The pathogenesis of cardiovascular diseases is complex. Accordingly, we propose to train future vascular biologists capable of implementing integrated approaches combining """"""""cellular"""""""", """"""""whole animal"""""""" and """"""""human"""""""" systems through multidisciplinary collaborations that begin during pre-doctoral training. The interdisciplinary pre doctoral training program in Integrative Vascular Biology (IVB) at the University of North Carolina was established in 2002 and has effectively united graduate students who are working in broad disciplines of vascular biology. The success of the IVB Program is clearly demonstrated by the fact that 18 of the 42 trainees received individual fellowships while they were/are in training, and that 22 of 27 past trainees who completed their PhDs are continuing research in academic settings or are residents/students at Medical Schools. The program aims (1) To connect graduate students in broad areas of research related to vascular biology and to cultivate their communication and collaboration skills;(2) To facilitate collaborations through co mentors in different Departments, and thereby integrate a broad knowledge base and skill set relevant to the trainee's thesis research. This renewal application requests funding to continue our IVB Program with support for 12 trainees per year, each up to three years. A new approach in this renewal is to identify outstanding students from under-represented minority backgrounds and guide their vascular biology interest during their first year;one of the trainee positions wil be specifically assigned to support this Fellow. Other trainees will be selected among those who are already in departmental graduate programs at UNC and have chosen thesis projects/mentors in areas related to vascular biology at the end of their first or second year. To encourage a multi-disciplinary approach, we require each trainee to have a collaborating advisor(s) in addition to their conventional primary mentor. The IVB Program is administered by the campus-wide Program for Molecular Biology and Biotechnology. Dr. Nobuyo Maeda, Prof. of Pathology and Laboratory Medicine, is the Director, and Drs. Kathleen Caron, Assoc. Prof. of Cell and Molecular Physiology, and Leslie Parise, Prof. and Chair of Biochemistry and Biophysics, are the Associate Directors. The primary mentors are faculty members at UNC from 13 Departments in four Schools and one College, all of which have a strong commitment to predoctoral training through vascular biology-related research. To form a body of complementing faculty with whom the trainees can choose to collaborate, the primary training faculty are joined by clinical faculty and investigators at UNC who maintain active laboratories staffed primarily with postdoctoral fellows. Support for the IVB community is also provided through the McAlister Heart Institute which offers a seminar series and Core facilities to study vascular biology. With its outstanding history and breadth in vascular biology research, its strong group of investigators, and its strength in animal model studies, the IVB Program at UNC offers an ideal environment for the multidisciplinary training of pre-doctoral students.

Public Health Relevance

To accelerate progress in the prevention and treatment of cardiovascular disease we must expand our knowledge of the basic mechanisms and pathways underlying the complexities of vascular biology by investigating these research areas from multiple directions. The interdisciplinary pre-doctoral training program in Integrative Vascular Biology (IVB program) at the University of North Carolina proposes to train future vascular biologists capable of implementing integrated approaches that combine cellular, whole animal and human systems through multidisciplinary collaborations that begin during pre-doctoral training. With its outstanding history in vascular biology research, its strong group of investigators, and its strength in animal model studies, the IVB Program at UNC offers an outstanding environment for multidisciplinary training of pre-doctoral students in broadly based areas of vascular biology-related research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
2T32HL069768-11A1
Application #
8338292
Study Section
Special Emphasis Panel (ZHL1-CSR-F (F3))
Program Officer
Scott, Jane
Project Start
2002-04-01
Project End
2017-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
11
Fiscal Year
2012
Total Cost
$383,790
Indirect Cost
$24,316
Name
University of North Carolina Chapel Hill
Department
Pathology
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Zhao, Liyang; Cozzo, Alyssa J; Johnson, Amy R et al. (2017) Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice. Atherosclerosis 266:182-189
Lindsey, Brooks D; Shelton, Sarah E; Martin, K Heath et al. (2017) High Resolution Ultrasound Superharmonic Perfusion Imaging: In Vivo Feasibility and Quantification of Dynamic Contrast-Enhanced Acoustic Angiography. Ann Biomed Eng 45:939-948
Davis, Reema B; Kechele, Daniel O; Blakeney, Elizabeth S et al. (2017) Lymphatic deletion of calcitonin receptor-like receptor exacerbates intestinal inflammation. JCI Insight 2:e92465
Kao, Yu-Chieh Jill; Oyarzabal, Esteban A; Zhang, Hua et al. (2017) Role of Genetic Variation in Collateral Circulation in the Evolution of Acute Stroke: A Multimodal Magnetic Resonance Imaging Study. Stroke 48:754-761
Haskell, Gloria T; Jensen, Brian C; Samsa, Leigh Ann et al. (2017) Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease. Circ Cardiovasc Genet 10:
Ravi, Saranya; Schuck, Robert N; Hilliard, Eleanor et al. (2017) Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease. Am J Pathol 187:2895-2911
Kennedy, Leslie; Kaltenbrun, Erin; Greco, Todd M et al. (2017) Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis. PLoS Genet 13:e1007011
Torres, Gabriela; Czernuszewicz, Tomasz J; Homeister, Jonathon W et al. (2017) ARFI variance of acceleration (VoA) for noninvasive characterization of human carotid plaques in vivo. Conf Proc IEEE Eng Med Biol Soc 2017:2984-2987
Vaseghi, Haley; Liu, Jiandong; Qian, Li (2017) Molecular barriers to direct cardiac reprogramming. Protein Cell 8:724-734
Pawlak, J B; Wetzel-Strong, S E; Dunn, M K et al. (2017) Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice. Peptides 88:1-7

Showing the most recent 10 out of 153 publications