The main thrust of this program is to provide research training for a minimum of 2 1/2 years in pulmonary biology for M.D. and Ph.D. candidates at the postdoctoral level as they prepare to pursue academic research careers in biomedical sciences. The research trainees for the most part will come from the 9 clinical fellows selected each year for the Harvard Pulmonary and Critical Care Program. Each potential trainee, with guidance from the program directors, will spend up to 4 months visiting investigators and laboratories to choose a well-defined topic of investigation. The trainee will then work with a senior research mentor to develop a research project including a testable mechanistic hypothesis, which will be presented to the training grant directors for review and approval. Once the project is approved the trainee will work with that mentor for the duration of training. An outstanding faculty of 19 (both MD's and PhD's) is drawn from basic science and clinical departments. The primary focus of the training is in the Pulmonary and Critical Care Unit of the Department of Medicine at Massachusetts General Hospital, but can occur anywhere in the Harvard system such as at the Broad Institute shared with MIT. Four specialized research groups, cellular and molecular biology of lung injury, occupational medicine and molecular biology, lung inflammation, and positron emission tomography, provide each trainee a more cloistered and focused environment depending on their selected research project. The senior mentor will closely monitor the trainee's progress, with periodic review by program directors. An outside scientific advisory committee will review the entire program annually including movement of the trainee to become independent of their mentor. A course in Responsible Conduct of Scientific Investigation is required of all trainees. Specific courses in Biology of the Respiratory Tract, Epidemiology and Biostatistics, Ethics and Clinical Effectiveness will be offered as part of the training. An interactive, multi-disciplinary internationally recognized faculty provides a strong and exciting intellectual environment for research. At the conclusion of the training period, each trainee will have become adept and have appropriate expertise in one of the fields identified above, such as lung cancer or asthma, to be able to compete for further training or research support in an academic environment in biomedical research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007874-15
Application #
8100184
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Colombini-Hatch, Sandra
Project Start
1997-07-01
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
15
Fiscal Year
2011
Total Cost
$372,839
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Kelly, Vanessa J; Hibbert, Kathryn A; Kohli, Puja et al. (2017) Hypoxic Pulmonary Vasoconstriction Does Not Explain All Regional Perfusion Redistribution in Asthma. Am J Respir Crit Care Med 196:834-844
Causton, Benjamin; Ramadas, Ravisankar A; Cho, Josalyn L et al. (2015) CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. J Immunol 195:683-94
Roche, Marly I; Ramadas, Ravisankar A; Medoff, Benjamin D (2013) The role of CARMA1 in T cells. Crit Rev Immunol 33:219-43
Cho, Josalyn L; Roche, Marly I; Sandall, Barry et al. (2012) Enhanced Tim3 activity improves survival after influenza infection. J Immunol 189:2879-89
Rivara, Matthew B; Bajwa, Ednan K; Januzzi, James L et al. (2012) Prognostic significance of elevated cardiac troponin-T levels in acute respiratory distress syndrome patients. PLoS One 7:e40515
Ahasic, Amy M; Zhai, Rihong; Su, Li et al. (2012) IGF1 and IGFBP3 in acute respiratory distress syndrome. Eur J Endocrinol 166:121-9
Frank, Angela J; Sheu, Chau-Chyun; Zhao, Yang et al. (2012) BCL2 genetic variants are associated with acute kidney injury in septic shock*. Crit Care Med 40:2116-23
Ramadas, Ravisankar A; Ewart, Susan L; Iwakura, Yoichiro et al. (2012) IL-36? exerts pro-inflammatory effects in the lungs of mice. PLoS One 7:e45784
Kim, Jun Ki; Vinarsky, Vladimir; Wain, John et al. (2012) In vivo imaging of tracheal epithelial cells in mice during airway regeneration. Am J Respir Cell Mol Biol 47:864-8
Kuhn, Duncan M; Vyas, Valmik K (2012) The Candida glabrata adhesin Epa1p causes adhesion, phagocytosis, and cytokine secretion by innate immune cells. FEMS Yeast Res 12:398-414

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