(Applicant?s Abstract) The genetic basis of cardiovascular diseases (CVD) and its related phenotypes is poorly defined. Advancements in the fields of molecular and statistical genetics have greatly enhanced our ability to understand the genetic etiology of complex diseases, like CVD. Several CVD genetic epidemiological studies have a wealth of well-characterized genotypic, environmental, and phenotypic data available. The Human Genome Project will have the sequence of human genomic DNA completed by 2003, an currently has abundance of data and resources to conduct analyses related to genetic and genomic contributions to CVD. There is a great demand for scientists that successfully integrate various types of data (genetic, environmental, and phenotypic). Genetic epidemiologist, rigorously trained in epidemiologic methods, statistics, and genetics are urgently needed to expand research opportunities in this emerging field. This five-year proposal, if awarded, will provide training for 3 pre-doctoral fellows and 1 post-doctoral fellowship positions. The demand for pre-doctoral fellowships, based on recent applicants to the Ph.D. program in the Division, is increasing. In addition, we currently have excellent pre-doctoral and post-doctoral candidates who would be eligible for a fellowship if the proposal is funded. The Program?s excellent facilities, large and diverse faculty, and broad research opportunities offer an outstanding training environment. The University of Minnesota two to three year fellowship program offers outstanding training opportunities in direct research experience in genetic epidemiology combined with a strong curriculum of formal course work and seminars. The participation of women and minorities is a high priority for fellowship training. The uniqueness of the training is the commitment of its faculty and the breadth and depth of existing research in family-based studies in CVD, and the combination of coursework in population, molecular, and statistical genetics. The need for qualified CVD genetic epidemiologists is urgent, and the training of scientists for research careers in CVD genetic epidemiology will help to further understanding of the complex genetic etiology of CVD.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZHL1-CSR-M (F1))
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Silsbee, Lorraine M
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University of Minnesota Twin Cities
Public Health & Prev Medicine
Schools of Public Health
United States
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Bielinski, Suzette J; Pankow, James S; Boerwinkle, Eric et al. (2008) Lack of association between uncoupling protein-2 Ala55Val polymorphism and incident diabetes in the atherosclerosis risk in communities study. Acta Diabetol 45:179-82
Bielinski, Suzette J; Pankow, James S; Foster, Catherine Leiendecker et al. (2008) Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination. Atherosclerosis 199:172-8
Djousse, Luc; Kochar, Jinesh; Hunt, Steven C et al. (2008) Relation of albuminuria to left ventricular mass (from the HyperGEN Study). Am J Cardiol 101:212-6
Sherva, Richard; Miller, Michael B; Pankow, James S et al. (2008) A whole-genome scan for stroke or myocardial infarction in family blood pressure program families. Stroke 39:1115-20
Lynch, A I; Arnett, D K; Davis, B R et al. (2007) Sex-specific effects of AGT-6 and ACE I/D on pulse pressure after 6 months on antihypertensive treatment: the GenHAT study. Ann Hum Genet 71:735-45
Rasmussen-Torvik, Laura J; Cushman, Mary; Tsai, Michael Y et al. (2007) The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study. Thromb Res 121:1-7
Lynch, Amy I; Arnett, Donna K; Pankow, James S et al. (2007) Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN Study. Hum Genet 122:33-40
Rasmussen-Torvik, L J; Pankow, J S; Jacobs, D R et al. (2007) Heritability and genetic correlations of insulin sensitivity measured by the euglycaemic clamp. Diabet Med 24:1286-9
Bielinski, S J; Pankow, J S; Miller, M B et al. (2007) Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination. Genes Immun 8:684-90
Bella, Jonathan N; Tang, Weihong; Kraja, Aldi et al. (2007) Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the Hypertension Genetic Epidemiology Network Study. Hypertension 49:453-60

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