This proposal describes a unique multidisciplinary physician-scientist training program that will be created at Baylor College of Medicine. It will be a school-wide program that is open to all clinical and basic science departments. It represents an effort at Baylor to reverse the national trend in the decline in the number of physicians who are going into academic research-oriented careers. In the last quarter of a century, a declining number of physician-scientists pursing avenues of biomedical research was noted first by James B. Wyngaarden 1977, and subsequently, repeatedly, by other leaders in biomedicine and, recently, by members of congress. We at Baylor have established a pilot program to support physicians from any of the clinical departments to undergo rigorous research training in NIH-funded basic science laboratories. We are seeking support for the Program that has been named the Molecular Medicine Scholars Physician-Scientist Training Program, and the trainees will be called Molecular Medicine Scholars. It is a multidisciplinary program that is open to physician-trainees from all clinical departments at Baylor who will train with mentors selected from nine Departments. The Program covers disease-oriented as well as fundamental research areas that are within the mission of the NHLBI. This exciting program represents a partnership between clinical and basic science departments with the clinical departments buying into the existing excellent basic research activities at Baylor and sharing expenses with the basic science departments, both sharing the common goal of training the next generation of molecular physician-scientists. We are hopeful that the Program will play a significant role in reversing the national trend of increasing numbers of well-trained physicians leaving an academic research oriented career in biomedicine.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Baylor College of Medicine
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Thacker, Stephen; Moran, Ana; Lionakis, Mihalis et al. (2014) Restoration of lung surfactant protein D by IL-6 protects against secondary pneumonia following hemorrhagic shock. J Infect 68:231-41
Kojima, Hideto; Kim, Jongoh; Chan, Lawrence (2014) Emerging roles of hematopoietic cells in the pathobiology of diabetic complications. Trends Endocrinol Metab 25:178-87
Maiellaro-Rafferty, K; Wansapura, J P; Mendsaikhan, U et al. (2013) Altered regional cardiac wall mechanics are associated with differential cardiomyocyte calcium handling due to nebulette mutations in preclinical inherited dilated cardiomyopathy. J Mol Cell Cardiol 60:151-60
Gutierrez, Absalon D; Balasubramanyam, Ashok (2012) Dysregulation of glucose metabolism in HIV patients: epidemiology, mechanisms, and management. Endocrine 41:1-10
Jeyaraj, Darwin; Haldar, Saptarsi M; Wan, Xiaoping et al. (2012) Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature 483:96-9
McCauley, Mark D; Wang, Tiannan; Mike, Elise et al. (2011) Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci Transl Med 3:113ra125
Moran, Ana; Thacker, Stephen A; Arikan, Ayse Akcan et al. (2011) IL-6-mediated activation of Stat3ýý prevents trauma/hemorrhagic shock-induced liver inflammation. PLoS One 6:e21449
Samson, S L; Sathyanarayana, P; Jogi, M et al. (2011) Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial. Diabetologia 54:3093-100
McCauley, Mark D; Wehrens, Xander H T (2011) Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin 32:749-57
van Oort, Ralph J; McCauley, Mark D; Dixit, Sayali S et al. (2010) Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation 122:2669-79

Showing the most recent 10 out of 20 publications