and we have assembled a group of mentors from the rich cardiovascular research community at the University of Colorado campuses in Denver and Boulder. The specific goals of the training program are: 1. To assemble a group of established scientists with a shared commitment to the training of the next generation of cardiovascular investigators. Focus areas of investigation sub served by the trainers is consistent with the NIH/NHLBI strategic plan and includes faculty with an interest in basic biology of the cardiac myocyte and the vasculature;integrative and human physiology;and health services and outcomes research. 2. To implement a recruitment strategy that will allow us to attract top MD, MD-PhD, and PhD candidates, including graduates of our clinical and basic science training programs especially those from underserved minority groups, in order to provide them with cross disciplinary training in cardiovascular research that will prepare them for future academic careers. 3. To develop a program of didactics and a multi-tiered mentoring process designed specifically for trainees supported by this grant that includes: topics in cardiovascular science and entrepreneurship;a hands-on mini-course focused on techniques in cardiovascular research;participation in degree granting programs (PhD and/or MSPH) in both Health Services Research and Health Information Technology;and a mentoring program that will provide trainees with on-going scientific mentorship and career guidance

Public Health Relevance

Despite substantial diagnostic and therapeutic advances, cardiovascular disease remains the leading cause of death in western society, This fact speaks to the overwhelming need to focus the next generation of clinicians and scientists on this health concern, not only at the level of basic cell biology, but also as it impacts the entire organism and society at large. This integrated approach to training is central to this training grant.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Colorado Denver
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Soto, Susan M; Blake, Amy C; Wesolowski, Stephanie R et al. (2017) Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol 232:475-491
Dittmer, Philip J; Wild, Angela R; Dell'Acqua, Mark L et al. (2017) STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep 19:321-334
Stratton, Matthew S; Koch, Keith A; McKinsey, Timothy A (2017) p38?: A Profibrotic Signaling Nexus. Circulation 136:562-565
Schuetze, Katherine B; Stratton, Matthew S; Blakeslee, Weston W et al. (2017) Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts. J Pharmacol Exp Ther 361:140-150
Ackerman, Jaeger P; Bartos, Daniel C; Kapplinger, Jamie D et al. (2016) The Promise and Peril of Precision Medicine: Phenotyping Still Matters Most. Mayo Clin Proc :
Kao, David P; Lindenfeld, JoAnn; Macaulay, Dendy et al. (2016) Impact of a Telehealth and Care Management Program on All-Cause Mortality and Healthcare Utilization in Patients with Heart Failure. Telemed J E Health 22:2-11
Valle, Javier A; O'Donnell, Colin I; Armstrong, Ehrin J et al. (2016) Guideline Recommended Medical Therapy for Cardiovascular Diseases in the Obese: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking (CART) Program. J Am Heart Assoc 5:
Schuetze, Katherine B; Koch, Keith A; McKinsey, Timothy A (2016) The potential of targeting epigenetic regulators for the treatment of fibrotic cardiac diseases. Future Med Chem 8:1533-6
Touat-Hamici, Zahia; Weidmann, Henri; Blum, Yuna et al. (2016) Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function. Cardiovasc Res 112:702-713
Brunt, Vienna E; Jeckell, Andrew T; Ely, Brett R et al. (2016) Acute hot water immersion is protective against impaired vascular function following forearm ischemia-reperfusion in young healthy humans. Am J Physiol Regul Integr Comp Physiol 311:R1060-R1067

Showing the most recent 10 out of 79 publications