This proposal describes an interdisciplinary training program in Cardiovascular Biomedical Engineering dedicated to training predoctoral students. Students will receive a multidisciplinary education in the biological and engineering disciplines focusing on cardiovascular health. A major goal of this program is to meet the demands of a growing biomedical engineering field and interdisciplinary workforce. This program takes advantage of the strong expertise in bioengineering and cardiovascular biology present at the University of Arizona. Areas of expertise include: biomechanics, biomaterials, optics, molecular genetics, vascular physiology, radiology, imaging, tissue engineering, genetic engineering, and biocomputing. Training faculty are independent researchers with a shared commitment to graduate training. The faculty have a strong record of support and are actively involved in collaborative research activities. Clinical and industrial experiences will foster the development of translational research projects for trainees. Training within this program involves laboratory and didactic experience. The didactic component includes the core biomedical engineering graduate curriculum, the availability of numerous elective graduate courses and regularly scheduled forums and seminars. Students participate in informal discussion groups and have multiple opportunities to present their research in oral and poster form. Progress of the trainees is monitored by the trainee's mentor, their respective graduate program, a training grant program committee, and an advisory board. Students perform research rotations and projects in participating laboratories that are focused on: microvascular engineering, vascular biomechanics, vascular modeling, optical vascular imaging, ultrasound and magnetic resonance imaging of vascular perfusion, cardiovascular instrumentation, cardiovascular devices, cardiac electrophysiology, vascular genomics and molecular diagnostics of vascular tissues. This is a resubmission of a renewal application;graduates of this training program from the last 10 years are now engaged in post-doctoral training and have taken positions of leadership in the biomedical industry.

Public Health Relevance

Cardiovascular biomedical engineers create the medical technology used in the diagnosis and treatment of cardiovascular disease. Continued advancement in this complex field requires students with unique didactic and laboratory training. In the Cardiovascular Biomedical Engineering Training Program, students receive the basic and advanced coursework, laboratory training, and skill development necessary to develop cutting-edge diagnostic equipment, pharmacological agents, and medical devices directed at the cardiovascular system.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL007955-14
Application #
8680297
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Arizona
Department
Biomedical Engineering
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Carbary-Ganz, Jordan L; Barton, Jennifer K; Utzinger, Urs (2014) Quantum dots targeted to vascular endothelial growth factor receptor 2 as a contrast agent for the detection of colorectal cancer. J Biomed Opt 19:086003
Orsinger, Gabriel V; Watson, Jennifer M; Gordon, Michael et al. (2014) Simultaneous multiplane imaging of human ovarian cancer by volume holographic imaging. J Biomed Opt 19:36020
Harshman, Dustin K; Reyes, Roberto; Park, Tu San et al. (2014) Enhanced nucleic acid amplification with blood in situ by wire-guided droplet manipulation (WDM). Biosens Bioelectron 53:167-74
Keyes, Joseph T; Lockwood, Danielle R; Utzinger, Urs et al. (2013) Comparisons of planar and tubular biaxial tensile testing protocols of the same porcine coronary arteries. Ann Biomed Eng 41:1579-91
Tran, Phat L; Gamboa, Jessica R; McCracken, Katherine E et al. (2013) Nanowell-trapped charged ligand-bearing nanoparticle surfaces: a novel method of enhancing flow-resistant cell adhesion. Adv Healthc Mater 2:1019-27
Keyes, Joseph T; Lockwood, Danielle R; Simon, Bruce R et al. (2013) Deformationally dependent fluid transport properties of porcine coronary arteries based on location in the coronary vasculature. J Mech Behav Biomed Mater 17:296-306
Gamboa, Jessica R; Mohandes, Samir; Tran, Phat L et al. (2013) Linear fibroblast alignment on sinusoidal wave micropatterns. Colloids Surf B Biointerfaces 104:318-25
Nedrud, Joshua; Labeit, Siegfried; Gotthardt, Michael et al. (2011) Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle. Biophys J 101:1385-92
Ashton, J H; Mertz, J A M; Harper, J L et al. (2011) Polymeric endoaortic paving: Mechanical, thermoforming, and degradation properties of polycaprolactone/polyurethane blends for cardiovascular applications. Acta Biomater 7:287-94
King, Nicholas M P; Methawasin, Methajit; Nedrud, Joshua et al. (2011) Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells. J Gen Physiol 137:81-91

Showing the most recent 10 out of 15 publications