This is a competitive renewal application for a post-doctoral Cardiovascular Training Grant (CVTG) Program centered at Tufts Medical Center (Tufts-MC) and Tufts University School of Medicine (TUSM). This CVTG provides state-of-the-art training to outstanding postdoctoral M.D. and/or Ph.D. fellows and is exemplary of the approach that the NHLBI seeks for training the next generation of CV scientists. Two broad and overlapping types of mechanistic CV research are emphasized: (1) cellular and molecular investigations of the CV system;and (2) translational, clinical studies in CV medicine. In its first five-year cycle this CVTG Program has been highly successful with 20 trainees to date, 43 peer-reviewed articles published by trainees, and two CVTG graduates now with K-grant funding. Several integrated elements make this CVTG Program a highly unique, multidisciplinary training experience: the rich training environment of the Tufts Health Sciences Campus, which includes Tufts-MC, TUSM, the Tufts Sackler Graduate School of Biomedical Sciences and the Tufts Human Nutrition Research Center, the internationally recognized Molecular Cardiology Research Institute, a major CV research department at Tufts-MC with 17 Pis and ~100 people, and the Tufts-MC Cardiology Division, with a superb group of translational researchers;the extensive portfolio of NIH-funded CV research in CVTG faculty;new training resources from the recent CTSA award;and the world-class faculty, with highly evolved collaborative interactions especially in this CVTG Program. Additional important strengths of this revised CVTG application include: 1. a special emphasis on mentoring, with each trainee being mentored by a 3-member mentoring committee with expertise spanning basic, clinical, and translational approaches, 2. a strong commitment to recruitment of highly qualified minority trainees, and 3. the inclusion of a strong and broad core curriculum. Trainees and faculty are formally evaluated on an annual basis. This program trains 4 postdoctoral M.D. and/or Ph.D. fellows per year for three years (steady-state: 12 trainees/year), with the goal of producing independent cardiovascular scientists well-equipped to lead their own research programs.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Tufts University
United States
Zip Code
DuPont, Jennifer J; Hill, Michael A; Bender, Shawn B et al. (2014) Aldosterone and vascular mineralocorticoid receptors: regulators of ion channels beyond the kidney. Hypertension 63:632-7
Doyle, Jamie R; Krishnaji, Subrahmanian T; Zhu, Guangli et al. (2014) Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. J Biol Chem 289:13385-96
Gordon, Francesca K; Vallaster, Caroline S; Westerling, Thomas et al. (2014) Research resource: Aorta- and liver-specific ER?-binding patterns and gene regulation by estrogen. Mol Endocrinol 28:1337-51
Doyle, Jamie R; Harwood, Benjamin N; Krishnaji, Subrahmanian Tarakkad et al. (2014) A two-step strategy to enhance activity of low potency peptides. PLoS One 9:e110502
Durham, Jennifer T; Surks, Howard K; Dulmovits, Brian M et al. (2014) Pericyte contractility controls endothelial cell cycle progression and sprouting: insights into angiogenic switch mechanics. Am J Physiol Cell Physiol 307:C878-92
Zhao, Jin; Imbrie, Gregory A; Baur, Wendy E et al. (2013) Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 33:257-65
Heffernan, Kevin S; Wanke, Christine A; Dong, Kimberly et al. (2013) Racial differences in central hemodynamic burden in men with HIV: preliminary findings. Ethn Dis 23:217-22
Doyle, Jamie R; Lane, Jacqueline M; Beinborn, Martin et al. (2013) Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition. J Lipid Res 54:823-30
Warner, Patrick J; Al-Quthami, Adeeb; Brooks, Erica L et al. (2013) Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas. BMC Cardiovasc Disord 13:19
Ueda, Kazutaka; Lu, Qing; Baur, Wendy et al. (2013) Rapid estrogen receptor signaling mediates estrogen-induced inhibition of vascular smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol 33:1837-43

Showing the most recent 10 out of 38 publications