This is the first competitive renewal application for this clinical cardiovascular T32 training grant, which was initially funded in 2003. For this renewal application, we have made significant changes in our program in response to the Special Emphasis Panel critique of November 2002, in response to our initial experience with the program and in response to changes in cardiovascular medicine over the last 4 years. These program changes include dropping the use of training tracks, additions to our mentor faculty, and enhancements to our didactic course offerings. The 3 objectives of this program are to provide trainees with: 1) didactic training in the methods of clinical research, 2) a mentored research experience, and 3) training and experience in """"""""survival skills"""""""" required for a successful academic career. Trainees spend 2 years in this program. During the funding period from 7/1/2003 to 6/30/2007, 5 trainees have completed the program and 3 are currently in the first year of training. Of the 5 who have finished the program, 3 have academic faculty appointments (2 at Duke, 1 at Emory). To date, this group of trainees has produced 16 first author publications in peer-reviewer journals and 4 of the trainees have applied for and been awarded extramural research funding. Formal training of participating mentors on the essentials of good mentoring will continue to be a major feature of our program. Interdisciplinary co-mentoring is standard in our training program. Twenty-eight faculty members representing 6 departments at Duke (Medicine, Surgery, Anesthesiology, Pediatrics, Behavioral Medicine/Psychiatry and Radiology) will participate as mentors in this program. During the course of each fellowship, several methods are used to monitor progress, including weekly meetings between the trainee and the primary mentor, and quarterly meetings for each trainee with the Program Director. Outcomes tracked include presentations at national meetings, peer-reviewed publications, and at least one grant application. We are requesting 6 trainee slots at the post-doctoral level, an increase from our currently funded level of 3 slots per year. In the application year 2006, we received 500 applications for Cardiovascular Training and interviewed 60 candidates. Of these, 52 were training grant eligible and 35 were seeking training in clinical research. We therefore feel that we have the critical mass of high quality candidates, outstanding mentors and a rich diversity of clinical research resources to support an increase in the size of our program.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL069749-10
Application #
8286246
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
2002-07-01
Project End
2014-01-31
Budget Start
2012-07-01
Budget End
2014-01-31
Support Year
10
Fiscal Year
2012
Total Cost
$243,482
Indirect Cost
$24,061
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Greene, Stephen J; Felker, G Michael; Butler, Javed (2018) Outpatient versus inpatient worsening heart failure: distinguishing biology and risk from location of care. Eur J Heart Fail :
Greene, Stephen J; Mentz, Robert J (2018) Potential advantages of torsemide in patients with heart failure: more than just a 'water pill'? Eur J Heart Fail 20:471-473
Mandawat, Aditya; Newby, L Kristin (2018) High-Sensitivity Troponin in Noncardiac Surgery: Pandora's Box or Opportunity for Precision Perioperative Care? Circulation 137:1233-1235
Greene, Stephen J; Fonarow, Gregg C; Solomon, Scott D et al. (2018) Relationship between timing of trial randomization, protocol completion, and clinical outcomes among patients hospitalized for heart failure: from the ASTRONAUT trial. Eur J Heart Fail :
Zeitler, Emily P; Sanders, Gillian D; Singh, Kavisha et al. (2018) Single vs. dual chamber implantable cardioverter-defibrillators or programming of implantable cardioverter-defibrillators in patients without a bradycardia pacing indication: systematic review and meta-analysis. Europace 20:1621-1629
Greene, Stephen J; Felker, G Michael (2018) Considering the duration of heart failure: using the past to predict the future. Eur J Heart Fail 20:382-384
Vaduganathan, Muthiah; Patel, Ravi B; Mentz, Robert J et al. (2018) Sudden Death After Hospitalization for Heart Failure With Reduced Ejection Fraction (from the EVEREST Trial). Am J Cardiol 122:255-260
Greene, Stephen J; Vaduganathan, Muthiah; Khan, Muhammad Shahzeb et al. (2018) Prevalent and Incident Heart Failure in Cardiovascular Outcome Trials of Patients With Type 2 Diabetes. J Am Coll Cardiol 71:1379-1390
Patel, Ravi B; Vaduganathan, Muthiah; Greene, Stephen J et al. (2018) Nomenclature in heart failure: a call for objective, reproducible, and biologically-driven terminology. Eur J Heart Fail 20:1379-1381
Jawitz, Oliver K; Keenan, Jeffrey E; Perna, Jennifer et al. (2018) Successful aneurysm resection and coronary artery revascularization following saphenous vein graft aneurysm rupture. Eur J Cardiothorac Surg :

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