This Institutional National Research Service Award will support the continued development of successful predoctoral and postdoctoral training programs in the theory and methods relevant to the epidemiology and prevention of cardiovascular disease. The two-year postdoctoral program consists of a multidisciplinary didactic curriculum leading to one of three Masters Degrees, a series of skill-building workshops and research seminars, and a mentored research experience with a multidisciplinary mentorial committee to develop the skills and knowledge needed for a career as an independent investigator in preventive cardiology. The four-year predoctoral program leading to the PhD in Epidemiology will expand to one predoctoral trainee per year, and include didactic coursework and a mentored research experience requiring primary data collection for the PhD dissertation. The mentored research experiences for both components will be carried out in one of five multidisciplinary research clusters (Behavioral Science, Cardiovascular Clinical Trials, Epidemiology of Cardiovascular Disease, Outcomes/Cost Effectiveness Research, and Vascular Biology/Metabolic Studies). Both the didactic coursework and mentored research will integrate with newly expanded clinical and translational research programs supported by a Clinical and Translational Science Award from the NIH and with the development of a new Cardiovascular Research Institute. Trainees will be recruited from national and local pools of eligible candidates with an emphasis on recruiting members of underrepresented minority groups and researchers from the Deaf Community. A rigorous process of program evaluation will ensure continued improvement in operations and outcomes. With its Clinical and Translational Science Award, a new Cardiovascular Research Institute, a now established PhD Program in Epidemiology, and the availability of a large multidisciplinary group of seasoned and enthusiastic mentors, the University of Rochester is well-positioned to support both a continuing postdoctoral fellowship as well as an expanded predoctoral program in the epidemiology and prevention of cardiovascular disease.
Cardiovascular diseases, including coronary heart disease and stroke, are the leading causes of death, disability, and healthcare expenditure in the U.S. and the World. These diseases are largely preventable. The translation of basic science to human studies, clinical trials, and population-wide research will require the education and training of investigators in multidisciplinary preventive cardiology research.
|Burke, Ryan M; Lighthouse, Janet K; Quijada, Pearl et al. (2018) Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure. Proc Natl Acad Sci U S A 115:E3436-E3445|
|Usoh, Chinenye O; Sherazi, Saadia; Szepietowska, Barbara et al. (2018) Influence of Diabetes Mellitus on Outcomes in Patients After Left Ventricular Assist Device Implantation. Ann Thorac Surg 106:555-560|
|Field, David J; Aggrey-Amable, Angela A; Blick, Sara K et al. (2017) Platelet factor 4 increases bone marrow B cell development and differentiation. Immunol Res 65:1089-1094|
|Evans, Kristin A; Hopke, Philip K; Utell, Mark J et al. (2017) Triggering of ST-elevation myocardial infarction by ambient wood smoke and other particulate and gaseous pollutants. J Expo Sci Environ Epidemiol 27:198-206|
|McKee, Kimberly Schmitt; Seplaki, Christopher; Fisher, Susan et al. (2017) Cumulative Physiologic Dysfunction and Pregnancy: Characterization and Association with Birth Outcomes. Matern Child Health J 21:147-155|
|Zhu, Qiuyu Martin; Ko, Kyung Ae; Ture, Sara et al. (2017) Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice. Arterioscler Thromb Vasc Biol 37:264-270|
|Block, Robert C; Holub, Ashley; Abdolahi, Amir et al. (2017) Effects of aspirin in combination with EPA and DHA on HDL-C cholesterol and ApoA1 exchange in individuals with type 2 diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids 126:25-31|
|Assibey-Mensah, Vanessa; Liu, Kaibo; Thurston, Sally W et al. (2016) Impact of the 2008 Beijing Olympics on the risk of pregnancy complications. Arch Environ Occup Health 71:208-15|
|Knight, Walter E; Chen, Si; Zhang, Yishuai et al. (2016) PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction. Proc Natl Acad Sci U S A 113:E7116-E7125|
|Block, Robert C; Abdolahi, Amir; Niemiec, Christopher P et al. (2016) Effects of an evidence-based computerized virtual clinician on low-density lipoprotein and non-high-density lipoprotein cholesterol in adults without cardiovascular disease: The Interactive Cholesterol Advisory Tool. Health Informatics J 22:897-910|
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