This is a renewal application for a SCHOOL-WIDE PREDOCTORAL training program, which was initiated in 2003. It is designed to train yearly six graduate students in the field of Cardiovascular Biology. Cardiovascular diseases represent the major causes of mortality and morbidity in the United States, and thus require major efforts in fundamental and translational research. The training program provides a format for the training of future scientists who will devote time and efforts in developing the tools to study and control the disease. The major goal of this application is to provide a formal research and academic training for Ph.D. as well as M.D.-Ph.D. candidates that have been carefully selected from a total pool of applicants to the medical school, thus capturing attention of competent young scientists to cardiovascular research, leading the way to a career in biomedical research. Training is offered in topics related to cardiovascular disease, including atherosclerosis, heart failure and hypertension, with application of disciplines such as physiology, pharmacology, biochemistry, molecular biology and genetics. The curriculum also includes special courses in cardiovascular biology, with equal emphasis on interdisciplinary and translational research. Trainees participate in various activities of the Whitaker Cardiovascular Institute (CVI) at our institute. The training faculty is affiliated with basic science departments, the department of Medicine and with the CVI. There are strong research interactions between members of the training program, at faculty and student levels. Each faculty has experience in teaching, all have had several trainees that have gone on to hold academic positions, and all have at least one active grant from NIH. During the funding period we were able to train graduate students with documented success in research and academic sl

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston University
Schools of Medicine
United States
Zip Code
Klimtchuk, Elena S; Prokaeva, Tatiana; Frame, Nicholas M et al. (2018) Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease. Proc Natl Acad Sci U S A 115:E6428-E6436
Mattson, Jeffrey M; Turcotte, Raphaƫl; Zhang, Yanhang (2017) Glycosaminoglycans contribute to extracellular matrix fiber recruitment and arterial wall mechanics. Biomech Model Mechanobiol 16:213-225
Klimtchuk, Elena S; Prokaeva, Tatiana B; Spencer, Brian H et al. (2017) In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis. Amyloid 24:115-122
Mattson, Jeffrey M; Zhang, Yanhang (2017) Structural and Functional Differences Between Porcine Aorta and Vena Cava. J Biomech Eng 139:
Backman, Daniel E; LeSavage, Bauer L; Shah, Shivem B et al. (2017) A Robust Method to Generate Mechanically Anisotropic Vascular Smooth Muscle Cell Sheets for Vascular Tissue Engineering. Macromol Biosci 17:
Backman, Daniel E; LeSavage, Bauer L; Wong, Joyce Y (2017) Versatile and inexpensive Hall-Effect force sensor for mechanical characterization of soft biological materials. J Biomech 51:118-122
Frame, Nicholas M; Jayaraman, Shobini; Gantz, Donald L et al. (2017) Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a ""molecular mop"" in immune response. J Struct Biol 200:293-302
Adams, Stephanie L; Benayoun, Laurent; Tilton, Kathy et al. (2017) Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer's Disease Patients. J Alzheimers Dis 60:43-56
Aquino, Patricia; Honda, Brent; Jaini, Suma et al. (2017) Coordinated regulation of acid resistance in Escherichia coli. BMC Syst Biol 11:1
Lucero, Hector A; Patterson, Shenia; Matsuura, Shinobu et al. (2016) Quantitative histological image analyses of reticulin fibers in a myelofibrotic mouse. J Biol Methods 3:

Showing the most recent 10 out of 71 publications