The Center for Clinical Epidemiology and Biostatistics (CCEB), together with the Cardiovascular Medicine Division and Pulmonary, Allergy, and Critical Care Division, both of the Department of Medicine, and the Division of Cardiology and Division of Pulmonary Medicine, both within the Department of Pediatrics, all of the Perelman School of Medicine at the University of Pennsylvania (Penn), propose to continue and enhance an innovative, rigorous, and successful two- to three-year research training program for clinicians in both adult and pediatric cardiology and pulmonary clinical research. The training program consists of required courses in epidemiology, clinical research methodology, biostatistics, and cardiopulmonary epidemiology;elective courses relevant to the trainees'methodologic interests;journal clubs and clinical research conferences conducted by participating faculty in the CCEB and adult and pediatric cardiology and pulmonary divisions;extensive independent readings;instruction in the responsible conduct of research;a professional development series;an apprenticeship experience with an experienced investigator;and the completion of an independent research project in cardiology or pulmonary clinical research. The program will: 1) train clinicians to be rigorous and independent academic investigators able to use the range of approaches available in epidemiology to address research issues in cardiovascular and pulmonary diseases related to the etiology, prognosis, prevention and early detection, treatment, clinical economics, technology assessment, medical decision making, and quality of patient care;2) provide closely mentored research experiences with faculty preceptors in clinical epidemiology and cardiovascular and pulmonary medicine;and 3) strengthen the links between traditional epidemiology and cardiovascular and pulmonary medicine. Trainees matriculate in the Master of Science in Clinical Epidemiology (MSCE) program. Strengths of the proposed program are: 1) the long history of successful research and training programs in the CCEB and adult and pediatric cardiology and pulmonary divisions, including this training program;2) the collaborative links that have been forged among faculty with interests in clinical research in cardiovascular and pulmonary diseases;3) the comprehensive course offerings and research programs that are available to trainees;and 4) an extensive set of experienced and multidisciplinary faculty with successful training records. In addition, numerous existing large databases that can be used for research projects and training, a broad array of specialized analytic capabilities available for clinical studies employing methods of clinical epidemiology (e.g., clinical trials, case-control, cohort research, etc.), and commitmet of faculty to collaborative research and training, combine to provide an ideal environment for this training program. Finally, Penn and the Perelman School of Medicine promote an academic environment in which basic and clinical research are encouraged and viewed as attractive career paths for physicians.

Public Health Relevance

There is a major national shortage of qualified clinician-scientists able to conduct the rigorous clinical research needed to address cardiovascular and pulmonary diseases. This training program addresses this shortage through the efforts of a distinguished, experienced, and committed training program faculty. Training will continue to be provided to those who desire careers as clinician-scientists focusing on cardiology and pulmonary clinical research through a program that provides trainees with the skills needed to design and conduct epidemiologic studies that will address the most vexing population-based questions in cardiovascular and pulmonary medicine.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Einhorn, Paula
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University of Pennsylvania
Biostatistics & Other Math Sci
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United States
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Brisco, Meredith A; Kimmel, Stephen E; Coca, Steven G et al. (2014) Prevalence and prognostic importance of changes in renal function after mechanical circulatory support. Circ Heart Fail 7:68-75
Reilly, John P; Meyer, Nuala J; Shashaty, Michael G S et al. (2014) ABO blood type A is associated with increased risk of ARDS in whites following both major trauma and severe sepsis. Chest 145:753-61
Brisco, Meredith A; Coca, Steven G; Chen, Jennifer et al. (2013) Blood urea nitrogen/creatinine ratio identifies a high-risk but potentially reversible form of renal dysfunction in patients with decompensated heart failure. Circ Heart Fail 6:233-9
Mikkelsen, Mark E; Shah, Chirag V; Meyer, Nuala J et al. (2013) The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis. Shock 40:375-81
Bakhru, Rita N; Schweickert, William D (2013) Intensive care ultrasound: I. Physics, equipment, and image quality. Ann Am Thorac Soc 10:540-8
Mikkelsen, Mark E; Christie, Jason D; Lanken, Paul N et al. (2012) The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med 185:1307-15
Lyon, Sarah M; Benson, Nicole M; Cooke, Colin R et al. (2011) The effect of insurance status on mortality and procedural use in critically ill patients. Am J Respir Crit Care Med 184:809-15
Dibble, Christopher T; Lima, Joao A C; Bluemke, David A et al. (2011) Regional left ventricular systolic function and the right ventricle: the multi-ethnic study of atherosclerosis right ventricle study. Chest 140:310-6
Hope, Aluko A; Kumanyika, Shiriki K; Shults, Justine et al. (2010) Changes in Health-Related Quality of Life among African-Americans in a lifestyle weight loss program. Qual Life Res 19:1025-33
Mikkelsen, Mark E; Gaieski, David F; Goyal, Munish et al. (2010) Factors associated with nonadherence to early goal-directed therapy in the ED. Chest 138:551-8

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