Cardiovascular disease is a substantial burden in terms of morbidity and mortality. On the other hand, the development of therapeutic approaches involving stem cell transplantation or other cardiac cell replacement therapies have never been more promising. Understanding the basis for the development of cardiovascular disease and the pathophysiological changes that come along with it is a prerequisite to translating innovative therapeutic approaches into the clinic and requires basic scientists and clinicians with a deep understanding not only for the physiology of the cardiovascular system but also an understanding for the cellular and sub- cellular basis of cardiovascular disease. These two groups must, but frequently do not, share a lingua franca, owing in part to their lack of a shared knowledge base and experiences. Therefore, the major goal of this Training Program is to provide an interdisciplinary research and training environment composed of clinical as well as basic science departments where qualified Trainees can obtain in depth knowledge in all levels of cardiovascular research. The Program is a first renewal and refinement of the previous, successful Program. The program sets out to train 4 pre-doctoral and 4 post-doctoral students a year. The Trainers selected for this Program all have a strong background in clinical and/or basic science research and are supported by federal or private research funds. A strength of this Program is the diversity of research techniques employed by the Trainers and available to the Trainees. Research focuses range from single molecule biophysics to single cell and whole organ studies, small and large animal models of disease, and human clinical research trials. Trainers are grouped into four Research Focus Groups: 1. Cardiac Electrophysiology and Arrhythmia, 2. Cardiac Mechanics, 3. Cardiac Metabolism &Cell Signaling, and 4. Tissue Remodeling. Each focus group has a clearly formulated translational research focus that should help the Trainees to bridge the gap between basic science and translational research. The goal of the Program is to provide experiences and rewards sufficient to attract, retain, and propel trainees to careers as independent cardiovascular scientists.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL072742-09
Application #
8307311
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Carlson, Drew E
Project Start
2003-08-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
9
Fiscal Year
2012
Total Cost
$458,013
Indirect Cost
$28,149
Name
University of Illinois at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Brahmanandam, Vikram; McGraw, Sloane; Mirza, Omer et al. (2014) Regression of cardiac amyloidosis after stem cell transplantation assessed by cardiovascular magnetic resonance imaging. Circulation 129:2326-8
Zimnicka, Adriana M; Tang, Haiyang; Guo, Qiang et al. (2014) Upregulated copper transporters in hypoxia-induced pulmonary hypertension. PLoS One 9:e90544
Rusu, Luiza; Andreeva, Alexandra; Visintine, David J et al. (2014) G protein-dependent basal and evoked endothelial cell vWF secretion. Blood 123:442-50
Taglieri, Domenico M; Johnson, Keven R; Burmeister, Brian T et al. (2014) The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy. J Mol Cell Cardiol 66:27-40
Bauml, Michael A; Chung, Jaehoon; Groth, John V et al. (2014) Palpitations in a 64-year-old man. Heart 100:167-8
Spindler, Matthew J; Burmeister, Brian T; Huang, Yu et al. (2013) AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to *-adrenergic-induced cardiac hypertrophy. PLoS One 8:e62705
Lowry, Jessica L; Brovkovych, Viktor; Zhang, Yongkang et al. (2013) Endothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium. J Biol Chem 288:4174-93
Profirovic, Jasmina; Strekalova, Elena; Urao, Norifumi et al. (2013) A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor. Angiogenesis 16:15-28
Liu, Man; Gu, Lianzhi; Sulkin, Matthew S et al. (2013) Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy. J Mol Cell Cardiol 54:25-34
Ansenberger-Fricano, Kristine; Ganini, Douglas; Mao, Mao et al. (2013) The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol Med 54:116-24

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