Abstract

? ? This application describes a plan to create a major, integrated research training program in cardiovascular research at the New England Medical Center (NEMC) and Tufts University School of Medicine (TUSM). Over the past nine years, enormous growth in the training resources for cardiovascular biology has occurred at our Institution. Six elements are integrated in this proposal to create a training experience highly responsive to the NHLBI areas of focus for such programs, emphasizing multidisciplinary training, and collaborative research opportunities. These six elements include the existing NEMC-TUSM research environment, the Molecular Cardiology Research Institute, the Cardiology Division of the Department of Medicine, the NHLBI-funded SCOR in Ischemic Heart Disease, the highly developed emphasis and resources for training at NEMC-TUSM, and the extensive existing collaborative interactions between NEMC and TUSM Departments. The commitment of the Institution to training Cardiovascular research investigators is clear and strong. This program will train 3 postdoctoral M.D. and/or Ph.D. fellows per year for 3 years (reaching a stasis of 9 trainees/year in years 3-5) in either (a) basic cellular and molecular research in the cardiovascular system, or (b) translational cardiovascular research. Tremendous growth in basic and translational research, with arrival of new, independent scientists in cardiovascular biology, has occurred at NEMC and TUSM in the past eight years. Enormous local and national interest in cardiovascular training opportunities have arisen at NEMC-TUSM during this time. Thus, there is an enormous training opportunity at present, but a carefully structured cardiovascular research training program ? does not exist. The program proposed here is multidisciplinary, exposes trainees to collaborative research, and places a major emphasis on mentoring. Furthermore, it places a high priority on translational cardiovascular research and incorporates several unique approaches to ensuring adequate representation of diversity. This Training Program in Cardiovascular Research is exemplary of the approach that the NHLBI seeks to develop to train the next generation of cardiovascular scientists. (End of Abstract) ? ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL069770-04
Application #
7077607
Study Section
Special Emphasis Panel (ZHL1-CSR-M (F1))
Program Officer
Scott, Jane
Project Start
2003-08-01
Project End
2008-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
4
Fiscal Year
2006
Total Cost
$611,784
Indirect Cost

  Institution

Name
Tufts University
Department
Type
DUNS #
079532263
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Morine, Kevin J; Qiao, Xiaoying; York, Sam et al. (2018) Bone Morphogenetic Protein 9 Reduces Cardiac Fibrosis and Improves Cardiac Function in Heart Failure. Circulation 138:513-526
Upshaw, Jenica N; Konstam, Marvin A; Klaveren, David van et al. (2016) Multistate Model to Predict Heart Failure Hospitalizations and All-Cause Mortality in Outpatients With Heart Failure With Reduced Ejection Fraction: Model Derivation and External Validation. Circ Heart Fail 9:
Salvador, Ane M; Nevers, Tania; Velázquez, Francisco et al. (2016) Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload-Induced Heart Failure. J Am Heart Assoc 5:e003126
Zeiger, A S; Liu, F D; Durham, J T et al. (2016) Static mechanical strain induces capillary endothelial cell cycle re-entry and sprouting. Phys Biol 13:046006
Velázquez, Francisco; Grodecki-Pena, Anna; Knapp, Andrew et al. (2016) CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J Immunol 196:1305-1316
Paulus, Jessica K; Lai, Lana Y H; Lundquist, Christine et al. (2016) Field Synopsis of the Role of Sex in Stroke Prediction Models. J Am Heart Assoc 5:
Wessler, Benjamin S; Lai Yh, Lana; Kramer, Whitney et al. (2015) Clinical Prediction Models for Cardiovascular Disease: Tufts Predictive Analytics and Comparative Effectiveness Clinical Prediction Model Database. Circ Cardiovasc Qual Outcomes 8:368-75
Nevers, Tania; Salvador, Ane M; Grodecki-Pena, Anna et al. (2015) Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure. Circ Heart Fail 8:776-87
Durham, Jennifer T; Dulmovits, Brian M; Cronk, Stephen M et al. (2015) Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? Invest Ophthalmol Vis Sci 56:3441-59
Pruthi, Dafina; Khankin, Eliyahu V; Blanton, Robert M et al. (2015) Exposure to experimental preeclampsia in mice enhances the vascular response to future injury. Hypertension 65:863-70

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