The Center for Clinical Epidemiology and Biostatistics (CCEB), the Cardiovascular Institute (CVI), the Division of Cardiovascular Medicine DCM), and the Pulmonary, Allergy, and Critical Care Division (PACCD) of the University of Pennsylvania School of Medicine submit this request for the renewal of an innovative and successful research training program for post-doctoral training for clinicians in cardiovascular and pulmonary clinical research, specifically designed to strengthen the links among traditional epidemiology and clinical cardiovascular and pulmonary medicine. The objective of the program is to train physicians to be rigorous and independent academic investigators able to use the range of approaches available in epidemiology to address clinical research issues regarding the etiology, prognosis, prevention and early detection, treatment, clinical economics, technology assessment, medical decision making, and quality of patient care of cardiovascular or pulmonary disease. The two- to three-year training program consists of required courses in clinical epidemiology, research methodology, and biostatistics;a required course in cardiopulmonary epidemiology;elective courses;extensive independent readings;attendance at and participation in research seminars at the CCEB, CVI, DCM, and PACCD;plus the completion of an independent research project. Specifically, the program is designed to: (1) provide in-depth knowledge of the research techniques appropriate to clinical research;(2) provide research experience with mentors in clinical epidemiology and cardiovascular and pulmonary research;and (3) bring together faculty and fellows in the CCEB, CVI, DCM, and PACCD. Trainees matriculate in the Master of Science in Clinical Epidemiology (MSCE) degree program. Strengths of the ongoing program, Cardiology and Pulmonary Research Training, are the long history of successful research training programs in the CCEB, DCM, and PACCD;the newly created CVI;the collaborative links that have been forged among these programs;the comprehensive course offerings and research programs that are available to trainees;and an extensive set of experienced program directors and faculty preceptors with successful training records. In addition, the availability of the broad range of rich expertise of the faculties in the-CCEB, DCM, CVI, and PACCD;numerous existing large databases available to these groups that can be used for research projects and training;a broad array of specialized analytic capabilities available for clinical studies (e.g., clinical trials, case-control, cohort research, etc.);and the faculties'commitment to collaborative research and training, combine to provide an ideal environment for this training program.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Einhorn, Paula
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Biostatistics & Other Math Sci
Schools of Medicine
United States
Zip Code
Bakhru, Rita N; McWilliams, David J; Wiebe, Douglas J et al. (2016) Intensive Care Unit Structure Variation and Implications for Early Mobilization Practices. An International Survey. Ann Am Thorac Soc 13:1527-37
Palakshappa, Jessica A; Anderson, Brian J; Reilly, John P et al. (2016) Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis. Crit Care 20:71
Narayan, Hari K; French, Benjamin; Khan, Abigail M et al. (2016) Noninvasive Measures of Ventricular-Arterial Coupling and Circumferential Strain Predict Cancer Therapeutics-Related Cardiac Dysfunction. JACC Cardiovasc Imaging 9:1131-1141
Reilly, John P; Anderson, Brian J; Mangalmurti, Nilam S et al. (2015) The ABO Histo-Blood Group and AKI in Critically Ill Patients with Trauma or Sepsis. Clin J Am Soc Nephrol 10:1911-20
Porteous, Mary K; Diamond, Joshua M; Christie, Jason D (2015) Primary graft dysfunction: lessons learned about the first 72 h after lung transplantation. Curr Opin Organ Transplant 20:506-14
Bakhru, Rita N; Wiebe, Douglas J; McWilliams, David J et al. (2015) An Environmental Scan for Early Mobilization Practices in U.S. ICUs. Crit Care Med 43:2360-9
Brisco, Meredith A; Kimmel, Stephen E; Coca, Steven G et al. (2014) Prevalence and prognostic importance of changes in renal function after mechanical circulatory support. Circ Heart Fail 7:68-75
Singer, Jonathan P; Peterson, Eric R; Snyder, Mark E et al. (2014) Body composition and mortality after adult lung transplantation in the United States. Am J Respir Crit Care Med 190:1012-21
Basuray, Anupam; French, Benjamin; Ky, Bonnie et al. (2014) Heart failure with recovered ejection fraction: clinical description, biomarkers, and outcomes. Circulation 129:2380-7
Reilly, John P; Bellamy, Scarlett; Shashaty, Michael G S et al. (2014) Heterogeneous phenotypes of acute respiratory distress syndrome after major trauma. Ann Am Thorac Soc 11:728-36

Showing the most recent 10 out of 55 publications