This is a resubmission of a competitive renewal application for a PHS Institutional National Service Award (T32 HL66992) at the David Geffen School of Medicine at UCLA to prepare post-doctoral fellows for an academic career in Hematology. This award was initiated in July, 2002, and supports 4 fellowship slots in years 2 and 3 of Hematology/Medical Oncology training. The Program Director is Victor Marder, MD, and the Associate Program Director is Donald Kohn, MD. In keeping with the NHLBI mission for training fellows in non-malignant hematology, we have made significant changes in our program regarding leadership, research foci, and selection of and funding of fellows for their research years of training. Of note are 1) the appointment of a pediatric hematology fellow who will study gene transplantation in sickle cell disease, 2) the elimination of an existing research focus in Leukemia, and 3) re-organization of Training Grant leadership to reflect our focus on non-malignant hematology. Since 2002, 22 fellows have completed their fellowship at UCLA, 15 of which (68%) are actively involved in research, 12 (55%) as full-time faculty at a University or Medical Center or in a full-time research position in industry, and 3 with active clinical research programs as part of their practice, including 2 who have voluntary university appointments. In the last 3 years (2010-2012), 7 of 8 graduates (87.5%) entered full- or part-time university or industry positions of research. All fellows entering the program are Training Grant Eligible (TGE). The faculty consists of 31 academic scientists and physicians, 89% of whom have NIH grant funding, grouped into 3 research foci, Hematopoiesis and Stem Cell Biology (Don Kohn, MD, Director), Lymphocyte Biology (John Timmerman, MD, Director) and Coagulation and Vascular Biology (Victor Marder, MD, Director). Interaction with other training programs in complementary disciplines, notably those in the Broad Stem Cell Research Center, the T32 Training Grant in Developmental Hematology, and the NCI T32 Training Grant in Medical Oncology, emphasizes the resources available to meet our mission of basic and translational research careers. A core curriculum is offered to all fellows, including a "Clinical Research Course", which covers subjects on research design and analysis, ethics, regulatory issues, grant preparation and responsible conduct of research. Fellows are encouraged to obtain an advanced degree as part of the STAR program, and 2 have obtained the Master's degree and 2 a PhD degree. Formal review of the mentor's effectiveness and the fellow's achievements are prepared by the Steering Committee, made up of the 3 Focus Directors, the PI of the Division Oncology Training Grant (Antoni Ribas, MD, PhD), and the Director of the Division Fellowship Training Program (Arash Naeim, MD, PhD). Three research retreats are held each year, fall retreats at which first year research proposals are proposed and second year progress reports are reviewed, and a spring retreat for final reports of graduating fellows. We are proud of our success in training underrepresented Minority candidates, 3 of 13 (23%) since 2007 being Hispanic or African-American.

Public Health Relevance

TO PUBLIC HEALTH STATEMENT: This program entitled Training for Academic Hematology is devoted to the education and professional training of post-doctoral physician-scientists for careers in University-based research and education. The emphasis of this program is on non-malignant hematology, which includes broad areas of bleeding and clotting disorders, gene therapy of hereditary conditions such as sickle cell disease, and insights into basic mechanisms for the control, maturation and function of bone marrow, lymph node and blood cells.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL066992-11A1
Application #
8551020
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
2001-08-01
Project End
2018-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
11
Fiscal Year
2013
Total Cost
$266,542
Indirect Cost
$19,962
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kohn, Lisa A; Seet, Christopher S; Scholes, Jessica et al. (2014) Human lymphoid development in the absence of common ?-chain receptor signaling. J Immunol 192:5050-8
Scheuner, Maren T; de Vries, Han; Kim, Benjamin et al. (2009) Are electronic health records ready for genomic medicine? Genet Med 11:510-7
Andorsky, David J; Timmerman, John M (2008) Interleukin-21: biology and application to cancer therapy. Expert Opin Biol Ther 8:1295-307
Bucher, N; Britten, C D (2008) G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer. Br J Cancer 98:523-8
Marder, Victor J (2008) Pre-clinical studies of plasmin: superior benefit-to-risk ratio of plasmin compared to tissue plasminogen activator. Thromb Res 122 Suppl 3:S9-S15
Jahan, Reza; Stewart, Daphne; Vinters, Harry V et al. (2008) Middle cerebral artery occlusion in the rabbit using selective angiography: application for assessment of thrombolysis. Stroke 39:1613-5
Garon, Edward B; Marcu, Laura; Luong, Quang et al. (2007) Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells. Leuk Res 31:643-51
Garon, Edward B; Sawcer, David; Vernier, P Thomas et al. (2007) In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies. Int J Cancer 121:675-82
Stewart, D; Marder, V J; Starkman, S et al. (2006) Magnesium sulfate neither potentiates nor inhibits tissue plasminogen activator-induced thrombolysis. J Thromb Haemost 4:1575-9
Riedl, Karen; Krysan, Kostyantyn; Pold, Mehis et al. (2004) Multifaceted roles of cyclooxygenase-2 in lung cancer. Drug Resist Updat 7:169-84