This application is for the revision of a competing renewal in the Cardiovascular Pathophysiology training program at UAB for 6 pre-doctoral students which is currently in its 14th year. Since the appointment of the first trainees in late 1999 36 students have entered the training program with 28 having completed their graduate studies and developed science related careers in respected national research centers and universities. Students over the last ten years have graduated within 5 years, have an average of 6 publications and the cumulative H factor for all trainee publications (120) is 41. The training will be undertaken by faculty from six separate departments at the institution (four basic science and two clinical) with a expertise in a broad range of research areas relevant to cardiovascular research. This training program recognizes the integrated and multi-disciplinary nature of modern cardiovascular research and includes faculty from six research centers at UAB encompassing institutional areas of strength in Free Radical Biology, Nephrology Research, Clinical Nutrition, Cardiovascular and Diabetes and Hypertension. The students will earn degrees in the graduate programs in pathology, physiology or cell biology. Students supported by the proposal will have completed the first year, selected a project and mentor with cardiovascular relevance and demonstrated excellence in their studies and research potential. The program plan consists of a didactic component that emphasizes cardiovascular disease in the context of other pathologies with a particular emphasis on molecular mechanisms of disease. Trainees will be able to observe key cardiovascular interventions including angioplasty and flow mediated dilatation. An area of increasing significance in cardiovascular research and a strength at UAB is the integration of bioinformatics into many aspects of research. We also include courses that encompass career enhancement components including preparation for research applications, public presentations, review of papers, and preparation of review articles. In addition we have included an emerging and important area in graduate education in the development of the management and personnel skills necessary to direct a research group. No overlap between this application with current training programs at this institution exist.

Public Health Relevance

Cardiovascular disease is a major cause of morbidity and mortality in developed countries including the United States. This proposal is designed to provide the training for the next generation of cardiovascular researchers.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL007918-16
Application #
8608354
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Wang, Wayne C
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Krzywanski, David M; Moellering, Douglas R; Westbrook, David G et al. (2016) Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry. Circ Cardiovasc Genet 9:26-36
Alexander, Grant C; Vines, Jeremy B; Hwang, Patrick et al. (2016) Novel Multifunctional Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo. ACS Appl Mater Interfaces 8:5178-87
Kesterson, Robert A; Johnson, Larry W; Lambert, Laura J et al. (2016) Generation of Mitochondrial-nuclear eXchange Mice via Pronuclear Transfer. Bio Protoc 6:
Giordano, Samantha; Hage, Fadi G; Xing, Dongqi et al. (2015) Estrogen and Cardiovascular Disease: Is Timing Everything? Am J Med Sci 350:27-35
Black, Leland L; Srivastava, Roshni; Schoeb, Trenton R et al. (2015) Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice. J Immunol 195:4685-98
Oh, Joo-Yeun; Stapley, Ryan; Harper, Victoria et al. (2015) Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements. Transfusion 55:2967-78
Wall, S B; Oh, J-Y; Mitchell, L et al. (2015) Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. Redox Biol 4:346-54
Stapley, Ryan; Rodriguez, Cilina; Oh, Joo-Yeun et al. (2015) Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage. Free Radic Biol Med 85:207-18
El-Ferzli, George T; Andukuri, Adinarayana; Alexander, Grant et al. (2015) A Nitric Oxide-Releasing Self-Assembled Peptide Amphiphile Nanomatrix for Improving the Biocompatibility of Microporous Hollow Fibers. ASAIO J 61:589-95
Kramer, Philip A; Prichard, Lynn; Chacko, Balu et al. (2015) Inhibition of the lymphocyte metabolic switch by the oxidative burst of human neutrophils. Clin Sci (Lond) 129:489-504

Showing the most recent 10 out of 77 publications