Over the last twenty years, training in Physiology departments throughout the country has undergone a transformation that precludes students from a thorough understanding that spans the breadth of the discipline from the whole animal to the cellular and molecular level. An exception is the Physiology Department of the Medical College of Wisconsin (MCW), that offers research training emphasizing integration of knowledge at all of these levels with development of an appreciation for the relationship of this knowledge to disease processes. With the current proposal, we will continue providing this exceptional training in cellular, molecular, and whole animal Physiology for six NIH-supported trainees each year. A unique aspect of the proposed training is the mentoring program, which includes basic scientists from a variety of traditional areas as well as clinician scientists. Graduate students wll be recruited nationally and will be selected on the basis of undergraduate academic credentials, previous research experience, and commitment to a career in research. Students must complete the first year of graduate school before they will be considered for NIH training support. Selection of trainees will be based primarily on performance in course work and in the research laboratory during the first year of graduate school. Trainees are full-time Ph.D. candidates in the MCW Graduate School of Biomedical Sciences. Trainees will complete required and elective courses and a research project that includes use of the techniques of molecular biology, isolated tissues, and whole animal or clinical investigation. The major objective is to provide trainees with a broad foundation in interdisciplinary basic science and translational research. The trainee will develop the critical thinking, integrative reasoning, and technical skills required to create and participate in evolving research careers related to prevention and control of hypertension, stroke, and respiratory diseases. An innovative feature of the training is the emphasis on addressing the national need to train for the integrated-systems future of biomedical research in the post- genome era. Research training is under the direct supervision of Physiology faculty along with co-mentors from other basic science and clinical departments. Trainees and their mentors will undergo continuous evaluation of progress through a series of formal and informal meetings with the program director and the graduate committee.
Since cardiovascular and respiratory diseases including heart attack, high blood pressure, stroke, asthma, and emphysema are major health problems in the USA and world-wide, it is necessary to train physicians and scientists to improve the care of those afflicted and to learn how to prevent these diseases. Accordingly, we are requesting funds to support six pre-doctoral students each year for the next five years in training that includes course work and research that will provide the students with an understanding of the fundamental parts of the human body (molecules and cells) and how these parts function together in the intact human body. Our students will be prepared to: a) conduct research using novel techniques and methods, and b) teach future generations of physicians and scientists how the human body works.
|Wade, Brittany; Abais-Battad, Justine M; Mattson, David L (2016) Role of immune cells in salt-sensitive hypertension and renal injury. Curr Opin Nephrol Hypertens 25:22-7|
|De Miguel, Carmen; Rudemiller, Nathan P; Abais, Justine M et al. (2015) Inflammation and hypertension: new understandings and potential therapeutic targets. Curr Hypertens Rep 17:507|
|Rudemiller, Nathan P; Mattson, David L (2015) Candidate genes for hypertension: insights from the Dahl S rat. Am J Physiol Renal Physiol 309:F993-5|
|Abais-Battad, Justine M; Rudemiller, Nathan P; Mattson, David L (2015) Hypertension and immunity: mechanisms of T cell activation and pathways of hypertension. Curr Opin Nephrol Hypertens 24:470-4|
|Muere, Clarissa; Neumueller, Suzanne; Olesiak, Samantha et al. (2015) Combined unilateral blockade of cholinergic, peptidergic, and serotonergic receptors in the ventral respiratory column does not affect breathing in awake or sleeping goats. J Appl Physiol (1985) 119:308-20|
|Weber, Tobias; Mavratzas, Athanasios; Kiesgen, Stefan et al. (2015) A Humanized Anti-CD22-Onconase Antibody-Drug Conjugate Mediates Highly Potent Destruction of Targeted Tumor Cells. J Immunol Res 2015:561814|
|Muere, Clarissa; Neumueller, Suzanne; Miller, Justin et al. (2015) Evidence for respiratory neuromodulator interdependence after cholinergic disruption in the ventral respiratory column. Respir Physiol Neurobiol 205:7-15|
|Rudemiller, Nathan P; Lund, Hayley; Priestley, Jessica R C et al. (2015) Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. Hypertension 65:1111-7|
|Muere, Clarissa; Neumueller, Suzanne; Olesiak, Samantha et al. (2015) Blockade of neurokinin-1 receptors in the ventral respiratory column does not affect breathing but alters neurochemical release. J Appl Physiol (1985) 118:732-41|
|Puissant, Madeleine M; Echert, Ashley E; Yang, Chun et al. (2015) RNASeq-derived transcriptome comparisons reveal neuromodulatory deficiency in the CO2 insensitive brown Norway rat. J Physiol 593:415-30|
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