The overarching goal of this NRSA application is to provide a high quality, mentored training experience to develop future thought leaders in cardiovascular clinical research. We will conduct national searches to attract the most promising post-doctoral cardiology fellows into a rigorous clinical research training program that will provide: 1) rigorous didactic training in the methods of clinical research, 2) closely mentored rea world research experience, and 3) structured training and experience in """"""""survival skills"""""""" required for a successful academic career. Trainees will spend at least 2 years in this program and devote 100% effort to the program while they are supported. We are requesting 6 trainee slots at the post-doctoral level. We have selected mentors for the program from among the thought leaders in cardiovascular clinical research at Duke. Ongoing assessment and training of participating faculty mentors on the essentials of good mentoring will be a major feature of our program. Interdisciplinary co-mentoring will be required, with each trainee co-mentored by a methodologist. In addition, trainees will be able to select additional co-mentors from among the excellent faculty participating in this program as well as from among other Duke faculty, depending on each trainee's needs and research interests. For each trainee, several methods will be used to monitor progress, including the creation of a formal Individual Development Plan that will be reviewed regularly by a Scientific Oversight Committee and annually by an External Advisory Board. Outcomes expected from each fellow accepted into this T32 program will include scientific presentations at research conferences/symposia and at national meetings, peer-reviewed publications, an independent research project, and at least one grant application to support the trainee's post-fellowship research. The Program Directors and faculty will assist each graduate in obtaining a faculty position in academics and will further guide and support them as they transition to independent investigators. The proposed NRSA program will organize the abundant resources available at Duke for clinical research into a focused and efficient program for training the cardiovascular clinical research thought leaders of the future.
The purpose of this grant is to train the next generation of thought leaders in cardiovascular clinical research. These clinical researches will bring scientific advancements in the care of patients with cardiovascular disease from bench to bedside through the translation of promising early-phase therapies/treatments into large-scale human testing and will lead research efforts in the comparative effectiveness of new and existing therapies, optimizing systems of care to promote high quality treatment patterns, and epidemiological study. Trainees supported by this grant are expected to make major scientific contributions to medicine in their academic research careers and have a significant impact on public health.
|Khazanie, Prateeti; Liang, Li; Curtis, Lesley H et al. (2016) Clinical Effectiveness of Hydralazine-Isosorbide Dinitrate Therapy in Patients With Heart Failure and Reduced Ejection Fraction: Findings From the Get With The Guidelines-Heart Failure Registry. Circ Heart Fail 9:e002444|
|Navar, Ann Marie; Stone, Neil J; Martin, Seth S (2016) What to say and how to say it: effective communication for cardiovascular disease prevention. Curr Opin Cardiol 31:537-44|
|Khazanie, Prateeti; Greiner, Melissa A; Al-Khatib, Sana M et al. (2016) Comparative Effectiveness of Cardiac Resynchronization Therapy Among Patients With Heart Failure and Atrial Fibrillation: Findings From the National Cardiovascular Data Registry's Implantable Cardioverter-Defibrillator Registry. Circ Heart Fail 9:|
|Hemal, Kshipra; Pagidipati, Neha J; Coles, Adrian et al. (2016) Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial. JACC Cardiovasc Imaging 9:337-46|
|Cooper, Lauren B; Lu, Di; Mentz, Robert J et al. (2016) Cardiac transplantation for older patients: Characteristics and outcomes in the septuagenarian population. J Heart Lung Transplant 35:362-9|
|Zeitler, Emily P; Al-Khatib, Sana M; Slotwiner, David et al. (2016) Proceedings from Heart Rhythm Society's emerging technologies forum, Boston, MA, May 12, 2015. Heart Rhythm 13:e39-49|
|AbouEzzeddine, Omar F; Lala, Anuradha; Khazanie, Prateeti P et al. (2016) Evaluation of a provocative dyspnea severity score in acute heart failure. Am Heart J 172:34-41|
|Friedman, Daniel J; Parzynski, Craig S; Varosy, Paul D et al. (2016) Trends and In-Hospital Outcomes Associated With Adoption of the Subcutaneous Implantable Cardioverter Defibrillator in the United States. JAMA Cardiol 1:900-911|
|Zeitler, Emily P; Al-Khatib, Sana M; Drozda Jr, Joseph P et al. (2016) Predictable and SuStainable Implementation of National Cardiovascular Registries (PASSION) infrastructure: A think tank report from Medical Device Epidemiological Network Initiative (MDEpiNet). Am Heart J 171:64-72.e1-2|
|Pagidipati, Neha J; Hemal, Kshipra; Coles, Adrian et al. (2016) Sex Differences in Functional and CTÂ Angiography Testing in Patients With Suspected Coronary Artery Disease. J Am Coll Cardiol 67:2607-16|
Showing the most recent 10 out of 123 publications