This competitive renewal of the Molecular and Cellular Cardiology Training Program (MCCTP) housed at the Icahn School of Medicine at Mount Sinai School (ISMMS) emphasizes not only training post-doctoral scientists but also on fostering their development as independent researchers. The Co-PIs, Dr. Roger J. Hajjar and Dr. Bruce Gelb are renowned physician-scientists with exceptional credentials as investigators and mentors. Cardiovascular disease with its associated morbidity and morality remains a health care problem. Our ability to understand cellular and molecular underpinnings of cardiac pathologies is imperative towards the design of new and effective treatment strategies. Progress has been driven in part by technological advances in molecular biology, genomics and imaging. Our primary goal is to produce the next generation of translational investigators and clinician/scientists and to create an environment that will nurture their professional development. The Cardiovascular Research Center (CVRC) and the myriad of translational research institutes available on the ISMMS campus afford trainees with access to state-of-the-art research and core facilities. Training positions are available to both physician-scientists and Ph.D. post-doctoral fellows. We have a defined selection process specific to each applicant type. Physician-scientist applicants to ISMMS clinical cardiology fellowship program and who agree to spend a minimum of three years full-time in the laboratory (optimally 4-5 years) will be given priority. For Ph.D. post-doctoral fellows, selection will be based on past research track experiences, demonstrated tangible productivity and a commitment to pursue an investigative career focused in cardiovascular research. All MCCTP applicants will be required to complete a questionnaire in which they will detail career aspirations, accomplishments and future plans. The MCCTP possesses an accomplished faculty. Laboratory-based training is focused in seven thematic areas central to translational cardiovascular research: vascular biology and imaging, myocardial disease and heart failure, genetics and development, electrophysiology, metabolic diseases and diabetes, stem cell and gene therapies, and systems biology. MCCTP trainees will participate in a weekly cardiovascular research seminar as well as have access to course offerings through the Mount Sinai Graduate School of Biomedical Sciences. Trainee progress will be evaluated annually using well-defined criteria for professional career advancement. An addition to the MCCTP is the integration of a highly successful program focused on preparing postdoctoral fellowship and NIH K award proposals. Trainees will also have opportunities to interact with established investigators and past trainees who have advanced through the MCCTP. Each trainee in conjunction with their primary mentor will prepare an Individual Development Plan (IDP) that will be evaluated by the Career Development director. Internal and external advisory committees will evaluate the program based on benchmark criteria such as, trainee progress, recruitment success, extramural funding and career paths of former trainees.

Public Health Relevance

This training program seeks to train physician-scientist and scientist post-doctoral fellows in molecular and cellular cardiology. Our graduates will be positioned to advance our understanding of cardiovascular biology and to develop novel therapeutic approaches for various cardiovascular disorders.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Huang, Li-Shin
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Icahn School of Medicine at Mount Sinai
Internal Medicine/Medicine
Schools of Medicine
New York
United States
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Fernandez, Dawn M; Clemente, Jose C; Giannarelli, Chiara (2018) Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease. Front Physiol 9:763
Oh, Jae Gyun; Watanabe, Shin; Lee, Ahyoung et al. (2018) miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy. Circ Res 123:673-685
Michelis, Katherine C; Nomura-Kitabayashi, Aya; Lecce, Laura et al. (2018) CD90 Identifies Adventitial Mesenchymal Progenitor Cells in Adult Human Medium- and Large-Sized Arteries. Stem Cell Reports 11:242-257
Stillitano, Francesca; Karakikes, Ioannis; Hajjar, Roger J (2017) Gene Transfer in Cardiomyocytes Derived from ES and iPS Cells. Methods Mol Biol 1521:183-193
Watanabe, Shin; Leonardson, Lauren; Hajjar, Roger J et al. (2017) Cardiac Gene Delivery in Large Animal Models: Antegrade Techniques. Methods Mol Biol 1521:227-235
Turnbull, Irene C; Eltoukhy, Ahmed A; Anderson, Daniel G et al. (2017) Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents. Methods Mol Biol 1521:153-166
Abgral, Ronan; Dweck, Marc R; Trivieri, Maria Giovanna et al. (2017) Clinical Utility of Combined FDG-PET/MR to Assess Myocardial Disease. JACC Cardiovasc Imaging 10:594-597
Yoo, Jimeen; Hajjar, Roger J; Jeong, Dongtak (2017) Generation of Efficient miRNA Inhibitors Using Tough Decoy Constructs. Methods Mol Biol 1521:41-53
Aguero, Jaume; Hadri, Lahouaria; Hammoudi, Nadjib et al. (2017) Inhaled Gene Transfer for Pulmonary Circulation. Methods Mol Biol 1521:339-349
Hajjar, Roger J; Ishikawa, Kiyotake (2017) Introducing Genes to the Heart: All About Delivery. Circ Res 120:33-35

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