This proposal represents a revised connpetitive renewal application for support of research training in cardiovascular science at the University of Minnesota. The ainn of this proposal is to provide rigorous research training in cardiovascular science to prepare candidates for a career in academic cardiology or cardiovascular investigation. A comprehensive curriculum has been developed, including formal course work, as well as an intensive laboratory experience, to provide a firm foundation in the concepts and methodology of cardiovascular research. The training program has been designed to provide a multidisciplinary research experience crossing traditional disciplines to emphasize application of unique research methodology to problems of clinical importance in cardiovascular science. The proposal has been revised in response to the previous critique to respond to specific questions raised by the reviewers and to update the proposal with additional institutional commitments that further enhance the training program. In addition to research training, special attention is paid to providing instruction in written and oral presentation of laboratory data, preparation of research grants, and development of mentoring skills. MD candidates who have begun their training in clinical cardiology or who elect to perform a 3-year period of research prior to beginning their clinical cardiology training, as well as postdoctoral PhD candidates will be accepted for a 2-3 year period of intensive research training. Training opportunities have been developed in four academic theme areas: (1) cardiac development and regeneration from stem cell populations;(2) molecular and integrative cardiovascular physiology;(3) cardiovascular applications of nuclear magnetic resonance, and (4) clinical and epidemiologic studies leading to a Master of Science degree in clinical research. These specific academic themes were chosen on the basis of four considerations;(1) they are areas of current research interest in which the potential for great strides in knowledge and understanding exist;(2) they are areas in which there is demand for trained investigators and academic physicians;(3) they are areas in which there is significant depth of research expertise and facilities with stable funding to provide a comprehensive training . program at the University of Minnesota, and (4) they are areas in which interdisciplinary relationships already exist, thus ensuring trainee involvement in a multidisciplinary collaborative research experience. The long- term goal of this program is to provide a continuing stream of physician scientists and basic investigators working in cardiovascular science who are trained to use state-of-the-art technology to explore important research topics and successfully compete for independent grant funding.

Public Health Relevance

This grant is to provide funds for state of the art training of physicians and post doctoral students in cardiovascular research.
The aim of the proposal is to supply a continuing stream of scientists working in areas relevant to heart disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL069764-10
Application #
8469544
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Carlson, Drew E
Project Start
2002-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$262,826
Indirect Cost
$23,322
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Kwon, Younghoon; Jacobs Jr, David R; Lutsey, Pamela L et al. (2018) ""Sleep disordered breathing and ECG R-wave to radial artery pulse delay, The Multi-Ethnic Study of Atherosclerosis"". Sleep Med 48:172-179
Kwon, Younghoon; Misialek, Jeffrey R; Duprez, Daniel et al. (2017) Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities: the MESA study. Europace 19:1759-1766
Wang, Huan; Kwak, Dongmin; Fassett, John et al. (2017) Role of bone marrow-derived CD11c+ dendritic cells in systolic overload-induced left ventricular inflammation, fibrosis and hypertrophy. Basic Res Cardiol 112:25
Kwon, Younghoon; Kazaglis, Louis; Cho, Yeilim et al. (2017) Test-Retest Reliability of Two Consecutive Mean Sleep Latency Tests in Patients with Hypersomnia. Sleep Biol Rhythms 15:337-339
Kwon, Younghoon; Koene, Ryan J; Kwon, Osung et al. (2017) Effect of Sleep-Disordered Breathing on Appropriate Implantable Cardioverter-Defibrillator Therapy in Patients With Heart Failure: A Systematic Review and Meta-Analysis. Circ Arrhythm Electrophysiol 10:e004609
Rebbeck, Robyn T; Nitu, Florentin R; Rohde, David et al. (2016) S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine ReceptorĀ·Calmodulin Complex. J Biol Chem 291:15896-907
Gomez-Hurtado, Nieves; Boczek, Nicole J; Kryshtal, Dmytro O et al. (2016) Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. Circ Arrhythm Electrophysiol 9:
Prins, Kurt W; Asp, Michelle L; Zhang, Huiliang et al. (2016) Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice. JACC Basic Transl Sci 1:122-130
Wang, Huan; Hou, Lei; Kwak, Dongmin et al. (2016) Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure Progression. Hypertension 68:114-22
Wang, Huan; Kwak, Dongmin; Fassett, John et al. (2016) CD28/B7 Deficiency Attenuates Systolic Overload-Induced Congestive Heart Failure, Myocardial and Pulmonary Inflammation, and Activated T Cell Accumulation in the Heart and Lungs. Hypertension 68:688-96

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