This is a renewal application for a SCHOOL-WIDE PREDOCTORAL training program, which was initiated in 2003. It is designed to train yearly six graduate students in the field of Cardiovascular Biology. Cardiovascular diseases represent the major causes of mortality and morbidity in the United States, and thus require major efforts in fundamental and translational research. The training program provides a format for the training of future scientists who will devote time and efforts in developing the tools to study and control the disease. The major goal of this application is to provide a formal research and academic training for Ph.D. as well as M.D.-Ph.D. candidates that have been carefully selected from a total pool of applicants to the medical school, thus capturing attention of competent young scientists to cardiovascular research, leading the way to a career in biomedical research. Training is offered in topics related to cardiovascular disease, including atherosclerosis, heart failure and hypertension, with application of disciplines such as physiology, pharmacology, biochemistry, molecular biology and genetics. The curriculum also includes special courses in cardiovascular biology, with equal emphasis on interdisciplinary and translational research. Trainees participate in various activities of the Whitaker Cardiovascular Institute (CVI) at our institute. The training faculty is affiliated with basic science departments, the department of Medicine and with the CVI. There are strong research interactions between members of the training program, at faculty and student levels. Each faculty has experience in teaching, all have had several trainees that have gone on to hold academic positions, and all have at least one active grant from NIH. During the funding period we were able to train graduate students with documented success in research and academic sl

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston University
Schools of Medicine
United States
Zip Code
Eisenstein, Anna; Ravid, Katya (2014) G protein-coupled receptors and adipogenesis: a focus on adenosine receptors. J Cell Physiol 229:414-21
Krasner, Nadia M; Ido, Yasuo; Ruderman, Neil B et al. (2014) Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS One 9:e97554
Johnston-Cox, Hillary; Eisenstein, Anna S; Koupenova, Milka et al. (2014) The macrophage A2B adenosine receptor regulates tissue insulin sensitivity. PLoS One 9:e98775
Mitsche, Matthew A; Packer, Laura E; Brown, Jeffrey W et al. (2014) Surface tensiometry of apolipoprotein B domains at lipid interfaces suggests a new model for the initial steps in triglyceride-rich lipoprotein assembly. J Biol Chem 289:9000-12
Thompson, Melissa D; Mei, Yu; Weisbrod, Robert M et al. (2014) Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem 289:19907-16
Parker-Duffen, Jennifer L; Walsh, Kenneth (2014) Cardiometabolic effects of adiponectin. Best Pract Res Clin Endocrinol Metab 28:81-91
Valentine, Rudy J; Coughlan, Kimberly A; Ruderman, Neil B et al. (2014) Insulin inhibits AMPK activity and phosphorylates AMPK Ser???/??¹ through Akt in hepatocytes, myotubes and incubated rat skeletal muscle. Arch Biochem Biophys 562:62-9
Parker-Duffen, Jennifer L; Nakamura, Kazuto; Silver, Marcy et al. (2014) Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo. J Biol Chem 289:16200-13
Eisenstein, Anna; Carroll, Shannon H; Johnston-Cox, Hillary et al. (2014) An adenosine receptor-Krüppel-like factor 4 protein axis inhibits adipogenesis. J Biol Chem 289:21071-81
Mitsche, Matthew A; Small, Donald M (2013) Surface pressure-dependent conformation change of apolipoprotein-derived amphipathic *-helices. J Lipid Res 54:1578-88

Showing the most recent 10 out of 35 publications