This application is a competitive renewal for a multidisciplinary training program in cardiovascular disease. Its goal is to provide training in boh basic and clinical sciences relevant to the study of cardiovascular disease. This program proposes to support eight MD or PhD postdoctoral fellows per year. The training program will consist of a two-to-three year experience in the laboratory under the close supervision of a faculty mentor. These experiences will include molecular and cellular biology, biochemistry, physiology, epidemiology, or healthcare outcomes related to cardiovascular disease. The program utilizes faculty mentors from the Departments of Internal Medicine, (Divisions of Cardiovascular Disease, Pulmonary and Critical Care Medicine, Nephrology, Endocrinology, Metabolism and Diabetes, General Medicine, and Molecular Medicine) Pathology, Pharmacology, Integrative Physiology, Biological Chemistry, Kinesiology, Neurology, Pediatric Pulmonary Medicine and Vascular Surgery. All mentors have extensive research experience in a particular discipline and most have been involved in the training of postdoctoral fellows who have subsequently gone on to independent, productive careers in research and/or teaching. New faculty members have been incorporated into the program to extend the outstanding training opportunities in biological sciences and disciplines relevant to clinical research. The state of the art $250,000,000 comprehensive cardiovascular center completed in 2007 was accompanied by growth of the cardiovascular related faculty and available resources. A cardiovascular research facilities recently established at the North Campus Research Complex, including approximately 40,000 square feet of laboratory space, will allow further centralization and expansion of scientists involved in cardiovascular research. This training program will continue to provide a structured curriculum that contains appropriate course work, exposure to lecture series, and in-depth laboratory and/or clinical research experience. A broad range of research topics are available to trainees, including pathophysiology of atherosclerosis, thrombosis, protease biology, mechanisms of fibrosis, obesity and metabolism, mechanisms of myocardial cellular function, molecular genetics, outcomes in cardiovascular disease, quality improvement, physician decision making, and economic assessment of cardiovascular interventions. Continuation of this training grant in cardiovascular disease at the University of Michigan will capitalize on the existing and growing resources that have been assembled at this institution. The program is designed to produce the next generation of highly trained investigators devoted to understanding the pathogenesis and treatment of cardiovascular disease.

Public Health Relevance

Cardiovascular disease remains the leading cause of mortality in the United States. However, age-adjusted mortality rates due to cardiovascular events have been progressively declining due to scientific breakthroughs in prevention and treatment strategies. For this progress to continue, it is critical that we aggressively recruit and train the next generation of cardiovascular investigators. This proposal represents a diverse training program across a broad spectrum of cardiovascular diseases.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Internal Medicine/Medicine
Schools of Medicine
Ann Arbor
United States
Zip Code
Weiss, Annita Ngatchou; Anantharam, Arun; Bittner, Mary A et al. (2014) Lumenal protein within secretory granules affects fusion pore expansion. Biophys J 107:26-33
Weiss, Annita Ngatchou; Bittner, Mary A; Holz, Ronald W et al. (2014) Protein mobility within secretory granules. Biophys J 107:16-25
Schwartz, Kelly; Sekedat, Matthew D; Syed, Adnan K et al. (2014) The AgrD N-terminal leader peptide of Staphylococcus aureus has cytolytic and amyloidogenic properties. Infect Immun 82:3837-44
Kanthi, Yogendra M; Sutton, Nadia R; Pinsky, David J (2014) CD39: Interface between vascular thrombosis and inflammation. Curr Atheroscler Rep 16:425
Schumacher-Bass, Sarah M; Vesely, Eileen D; Zhang, Lian et al. (2014) Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes. Circ Res 114:982-92
Rajala, Michael W; Patterson, Christa M; Opp, Judith S et al. (2014) Leptin acts independently of food intake to modulate gut microbial composition in male mice. Endocrinology 155:748-57
Baek, Amy E; Kanthi, Yogendra; Sutton, Nadia R et al. (2013) Regulation of ecto-apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3). FASEB J 27:4419-28
Brackenbury, William J; Yuan, Yukun; O'Malley, Heather A et al. (2013) Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability. Proc Natl Acad Sci U S A 110:1089-94
Auerbach, David S; Jones, Julie; Clawson, Brittany C et al. (2013) Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome. PLoS One 8:e77843
Leshan, Rebecca L; Greenwald-Yarnell, Megan; Patterson, Christa M et al. (2012) Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat Med 18:820-3

Showing the most recent 10 out of 55 publications