This is a competitive renewal application for a post-doctoral Cardiovascular Training Grant (CVTG) Program centered at Tufts Medical Center (Tufts-MC) and Tufts University School of Medicine (TUSM). This CVTG provides state-of-the-art training to outstanding postdoctoral M.D. and/or Ph.D. fellows and is exemplary of the approach that the NHLBI seeks for training the next generation of CV scientists. Two broad and overlapping types of mechanistic CV research are emphasized: (1) cellular and molecular investigations of the CV system;and (2) translational, clinical studies in CV medicine. In its first five-year cycle this CVTG Program has been highly successful with 20 trainees to date, 43 peer-reviewed articles published by trainees, and two CVTG graduates now with K-grant funding. Several integrated elements make this CVTG Program a highly unique, multidisciplinary training experience: the rich training environment of the Tufts Health Sciences Campus, which includes Tufts-MC, TUSM, the Tufts Sackler Graduate School of Biomedical Sciences and the Tufts Human Nutrition Research Center, the internationally recognized Molecular Cardiology Research Institute, a major CV research department at Tufts-MC with 17 Pis and ~100 people, and the Tufts-MC Cardiology Division, with a superb group of translational researchers;the extensive portfolio of NIH-funded CV research in CVTG faculty;new training resources from the recent CTSA award;and the world-class faculty, with highly evolved collaborative interactions especially in this CVTG Program. Additional important strengths of this revised CVTG application include: 1. a special emphasis on mentoring, with each trainee being mentored by a 3-member mentoring committee with expertise spanning basic, clinical, and translational approaches, 2. a strong commitment to recruitment of highly qualified minority trainees, and 3. the inclusion of a strong and broad core curriculum. Trainees and faculty are formally evaluated on an annual basis. This program trains 4 postdoctoral M.D. and/or Ph.D. fellows per year for three years (steady-state: 12 trainees/year), with the goal of producing independent cardiovascular scientists well-equipped to lead their own research programs.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL069770-10
Application #
8496847
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
2002-04-01
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2013
Total Cost
$352,527
Indirect Cost
$43,850
Name
Tufts University
Department
Type
DUNS #
079532263
City
Boston
State
MA
Country
United States
Zip Code
02111
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Velázquez, Francisco; Grodecki-Pena, Anna; Knapp, Andrew et al. (2016) CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. J Immunol 196:1305-16
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Wessler, Benjamin S; Lai Yh, Lana; Kramer, Whitney et al. (2015) Clinical Prediction Models for Cardiovascular Disease: Tufts Predictive Analytics and Comparative Effectiveness Clinical Prediction Model Database. Circ Cardiovasc Qual Outcomes 8:368-75
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Durham, Jennifer T; Dulmovits, Brian M; Cronk, Stephen M et al. (2015) Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? Invest Ophthalmol Vis Sci 56:3441-59
Wessler, Benjamin S; Udelson, James E (2015) Neuronal dysfunction and medical therapy in heart failure: can an imaging biomarker help to "personalize" therapy? J Nucl Med 56 Suppl 4:20S-24S
Nevers, Tania; Salvador, Ane M; Grodecki-Pena, Anna et al. (2015) Left Ventricular T-Cell Recruitment Contributes to the Pathogenesis of Heart Failure. Circ Heart Fail 8:776-87

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