Training in Molecular Therapeutics for Pediatric Cardiology (TMTPC): Pediatric cardiology is a relatively small specialty with fewer than 2000 board certified specialists, and nationwide, at this time there is a small core group of laboratory and clinical researchers in this field. Nevertheless, pediatric cardiology is a requisite component of every major academic medical center, because of the relative high frequency and acuity of severe congenital heart disease early in life. With advances in genetics, imaging, pharmacology and surgical outcomes, the field of pediatric cardiology is now rich with research career development opportunities for trainees. Thus, the goal of this program is to address the as yet unmet need for more committed researchers in the field of pediatric cardiovascular disease. TMTPC program direction, aims and objectives: Program leadership will continue be provided by Dr. Robert Levy, continuing as contact PI, with responsibilities focused on laboratory research trainees. Dr. Robert Shaddy will become a 2nd PI with leadership responsibilities focused on the clinical research trainees. Dr. Shaddy is the Division Chief in Cardiology at CHOP, Vice Chair of the Department of Pediatrics at Penn, Director of CHOP's Pediatric Heart Network (PHN)-NHBLI program, and an experienced clinical researcher.
The aims of the TMTPC are to: " Identify, recruit and foster research trainees, both CHOP cardiology fellows and other scientists willing to commit to training and career development in the field of pediatric cardiovascular research " Match up trainees strengths and interests with mentoring teams " Provide guidance for structured learning opportunities " Maximize the opportunities for mentored research and career mentoring The objectives of the TMTPC are to: " Train a cadre of committed researchers to advance the field of pediatric cardiovascular research. " Provide these individuals with the skill sets and foundation for career advancement " Encourage leadership and innovation TMTPC Goals-to pursue the aims and objectives through a training program consisting of: " Didactic opportunities, including core requirements and courses designed to provide research skills " Seminars, workshops and a journal club focusing on research and progress in the field " Mentoring with a team approach, mentor training and scholarship oversight " Programmatic interactions with mainstream research through the NHBLI PHN.

Public Health Relevance

Congenital heart disease remains a major problem in the United States, as one of the leading causes of morbidity and mortality in children. The proposed program will train researchers in this field, whose goal will be to improve outcomes for children with cardiovascular disease.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Scott, Jane
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital of Philadelphia
United States
Zip Code
Dews, Michael; Tan, Grace S; Hultine, Stacy et al. (2014) Masking epistasis between MYC and TGF-? pathways in antiangiogenesis-mediated colon cancer suppression. J Natl Cancer Inst 106:dju043
Busch, David R; Choe, Regine; Durduran, Turgut et al. (2014) Blood flow reduction in breast tissue due to mammographic compression. Acad Radiol 21:151-61
O'Byrne, Michael L; Glatz, Andrew C; Sunderji, Sherzana et al. (2014) Prevalence of deficient retro-aortic rim and its effects on outcomes in device closure of atrial septal defects. Pediatr Cardiol 35:1181-90
Tengood, Jillian E; Alferiev, Ivan S; Zhang, Kehan et al. (2014) Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proc Natl Acad Sci U S A 111:4245-50
Slee, Joshua B; Alferiev, Ivan S; Levy, Robert J et al. (2014) The use of the ex vivo Chandler Loop Apparatus to assess the biocompatibility of modified polymeric blood conduits. J Vis Exp :
Avitabile, Catherine M; Leonard, Mary B; Zemel, Babette S et al. (2014) Lean mass deficits, vitamin D status and exercise capacity in children and young adults after Fontan palliation. Heart 100:1702-7
O'Byrne, Michael L; Gillespie, Matthew J (2014) Will catheter interventions replace surgery for valve abnormalities? Curr Opin Cardiol 29:83-90
Choe, Regine; Putt, Mary E; Carlile, Peter M et al. (2014) Optically measured microvascular blood flow contrast of malignant breast tumors. PLoS One 9:e99683
Lynch, Jennifer M; Buckley, Erin M; Schwab, Peter J et al. (2014) Time to surgery and preoperative cerebral hemodynamics predict postoperative white matter injury in neonates with hypoplastic left heart syndrome. J Thorac Cardiovasc Surg 148:2181-8
Avitabile, Catherine M; Whitehead, Kevin; Fogel, Mark et al. (2014) Tricuspid annular plane systolic excursion does not correlate with right ventricular ejection fraction in patients with hypoplastic left heart syndrome after Fontan palliation. Pediatr Cardiol 35:1253-8

Showing the most recent 10 out of 61 publications