This training program provides two years of basic research training in vascular surgery for academic clinicians. It addresses the absence of adequate research training for vascular surgeons as it applies to specific areas of clinical disease. Research training in molecular and cell biology, biomechanics, coagulation thrombosis, and angiogenesis is provided with a focus on clinically relevant problems such as atherogenesis, intimal hyperplasia, prosthetic/host interactions and thrombosis. A new component is the availability of mentored advanced outcomes research training Trainees pursue a program of intense research activity supplemented with course work in research design, statistics, and evaluation of published research. The program is conducted and closely supervised by the program director, co-director and mentors who have well-established records of peer-reviewed research, and who were selected both for the current research activities and their proven commitment to train research fellows. Individual mentors are chosen from the program's faculty on the basis of the background and research interest of the individual trainee, and the trainees carry out their own projects under the close guidance of their mentor. Laboratory training can be supplemented by graduate level training at Harvard Medical School the Department of Health Care Policy and Research and Harvard's Faculty of Arts and Sciences, with course selection complementing laboratory endeavors. Upon completion of the program, trainees are capable of independent research and possess the scientific and research background needed to obtain competitive peer-reviewed grants;they have the abilities and knowledge necessary to provide translational expertise as they join medical school faculties. Selection of the trainees is based on candidates'demonstrated ability and career choice of academic practice. Applicants are resident physicians who have completed two, three or five years (i.e. is board eligible) of post-graduate surgical training. Trainees commit to two years of training;trainees desiring a shorter training period are not considered. Only those applicants with career goals in academic surgery, with a keen interest in basic resarch or outcomes research in vascular surgery, are compatible. Candidates pursuing a fellowship during a program of clinical traning must provide evidence that they will be accepted back into that program upon completion of their research training. Trainees are not involved in any clinical activities unless research related.

Public Health Relevance

Vascular Surgeons provide a practical "hands on" perspective on the relevant problems of devices and interventions on blood vessels. This program creates a cadre of surgeons with expertise in research fundamentals essential to frontline 'bench to bedside to public policy'programs in treatment of vascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007915-14
Application #
8286995
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
1999-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$429,510
Indirect Cost
$36,850
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Dews, Michael; Tan, Grace S; Hultine, Stacy et al. (2014) Masking epistasis between MYC and TGF-? pathways in antiangiogenesis-mediated colon cancer suppression. J Natl Cancer Inst 106:dju043
Busch, David R; Choe, Regine; Durduran, Turgut et al. (2014) Blood flow reduction in breast tissue due to mammographic compression. Acad Radiol 21:151-61
O'Byrne, Michael L; Glatz, Andrew C; Sunderji, Sherzana et al. (2014) Prevalence of deficient retro-aortic rim and its effects on outcomes in device closure of atrial septal defects. Pediatr Cardiol 35:1181-90
Tengood, Jillian E; Alferiev, Ivan S; Zhang, Kehan et al. (2014) Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proc Natl Acad Sci U S A 111:4245-50
Slee, Joshua B; Alferiev, Ivan S; Levy, Robert J et al. (2014) The use of the ex vivo Chandler Loop Apparatus to assess the biocompatibility of modified polymeric blood conduits. J Vis Exp :
Avitabile, Catherine M; Leonard, Mary B; Zemel, Babette S et al. (2014) Lean mass deficits, vitamin D status and exercise capacity in children and young adults after Fontan palliation. Heart 100:1702-7
O'Byrne, Michael L; Gillespie, Matthew J (2014) Will catheter interventions replace surgery for valve abnormalities? Curr Opin Cardiol 29:83-90
Choe, Regine; Putt, Mary E; Carlile, Peter M et al. (2014) Optically measured microvascular blood flow contrast of malignant breast tumors. PLoS One 9:e99683
Lynch, Jennifer M; Buckley, Erin M; Schwab, Peter J et al. (2014) Time to surgery and preoperative cerebral hemodynamics predict postoperative white matter injury in neonates with hypoplastic left heart syndrome. J Thorac Cardiovasc Surg 148:2181-8
Avitabile, Catherine M; Whitehead, Kevin; Fogel, Mark et al. (2014) Tricuspid annular plane systolic excursion does not correlate with right ventricular ejection fraction in patients with hypoplastic left heart syndrome after Fontan palliation. Pediatr Cardiol 35:1253-8

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