The NIH and Academic Community in this country recognize the seriousness of the lack of MD's remaining in academic medicine in general and having careers in clinical investigation in particular. This cardiovascular research training program is designed to address this critical problem and produce research scientists and clinician/scientists prepared to meet current and future challenges in the arena of cardiovascular function and disease. As the title of the program indicates, one unique aspect of this program is an integrative approach beginning with genomics, proteomics, molecular biology, and cellular and molecular signaling - integrated with whole animal physiology, with emphasis on genetically engineered animals. The integrative approach not only involves the scientific disciplines of the faculty of this training program, but also provides the direction for training as well. For example, we will expose graduate students and postdoctoral fellows with a primary interest in cellular/molecular mechanisms to physiology, so that they understand the target for research is ultimately cardiovascular disease such as heart failure and myocardial ischemia. Conversely, an important component of the postdoctoral program is to include M.D. and M.D./Ph.D. students who have finished, or are in the midst of their clinical training with plans for a clinical cardiology fellowship, and expose them to an in-depth two to three year training program in molecular/cellular biology. The goal of this part of the program is to train academic, clinician/scientists cardiologists to remain in the University setting to conduct full time, clinical care, research and teaching To these ends, we have a group of well funded mentors, with additional training faculty from the New Jersey Medical School (NJMS) and New Jersey Institute of Technology (NJIT), who will work together to make this program successful. This program has relevance to Public Health at several levels. First of all, it must be appreciated that cardiovascular disease is a major health problem, as it is the major cause of disability and death in the U.S. To gain knowledge regarding the pathogenesis of these diseases and their therapy it will be necessary to have research scientists trained in cardiovascular research for the 21^'century. This training program will help provide the next generation of trained cardiovascular scientists and clinician scientists.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
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NHLBI Institutional Training Mechanism Review Committee (NITM)
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Carlson, Drew E
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Rutgers University
Anatomy/Cell Biology
Schools of Medicine
United States
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Lai, Lo; Yan, Lin; Gao, Shumin et al. (2013) Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway. Circulation 127:1692-701
Bravo, Claudio; Kudej, Raymond K; Yuan, Chujun et al. (2013) Metabolomic analysis of two different models of delayed preconditioning. J Mol Cell Cardiol 55:19-26
Sehgel, Nancy L; Zhu, Yi; Sun, Zhe et al. (2013) Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension. Am J Physiol Heart Circ Physiol 305:H1281-7
Ramachandran, Jayalakshmi; Schneider, Joel S; Crassous, Pierre-Antoine et al. (2013) Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters. Biochem J 449:133-42
Elson, G; Eisenberg, M; Garg, C et al. (2013) Induction of murine adenosine A(2A) receptor expression by LPS: analysis of the 5' upstream promoter. Genes Immun 14:147-53
Vitale, Joseph M; Schneider, Joel S; Beck, Amanda J et al. (2012) Dystrophin-compromised sarcoglycan-ýý-knockout diaphragm requires full wild-type embryonic stem cell reconstitution for correction. J Cell Sci 125:1807-13
Umemura, Masanari; Ho, David; Nozawa, Naoki et al. (2012) Acute myocardial infarction with isolated conus branch occlusion. J Electrocardiol 45:285-7
Iwatsubo, Kosaku; Bravo, Claudio; Uechi, Masami et al. (2012) Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase. Am J Physiol Heart Circ Physiol 302:H2622-8
Zhao, Xin; Park, Jiyeon; Ho, David et al. (2012) Cardiomyocyte overexpression of the *1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning. Am J Physiol Heart Circ Physiol 302:H1614-24
Gelpi, Ricardo J; Park, Misun; Gao, Shumin et al. (2011) Apoptosis in severe, compensated pressure overload predominates in nonmyocytes and is related to the hypertrophy but not function. Am J Physiol Heart Circ Physiol 300:H1062-8

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