This is the first competing renewal application for Yale University School of Medicine's Vascular Research Postdoctoral Training Grant. The goal of this program is to provide laboratory and translational research training for highly qualified physician (M.D. and M.D./Ph.D.) and Ph.D. postdoctoral fellows in vascular biology, in preparation for careers as independent investigators in blood vessel biology- and medicine-related disciplines. Selection of trainees will be based on a demonstrated commitment to vascular biology and strong prior research experience or potential of same. Applications will be encouraged from both clinical and basic science departments, with a nationwide competition for the 7 yearly slots. Minority applicants will be specifically solicited. The training will be mentor-based, also including both advisory committees and didactic courses. The minimum duration of training per fellow will be 2 years, with the majority of fellows remaining in the program for 3 years. The Cardiovascular Medicine Division of Internal Medicine and Yale's Interdisciplinary Program in Vascular Biology and Transplantation will be the central foundations for the program. In fact, a key asset to this training program is Yale's interdisciplinary strength in vascular biology. Departmental affiliations for the primary participating faculty include Internal Medicine (Cardiovascular Medicine, Pulmonary and Critical Care Medicine), Immunobiology, Pharmacology, Molecular, Cellular and Developmental Biology, Pathology, Genetics, Bioengineering, Cellular and Molecular Physiology, Epidemiology and Public Health and Cardiothoracic Surgery. This is a testimony to the wide spectrum of strong vascular biology laboratories at Yale and the institutional nature of the program. The faculty was chosen based on impressive histories of mentorship, ongoing vascular research productivity, strong extramural support and commitment to serve as mentors within the program. Examples of vascular research opportunities include: (1) molecular determinants and consequences of leukocyte-endothelial cell interactions;(2) microcirculatory analysis of neurohumoral and cell coupling mechanisms which control vasomotion;(3) molecular imaging of angiogenesis and vascular remodeling utilizing nuclear and MR imaging in animal models;(4) mapping and identification of genes that contribute to the development of vascular disease (arterio-venous malformation, coronary artery disease) in humans, through molecular genetic techniques;(5) engineering of vascular biomaterials, and molecular determinants of healing responses post-implantation;(6) effects of inflammation and reactive oxygen species generation on endothelial homeostasis;(7) regulators of endothelial dysfunction in human disease states, such as congestive heart failure;and (8) generation of angiogenic gene regulators for use in clinical trials. As described, this represents a wide range of disease-related vascular research, with key translational components. Trainee progress will be monitored by each mentor, the trainee's advisory committee and the Program Director. It is the expectation that, through this program, we will train future national and international leaders in vascular research. Cardiovascular disease is the leading cause of death in the U.S., and a major cause of morbidity and mortality world-wide. This program will provide important opportunities for individuals from multiple disciplines to eventually lead high impact efforts at reducing the incidence of, and improving outcomes in, cardiovascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007950-10
Application #
7851287
Study Section
Special Emphasis Panel (ZHL1-CSR-J (F1))
Program Officer
Commarato, Michael
Project Start
2000-09-30
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
10
Fiscal Year
2010
Total Cost
$204,395
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Ceneri, Nicolle; Zhao, Lina; Young, Bryan D et al. (2017) Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1? Production. Arterioscler Thromb Vasc Biol 37:328-340
Mazurek, R; Dave, J M; Chandran, R R et al. (2017) Vascular Cells in Blood Vessel Wall Development and Disease. Adv Pharmacol 78:323-350
Sawyer, Andrew J; Kyriakides, Themis R (2016) Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization. Adv Drug Deliv Rev 97:56-68
Baeyens, Nicolas; Larrivée, Bruno; Ola, Roxana et al. (2016) Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia. J Cell Biol 214:807-16
Ola, Roxana; Dubrac, Alexandre; Han, Jinah et al. (2016) PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. Nat Commun 7:13650
Padmanabhan, Jagannath; Augelli, Michael J; Cheung, Bettina et al. (2016) Regulation of cell-cell fusion by nanotopography. Sci Rep 6:33277
Marin, Ethan P; Jozsef, Levente; Di Lorenzo, Annarita et al. (2016) The Protein Acyl Transferase ZDHHC21 Modulates ?1 Adrenergic Receptor Function and Regulates Hemodynamics. Arterioscler Thromb Vasc Biol 36:370-9
Moore, Laura Beth; Sawyer, Andrew J; Saucier-Sawyer, Jennifer et al. (2016) Nanoparticle delivery of miR-223 to attenuate macrophage fusion. Biomaterials 89:127-35
Zaha, Vlad G; Qi, Dake; Su, Kevin N et al. (2016) AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia. J Mol Cell Cardiol 91:104-13
Dubrac, Alexandre; Genet, Gael; Ola, Roxana et al. (2016) Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization. Circulation 133:409-21

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