This proposal for a training program in the area of sleep and its disorders. There is growing evidence of the prevalence of sleep disorders in the American population, and that problems related to inadequate sleep have a major impact on many aspects of our society. At a basic level, little is known about the fundamental mechanisms that control sleep and the function(s) of sleep. Thus, there is a major opportunity for scientific discovery. One of the barriers that is recognized to advancing the knowledge base in this area is the paucity of investigators, both those engaged in basic research and in patient-oriented research. This application describes a training program that is based on the relatively unique faculty resources and structure at the University of Pennsylvania for support of research in sleep and its disorders (the Center for Sleep and Respiratory Neurobiology). The proposal describes four specific training aspects that are intended to complete the matrix for training opportunities at the University of Pennsylvania in the area of research in sleep/sleep disorders. These four aspects are the following: a) a graduate program in neurobiology of sleep and circadian rhythm. This will be based on the highly successful and well developed Neuroscience Graduate Program. We will utilize, where appropriate, structures, courses and other resources developed by this group;b) a new graduate track in genomics/computational biology;c) a targeted MD/PhD program to train physician-scientists in sleep research. This aspect of our program will be based on the outstanding institutional MD/PhD program at the University of Pennsylvania;and d) a postdoctoral training program for nurse investigators. This will be based on the preeminent School of Nursing at the University of Pennsylvania. There are members of the tenured 'faculty at the School who are funded investigators in outcomes of sleep disorders. This, together with the other rich intellectual resources at the School of Nursing, provides a unique opportunity to develop a much needed national program to train nurse investigators in this area. All of these components of the program will utilize the extensive resources for research that have been developed by the Center for Sleep at the University of Pennsylvania.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007953-14
Application #
8489321
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Tigno, Xenia
Project Start
2000-09-01
Project End
2015-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
14
Fiscal Year
2013
Total Cost
$405,088
Indirect Cost
$21,838
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Li, Junxin; Vitiello, Michael V; Gooneratne, Nalaka S (2018) Sleep in Normal Aging. Sleep Med Clin 13:1-11
Schroeder, Krista; Malone, Susan Kohl; McCabe, Ellen et al. (2018) Addressing the Social Determinants of Health: A Call to Action for School Nurses. J Sch Nurs 34:182-191
Mindell, Jodi A; Williamson, Ariel A (2018) Benefits of a bedtime routine in young children: Sleep, development, and beyond. Sleep Med Rev 40:93-108
Izci-Balserak, Bilgay; Keenan, Brendan T; Corbitt, Charles et al. (2018) Changes in Sleep Characteristics and Breathing Parameters During Sleep in Early and Late Pregnancy. J Clin Sleep Med 14:1161-1168
Ly, Sarah; Pack, Allan I; Naidoo, Nirinjini (2018) The neurobiological basis of sleep: Insights from Drosophila. Neurosci Biobehav Rev 87:67-86
Matura, Lea Ann; Malone, Susan; Jaime-Lara, Rosario et al. (2018) A Systematic Review of Biological Mechanisms of Fatigue in Chronic Illness. Biol Res Nurs 20:410-421
Koberstein, John N; Poplawski, Shane G; Wimmer, Mathieu E et al. (2018) Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism. Sci Signal 11:
Li, Junxin; Yang, Binbin; Varrasse, Miranda et al. (2018) Sleep Among Long-Term Care Residents in China: A Narrative Review of Literature. Clin Nurs Res 27:35-60
Patterson, Freda; Malone, Susan Kohl; Grandner, Michael A et al. (2018) Interactive effects of sleep duration and morning/evening preference on cardiovascular risk factors. Eur J Public Health 28:155-161
Li, Junxin; Cacchione, Pamela Z; Hodgson, Nancy et al. (2017) Afternoon Napping and Cognition in Chinese Older Adults: Findings from the China Health and Retirement Longitudinal Study Baseline Assessment. J Am Geriatr Soc 65:373-380

Showing the most recent 10 out of 73 publications