This is a renewal application for a SCHOOL-WIDE PREDOCTORAL training program, which was initiated in 2003. It is designed to train yearly six graduate students in the field of Cardiovascular Biology. Cardiovascular diseases represent the major causes of mortality and morbidity in the United States, and thus require major efforts in fundamental and translational research. The training program provides a format for the training of future scientists who will devote time and efforts in developing the tools to study and control the disease. The major goal of this application is to provide a formal research and academic training for Ph.D. as well as M.D.-Ph.D. candidates that have been carefully selected from a total pool of applicants to the medical school, thus capturing attention of competent young scientists to cardiovascular research, leading the way to a career in biomedical research. Training is offered in topics related to cardiovascular disease, including atherosclerosis, heart failure and hypertension, with application of disciplines such as physiology, pharmacology, biochemistry, molecular biology and genetics. The curriculum also includes special courses in cardiovascular biology, with equal emphasis on interdisciplinary and translational research. Trainees participate in various activities of the Whitaker Cardiovascular Institute (CVI) at our institute. The training faculty is affiliated with basic science departments, the department of Medicine and with the CVI. There are strong research interactions between members of the training program, at faculty and student levels. Each faculty has experience in teaching, all have had several trainees that have gone on to hold academic positions, and all have at least one active grant from NIH. During the funding period we were able to train graduate students with documented success in research and academic sl

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
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Boston University
Schools of Medicine
United States
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Backman, Daniel E; LeSavage, Bauer L; Shah, Shivem B et al. (2017) A Robust Method to Generate Mechanically Anisotropic Vascular Smooth Muscle Cell Sheets for Vascular Tissue Engineering. Macromol Biosci 17:
Mattson, Jeffrey M; Turcotte, Raphaƫl; Zhang, Yanhang (2017) Glycosaminoglycans contribute to extracellular matrix fiber recruitment and arterial wall mechanics. Biomech Model Mechanobiol 16:213-225
Klimtchuk, Elena S; Prokaeva, Tatiana B; Spencer, Brian H et al. (2017) In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis. Amyloid 24:115-122
Mattson, Jeffrey M; Zhang, Yanhang (2017) Structural and Functional Differences Between Porcine Aorta and Vena Cava. J Biomech Eng 139:
Backman, Daniel E; LeSavage, Bauer L; Wong, Joyce Y (2017) Versatile and inexpensive Hall-Effect force sensor for mechanical characterization of soft biological materials. J Biomech 51:118-122
Valero-Munoz, Maria; Li, Shanpeng; Wilson, Richard M et al. (2016) Dual Endothelin-A/Endothelin-B Receptor Blockade and Cardiac Remodeling in Heart Failure With Preserved Ejection Fraction. Circ Heart Fail 9:
Lucero, Hector A; Patterson, Shenia; Matsuura, Shinobu et al. (2016) Quantitative histological image analyses of reticulin fibers in a myelofibrotic mouse. J Biol Methods 3:
Coughlan, Kimberly A; Valentine, Rudy J; Sudit, Bella S et al. (2016) PKD1 Inhibits AMPK?2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem 291:5664-75
Frame, Nicholas M; Gursky, Olga (2016) Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks. FEBS Lett 590:866-79
Matsuura, S; Patterson, S; Lucero, H et al. (2016) In vivo magnetic resonance imaging of a mouse model of myelofibrosis. Blood Cancer J 6:e497

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