This proposal describes an interdisciplinary training program in Cardiovascular Biomedical Engineering dedicated to training predoctoral students. Students will receive a multidisciplinary education in the biological and engineering disciplines focusing on cardiovascular health. A major goal of this program is to meet the demands of a growing biomedical engineering field and interdisciplinary workforce. This program takes advantage of the strong expertise in bioengineering and cardiovascular biology present at the University of Arizona. Areas of expertise include: biomechanics, biomaterials, optics, molecular genetics, vascular physiology, radiology, imaging, tissue engineering, genetic engineering, and biocomputing. Training faculty are independent researchers with a shared commitment to graduate training. The faculty have a strong record of support and are actively involved in collaborative research activities. Clinical and industrial experiences will foster the development of translational research projects for trainees. Training within this program involves laboratory and didactic experience. The didactic component includes the core biomedical engineering graduate curriculum, the availability of numerous elective graduate courses and regularly scheduled forums and seminars. Students participate in informal discussion groups and have multiple opportunities to present their research in oral and poster form. Progress of the trainees is monitored by the trainee's mentor, their respective graduate program, a training grant program committee, and an advisory board. Students perform research rotations and projects in participating laboratories that are focused on: microvascular engineering, vascular biomechanics, vascular modeling, optical vascular imaging, ultrasound and magnetic resonance imaging of vascular perfusion, cardiovascular instrumentation, cardiovascular devices, cardiac electrophysiology, vascular genomics and molecular diagnostics of vascular tissues. This is a resubmission of a renewal application;graduates of this training program from the last 10 years are now engaged in post-doctoral training and have taken positions of leadership in the biomedical industry.

Public Health Relevance

Cardiovascular biomedical engineers create the medical technology used in the diagnosis and treatment of cardiovascular disease. Continued advancement in this complex field requires students with unique didactic and laboratory training. In the Cardiovascular Biomedical Engineering Training Program, students receive the basic and advanced coursework, laboratory training, and skill development necessary to develop cutting-edge diagnostic equipment, pharmacological agents, and medical devices directed at the cardiovascular system.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Carlson, Drew E
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University of Arizona
Biomedical Engineering
Schools of Engineering
United States
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Rosado-Toro, Jose A; Altbach, Maria I; Rodriguez, Jeffrey J (2016) Dynamic Programming Using Polar Variance for Image Segmentation. IEEE Trans Image Process :
Haskett, Darren G; Maestas, David; Howerton, Stephen J et al. (2016) 2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm. Microsc Microanal 22:349-60
Chen, Liu Qi; Randtke, Edward A; Jones, Kyle M et al. (2015) Evaluations of Tumor Acidosis Within In Vivo Tumor Models Using Parametric Maps Generated with Acido CEST MRI. Mol Imaging Biol 17:488-96
Angus, Scott V; Cho, Soohee; Harshman, Dustin K et al. (2015) A portable, shock-proof, surface-heated droplet PCR system for Escherichia coli detection. Biosens Bioelectron 74:360-8
Jones, Kyle M; Randtke, Edward A; Howison, Christine M et al. (2015) Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI. Mol Imaging Biol 17:177-84
Carbary-Ganz, Jordan L; Welge, Weston A; Barton, Jennifer K et al. (2015) In vivo molecular imaging of colorectal cancer using quantum dots targeted to vascular endothelial growth factor receptor 2 and optical coherence tomography/laser-induced fluorescence dual-modality imaging. J Biomed Opt 20:096015
Harshman, Dustin K; Rao, Brianna M; McLain, Jean E et al. (2015) Innovative qPCR using interfacial effects to enable low threshold cycle detection and inhibition relief. Sci Adv 1:e1400061
Ardila, Diana C; Tamimi, Ehab; Danford, Forest L et al. (2015) TGFβ2 differentially modulates smooth muscle cell proliferation and migration in electrospun gelatin-fibrinogen constructs. Biomaterials 37:164-73
Martirosyan, Nikolay L; Skoch, Jesse; Watson, Jeffrey R et al. (2015) Integration of indocyanine green videoangiography with operative microscope: augmented reality for interactive assessment of vascular structures and blood flow. Neurosurgery 11 Suppl 2:252-7; discussion 257-8
Rosado-Toro, José A; Barr, Tomoe; Galons, Jean-Philippe et al. (2015) Automated breast segmentation of fat and water MR images using dynamic programming. Acad Radiol 22:139-48

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