We seek continued NIH support for our Training Program in cardiac imaging research. Funds are requested to support 8 fellows annually. Our program emphasizes the education of basic (PhD) and clinical (MD) scientists in modern cardiac magnetic resonance (MR), positron emission tomography (PET) and computed tomography (CT) imaging science. Our goal is to develop future leaders of cardiac imaging, emphasizing novel developmental and translational research. The training program, based in the MGH Cardiac MR-PET-CT Program, is a joint cardiology and radiology program, a model which greatly enhances opportunities for collaboration. The curriculum consists of didactic lectures including the clinical effectiveness course at the Harvard School of Public Health, laboratory exercises and individual research projects. A major strength of the Program is our outstanding faculty, each of whom are pursuing research at the cutting-edge of cardiac imaging science. The faculty consists of 21 MD and/or PhD scientists with expertise in cardiology, radiology, physics, computer science and outcomes research. Collectively they have over 50 active extramural grants and have supervised over 250 pre/post doctoral fellows in various aspects of basic and clinical cardiac imaging research. Extensive collaboration among the faculty, trainees, and accomplished investigators throughout the MGH, Harvard Medical School and MIT communities, further increase the Program's scientific impact. Broad exposure to highly motivated scientists and committed mentors, with an emphasis on individual scientific excellence, provide the conditions for the successful training of leaders in the use of these important technologies in cardiology. During the initial four years of NIH support, all NIH trainee positions were filled, and trainees authored or coauthored over 50 peer-reviewed publications. All finished trainees obtained staff positions in academic medical centers or continued in academic training programs. To enhance the program we have added technical faculty and novel equipment offering additional research opportunities for trainees in evolving areas of cardiac imaging science including FDG PET imaging of plaque activity, molecular imaging using optical and MR probes, 9.4T imaging of animal models, novel cardiac image reconstruction approaches and simultaneous imaging of stenosis and function during chemical stress using a dual source cardiac CT.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL076136-08
Application #
8113924
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Roltsch, Mark
Project Start
2004-07-01
Project End
2014-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
8
Fiscal Year
2011
Total Cost
$332,117
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Pursnani, Amit; Massaro, Joseph M; D'Agostino Sr, Ralph B et al. (2017) Guideline-Based Statin Eligibility, Cancer Events, and Noncardiovascular Mortality in the Framingham Heart Study. J Clin Oncol 35:2927-2933
Hedgire, Sandeep S; Osborne, Michael; Verdini, Daniel J et al. (2017) Updates on Stress Imaging Testing and Myocardial Viability With Advanced Imaging Modalities. Curr Treat Options Cardiovasc Med 19:26
Janjua, Sumbal A; Staziaki, Pedro V; Szilveszter, Balint et al. (2017) Presence, Characteristics, and Prognostic Associations of Carotid Plaque Among People Living With HIV. Circ Cardiovasc Imaging 10:
Meyersohn, Nandini M; Szilveszter, Balint; Staziaki, Pedro V et al. (2017) Coronary CT angiography in the emergency department utilizing second and third generation dual source CT. J Cardiovasc Comput Tomogr 11:249-257
Bittner, Daniel O; Mayrhofer, Thomas; Bamberg, Fabian et al. (2017) Impact of Coronary Calcification on Clinical Management in Patients With Acute Chest Pain. Circ Cardiovasc Imaging 10:
Lu, Michael T; Onuma, Oyere K; Massaro, Joseph M et al. (2016) Lung Cancer Screening Eligibility in the Community: Cardiovascular Risk Factors, Coronary Artery Calcification, and Cardiovascular Events. Circulation 134:897-9
Hemal, Kshipra; Pagidipati, Neha J; Coles, Adrian et al. (2016) Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial. JACC Cardiovasc Imaging 9:337-46
Pagidipati, Neha J; Hemal, Kshipra; Coles, Adrian et al. (2016) Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease. J Am Coll Cardiol 67:2607-16
Lo, Janet; Lu, Michael T; Kim, Elli A et al. (2016) Statin Effects to Reduce Hepatosteatosis as Measured by Computed Tomography in Patients With Human Immunodeficiency Virus. Open Forum Infect Dis 3:ofw062
Nou, Eric; Lu, Michael T; Looby, Sara E et al. (2016) Serum oxidized low-density lipoprotein decreases in response to statin therapy and relates independently to reductions in coronary plaque in patients with HIV. AIDS 30:583-90

Showing the most recent 10 out of 117 publications