NIH has identified the need for additional research in various areas of lung pathobiology, including pulmonary hypertension, acute lung injury and the contribution of endothelial cell heterogeneity to these diseases. These clinical problems are multifactorial, suggesting that the development of more in-depth understanding of the underlying mechanisms will require a workforce of investigators with new interdisciplinary approaches. However, the number of NIH-funded institutional predoctoral training programs that specifically seeks to supply pulmonary fellowship and postdoctoral training programs with highly qualified doctoral students is relatively few, particularly in the 6-state Southeast Region. Our application addresses this void by providing a state-of-the-art academic program in the region for predoctoral students planning a career in cell signaling and lung biology. The infrastructure for this training program is provided by the Center for Lung Biology at the University of South Alabama College of Medicine, an interdisciplinary core curriculum in Basic Medical Sciences Ph.D. program, and a well-funded and nationally-recognized training faculty who bring a breadth of research and training expertise. Collectively, these faculty will be able to provide outstanding predoctoral training at the interface between cell signaling and lung pathobiology. The training program will provide positions for 4 predoctoral students in the first year of the program and 6 students in each subsequent year, and supported for a minimum of two and a maximum of three years. In addition to the requirement for formal academic coursework focusing on lung biology, lung pathophysiology, and signaling mechanisms, trainees will participate the seminar series and research-in-progress forums organized by the Center for Lung Biology. The proposed training program will provide a vibrant academic research environment for predoctoral students. Our goal is to provide the pulmonary research community with a rich resource of well-trained candidates for competitive postdoctoral positions.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL076125-10
Application #
8423014
Study Section
Special Emphasis Panel (ZHL1-CSR-R (O2))
Program Officer
Colombini-Hatch, Sandra
Project Start
2004-04-01
Project End
2014-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
10
Fiscal Year
2013
Total Cost
$202,664
Indirect Cost
$15,012
Name
University of South Alabama
Department
Biology
Type
Schools of Medicine
DUNS #
172750234
City
Mobile
State
AL
Country
United States
Zip Code
36688
Obiako, Boniface; Calchary, Wendy; Xu, Ningyong et al. (2013) Bicarbonate disruption of the pulmonary endothelial barrier via activation of endogenous soluble adenylyl cyclase, isoform 10. Am J Physiol Lung Cell Mol Physiol 305:L185-92
Balczon, Ron; Prasain, Nutan; Ochoa, Cristhiaan et al. (2013) Pseudomonas aeruginosa exotoxin Y-mediated tau hyperphosphorylation impairs microtubule assembly in pulmonary microvascular endothelial cells. PLoS One 8:e74343
Das, Priyanka; Basu, Abhijit; Biswas, Aditi et al. (2013) Insights into the mechanism of ribosomal incorporation of mammalian L13a protein during ribosome biogenesis. Mol Cell Biol 33:2829-42
Rich, Thomas C; Britain, Andrea L; Stedman, Tiffany et al. (2013) Hyperspectral imaging of FRET-based cGMP probes. Methods Mol Biol 1020:73-88
Ochoa, Cristhiaan D; Stevens, Troy (2012) Studies on the cell biology of interendothelial cell gaps. Am J Physiol Lung Cell Mol Physiol 302:L275-86
Musiyenko, Alla; Majumdar, Tanmay; Andrews, Joel et al. (2012) PRMT1 methylates the single Argonaute of Toxoplasma gondii and is important for the recruitment of Tudor nuclease for target RNA cleavage by antisense guide RNA. Cell Microbiol 14:882-901
Swedan, Samer; Andrews, Joel; Majumdar, Tanmay et al. (2011) Multiple functional domains and complexes of the two nonstructural proteins of human respiratory syncytial virus contribute to interferon suppression and cellular location. J Virol 85:10090-100
Basu, Abhijit; Das, Priyanka; Chaudhuri, Sujan et al. (2011) Requirement of rRNA methylation for 80S ribosome assembly on a cohort of cellular internal ribosome entry sites. Mol Cell Biol 31:4482-99
Ochoa, Cristhiaan D; Stevens, Troy; Balczon, Ron (2011) Cold exposure reveals two populations of microtubules in pulmonary endothelia. Am J Physiol Lung Cell Mol Physiol 300:L132-8
Amable, Lauren; Grankvist, Nina; Largen, Jason W et al. (2011) Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1). J Biol Chem 286:40413-22

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