Research in vascular biology and cardiovascular science is rapidly progressing. At the same time, however, physician scientists have increasing clinical responsibilities which they must personally attend to in order to fulfill reimbursement an insurance requirements. Additionally, with the aging of the population, the number of patients with vascular disease is increasing. Thus, there is less time for research in vascular biology and cardiovascular science and fewer physician scientists are advancing the discipline. With this background, it is clear that proper training in research in vascular biology and cardiovascular science is critical for those physician scientists who will be the leaders in our field over the net decade(s). The current proposal is a continuation of the successful T-32 program providing research training in vascular biology, now completing 10 years in existence Vascular Surgery: Research Training in Vascular Biology. The program provides MD trainees with a basic science/translational science curriculum, or a health services outcomes science curriculum. A great strength of the program is the cross fertilization between the two curricula with common elements of training for both pathways. Training is centered at the new North Campus Research Complex (NCRC) and at the University of Michigan Samuel and Jean Frankel Cardiovascular Center. The North Campus Research Complex is one-of-a-kind, with U-M resources and crucial scientific core facilities, NCRC's environment is specifically designed to foster collaboration and innovation. NCRC has 28 buildings comprising 2.1 million square feet of office, research and manufacturing space acquired from Pfizer in 2009. Opening in 2007 the Cardiovascular Center localizes all primary services included in the care and treatment of cardiovascular disease. Faculty for the program come from multiple disciplines including Vascular Surgery, General Surgery, Cardiac Surgery, Internal Medicine, Cardiovascular Medicine, Emergency Medicine, Human Genetics, and Pathology. There is a didactic component to the proposal, in addition to the trainee working intensely with individual scientists from the Program Faculty. The common thread in this program is the emphasis on the study of vascular biology and cardiovascular science with the ultimate goal to provide the next generation of leaders in academic vascular biology and cardiovascular science.

Public Health Relevance

Research in vascular biology is rapidly progressing. At the same time, however, physician scientists in training have increasing competing responsibilities which they must personally attend to and time for research training has diminished. Additionally, with the aging of the population, the number of patients with vascular disease is increasing. The proposed program, with its emphasis on vascular biology, vascular pathology and a multi- disciplinary focus, aims to produce the next generation of clinician-scientist leaders who will pave the way to new discoveries in vascular biology.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL076123-15
Application #
9609476
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Lidman, Karin Fredriksson
Project Start
2004-04-01
Project End
2019-11-30
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
15
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Surgery
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Sutzko, Danielle C; Andraska, Elizabeth A; Obi, Andrea T et al. (2018) Risk Factors Associated with Perioperative Myocardial Infarction in Major Open Vascular Surgery. Ann Vasc Surg 47:24-30
Sutzko, Danielle C; Obi, Andrea T; Kimball, Andrew S et al. (2018) Clinical outcomes after varicose vein procedures in octogenarians within the Vascular Quality Initiative Varicose Vein Registry. J Vasc Surg Venous Lymphat Disord 6:464-470
Sutzko, Danielle C; Andraska, Elizabeth A; Gonzalez, Andrew A et al. (2018) Examining variation in Medicare payments and drivers of cost for carotid endarterectomy. J Surg Res 228:299-306
Kimball, Andrew; Schaller, Matthew; Joshi, Amrita et al. (2018) Ly6CHi Blood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes Mellitus. Arterioscler Thromb Vasc Biol 38:1102-1114
Sutzko, Danielle C; Georgoff, Patrick E; Obi, Andrea T et al. (2018) The association of venous thromboembolism chemoprophylaxis timing on venous thromboembolism after major vascular surgery. J Vasc Surg 67:262-271.e1
Obi, Andrea T; Andraska, Elizabeth; Kanthi, Yogendra et al. (2017) Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. Thromb Haemost 117:339-348
Kimball, Andrew S; Joshi, Amrita; Carson 4th, William F et al. (2017) The Histone Methyltransferase MLL1 Directs Macrophage-Mediated Inflammation in Wound Healing and Is Altered in a Murine Model of Obesity and Type 2 Diabetes. Diabetes 66:2459-2471
Davis, Frank M; Sutzko, Danielle C; Grey, Scott F et al. (2017) Predictors of surgical site infection after open lower extremity revascularization. J Vasc Surg 65:1769-1778.e3
Kimball, Andrew S; Joshi, Amrita D; Boniakowski, Anna E et al. (2017) Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing. Front Immunol 8:635
Sutzko, Danielle C; Andraska, Elizabeth A; Obi, Andrea T et al. (2017) Age is not a barrier to good outcomes after varicose vein procedures. J Vasc Surg Venous Lymphat Disord 5:647-657.e1

Showing the most recent 10 out of 38 publications