This proposal describes an interdisciplinary training program in Cardiovascular Biomedical Engineering dedicated to training predoctoral students. Students will receive a multidisciplinary education in the biological and engineering disciplines focusing on cardiovascular health. A major goal of this program is to meet the demands of a growing biomedical engineering field and interdisciplinary workforce. This program takes advantage of the strong expertise in bioengineering and cardiovascular biology present at the University of Arizona. Areas of expertise include: biomechanics, biomaterials, optics, molecular genetics, vascular physiology, radiology, imaging, tissue engineering, genetic engineering, and biocomputing. Training faculty are independent researchers with a shared commitment to graduate training. The faculty have a strong record of support and are actively involved in collaborative research activities. Clinical and industrial experiences will foster the development of translational research projects for trainees. Training within this program involves laboratory and didactic experience. The didactic component includes the core biomedical engineering graduate curriculum, the availability of numerous elective graduate courses and regularly scheduled forums and seminars. Students participate in informal discussion groups and have multiple opportunities to present their research in oral and poster form. Progress of the trainees is monitored by the trainee's mentor, their respective graduate program, a training grant program committee, and an advisory board. Students perform research rotations and projects in participating laboratories that are focused on: microvascular engineering, vascular biomechanics, vascular modeling, optical vascular imaging, ultrasound and magnetic resonance imaging of vascular perfusion, cardiovascular instrumentation, cardiovascular devices, cardiac electrophysiology, vascular genomics and molecular diagnostics of vascular tissues. This is a resubmission of a renewal application;graduates of this training program from the last 10 years are now engaged in post-doctoral training and have taken positions of leadership in the biomedical industry.

Public Health Relevance

Cardiovascular biomedical engineers create the medical technology used in the diagnosis and treatment of cardiovascular disease. Continued advancement in this complex field requires students with unique didactic and laboratory training. In the Cardiovascular Biomedical Engineering Training Program, students receive the basic and advanced coursework, laboratory training, and skill development necessary to develop cutting-edge diagnostic equipment, pharmacological agents, and medical devices directed at the cardiovascular system.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007955-13
Application #
8494665
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
2000-04-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
13
Fiscal Year
2013
Total Cost
$302,474
Indirect Cost
$17,684
Name
University of Arizona
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Garlant, Jacob A; Ammann, Kaitlyn R; Slepian, Marvin J (2018) Stretchable Electronic Wearable Motion Sensors Delineate Signatures of Human Motion Tasks. ASAIO J 64:351-359
Lindeman, Leila R; Randtke, Edward A; High, Rachel A et al. (2018) A comparison of exogenous and endogenous CEST MRI methods for evaluating in vivo pH. Magn Reson Med 79:2766-2772
Jones, Kyle M; Pollard, Alyssa C; Pagel, Mark D (2018) Clinical applications of chemical exchange saturation transfer (CEST) MRI. J Magn Reson Imaging 47:11-27
Jones, Kyle M; Pagel, Mark D; Cárdenas-Rodríguez, Julio (2018) Linearization improves the repeatability of quantitative dynamic contrast-enhanced MRI. Magn Reson Imaging 47:16-24
Ulep, Tiffany-Heather; Yoon, Jeong-Yeol (2018) Challenges in paper-based fluorogenic optical sensing with smartphones. Nano Converg 5:14
Jones, Kyle M; Stuehm, Carol A; Hsu, Charles C et al. (2017) Imaging Lung Cancer by Using Chemical Exchange Saturation Transfer MRI With Retrospective Respiration Gating. Tomography 3:201-210
Sinharay, Sanhita; Randtke, Edward A; Jones, Kyle M et al. (2017) Noninvasive detection of enzyme activity in tumor models of human ovarian cancer using catalyCEST MRI. Magn Reson Med 77:2005-2014
McConnell, Mark; Tal Grinspan, Lauren; Williams, Michael R et al. (2017) Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap. Biochemistry 56:3403-3413
Daryaei, Iman; Jones, Kyle M; Pagel, Mark D (2017) Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent. Chemistry 23:6514-6517
Sweeney, Robin E; Yoon, Jeong-Yeol (2017) Angular photodiode array-based device to detect bacterial pathogens in a wound model. IEEE Sens J 17:6911-6917

Showing the most recent 10 out of 73 publications