The objective of this proposal is to establish a new post-doctoral Pulmonary Sciences Research Training Program at Emory University School of Medicine. The training will be provided by a team of investigators with experience in teaching and mentoring who are members or associates of the D/vision of Pulmonary, Allergy &Critical Care Medicine at Emory. The proposed training program will establish opportunities for trainees to engage in cutting edge research involving clinical investigation or basic science research designed to elucidate the clinical, epidemiologic, cellular, biochemical and genetic events elicited in the lung by acute and chronic forms of injury, the mechanisms that lead to repair or dysrepair, and the identification of novel pathways of lung regeneration. The program will be centered in the Emory Pulmonary Division that has recently experienced tremendous growth fueled by the naming of a new division director, an increase in the number of faculty to 35 with the recruitment of outstanding MD and PhD scientists, the funding of The McKelvey Lung Transplantation Center and a new NIAAA-funded multi-investigator center grant, and the acquisition of new research space. For the past decade, members of the proposed training program have collaborated to provide a strong research experience for trainees and to foster careers in academia. The newly proposed program will emphasize a multidisciplinary approach to research, the integration of basic science with specialized translational/clinical research, excellence in mentorship, and didactic training in research and topics related to academia, and will provide attention to minority recruitment. The 15 mentors of this program will provide a broad- based multidisciplinary training environment. Participating faculty include members from the Departments of Medicine (Pulmonary and Cardiology Divisions), Pediatrics, Biochemistry, Human Genetics, Surgery, and Physiology. All have an established funding and publication record as well as documented success in training. The trainees will have the opportunity to engage in a 2-year training program that includes 3 pathways: the physician-scientist pathway with emphasis on clinical/translational research, the physician-scientist pathway with emphasis on basic science, and the post-doctoral basic science pathway for PhD trainees. After the end of their 2-year experience, the trainees will be provided the opportunity to remain in academia for a 6-month period where salary and 75% protected time is provided to continue research, and opportunities are made available to remain at Emory or pursue careers at other academic institutions. The goals of the program are to develop scientists with particular expertise in either clinical/translational investigation or basic science research who are committed to careers in academic medicine, and who have the competencies and breadth of expertise necessary for functioning as independent investigators.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL076118-09
Application #
8312543
Study Section
Special Emphasis Panel (ZHL1-CSR-R (O2))
Program Officer
Colombini-Hatch, Sandra
Project Start
2004-07-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
9
Fiscal Year
2012
Total Cost
$187,871
Indirect Cost
$19,139
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Staitieh, Bashar S; Saghafi, Ramin; Kempker, Jordan A et al. (2016) Teaching a Hypothesis-driven Physical Diagnosis Curriculum to Pulmonary Fellows Improves Performance of First-Year Medical Students. Ann Am Thorac Soc 13:489-94
Staitieh, Bashar S; Fan, Xian; Neveu, Wendy et al. (2015) Nrf2 regulates PU.1 expression and activity in the alveolar macrophage. Am J Physiol Lung Cell Mol Physiol 308:L1086-93
Cho, Michael H; Castaldi, Peter J; Hersh, Craig P et al. (2015) A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med 192:559-69
Staitieh, Bashar S; Renzoni, Elisabetta A; Veeraraghavan, Srihari (2015) Pharmacologic therapies for idiopathic pulmonary fibrosis, past and future. Ann Med 47:100-5
Greenlee, Megan M; Mitzelfelt, Jeremiah D; Duke, Billie Jeanne et al. (2015) Prolactin stimulates sodium and chloride ion channels in A6 renal epithelial cells. Am J Physiol Renal Physiol 308:F697-705
Neveu, Wendy A; Mills, Stephen T; Staitieh, Bashar S et al. (2015) TGF-β1 epigenetically modifies Thy-1 expression in primary lung fibroblasts. Am J Physiol Cell Physiol 309:C616-26
Dodd, James W; Novotny, Paul; Sciurba, Frank C et al. (2015) Executive Function, Survival, and Hospitalization in Chronic Obstructive Pulmonary Disease. A Longitudinal Analysis of the National Emphysema Treatment Trial (NETT). Ann Am Thorac Soc 12:1473-81
Kaplan, Robert M; Sun, Qiankun; Ries, Andrew L (2015) Quality of well-being outcomes in the National Emphysema Treatment Trial. Chest 147:377-87
Staitieh, Bashar S; Egea, Eduardo E; Fan, Xian et al. (2015) Activation of Alveolar Macrophages with Interferon-γ Promotes Antioxidant Defenses via the Nrf2-ARE Pathway. J Clin Cell Immunol 6:
Cho, Michael H; McDonald, Merry-Lynn N; Zhou, Xiaobo et al. (2014) Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med 2:214-25

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