There is an ongoing need to train outstanding investigators to research the biology of lung diseases incorporating multidisciplinary approaches. This application proposes to develop a training program that combines mentorship from an outstanding faculty with an integrated didactic and research program. To achieve these objectives, we have focused on the following specific goals: 1) To provide stipend support for the development of pre-doctorai and post- doctoral PhD and MD scientists with commitment to an academic career. 2) To provide mentorship by senior investigators. 3) To provide the laboratory environment, training and skilled supervision required for the development of independent investigators. 4) To provide the educational resources in the form of didactic courses, invited speakers and collaborative interactions that will foster the skills required for an independent research career. 5) To create an administrative structure that facilitates the trainee's career progression required to pursue an independent academic career. 6) To protect research trainees from activities not directly related to research that may compete for their time. 7) To establish an ongoing evaluation process for determining whether or not the program is meeting its goals and objectives. The long-term goal of this program is to encourage bright, enthusiastic, well-trained pre-doctoral candidates and post-doctoral MDs and PhDs to pursue careers in lung biology research, make them knowledgeable about the complexities associated with conducting scientifically and ethically sound research, and maximize the likelihood they will develop into independent investigators in this area of investigation. The program builds upon the strengths of current training initiatives in the basic sciences, in translational, public health, and health services research and on the considerable scientific and research training experiences of the faculty participating in our training grant. The initiation of the program comes at a time of substantial growth in the Northwestern University Feinberg School of Medicine (NUFMS) Pulmonary and Critical Care Medicine division research which incorporates the collaboration with outstanding scientists from other departments. All of these factors make NUFSM an ideal site for this T32 NRSA award for research in lung biology.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL076139-08
Application #
8022932
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Colombini-Hatch, Sandra
Project Start
2004-04-01
Project End
2014-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
8
Fiscal Year
2011
Total Cost
$334,296
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Wiese, Kristin M; Coates, Bria M; Ridge, Karen M (2017) The Role of Nucleotide-Binding Oligomerization Domain-Like Receptors in Pulmonary Infection. Am J Respir Cell Mol Biol 57:151-161
Misharin, Alexander V; Morales-Nebreda, Luisa; Reyfman, Paul A et al. (2017) Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med 214:2387-2404
Dong, Biqin; Almassalha, Luay M; Soetikno, Brian T et al. (2017) Stochastic fluorescence switching of nucleic acids under visible light illumination. Opt Express 25:7929-7944
Almassalha, L M; Tiwari, A; Ruhoff, P T et al. (2017) The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression. Sci Rep 7:41061
Reczek, Colleen R; Birsoy, K?vanç; Kong, Hyewon et al. (2017) A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nat Chem Biol 13:1274-1279
Ceco, Ermelinda; Weinberg, Samuel E; Chandel, Navdeep S et al. (2017) Metabolism and Skeletal Muscle Homeostasis in Lung Disease. Am J Respir Cell Mol Biol 57:28-34
McElroy, G S; Chandel, N S (2017) Mitochondria control acute and chronic responses to hypoxia. Exp Cell Res 356:217-222
Jablonski, Renea P; Kim, Seok-Jo; Cheresh, Paul et al. (2017) SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis. FASEB J 31:2520-2532
Walter, James M; Kruser, Jacqueline M; Reyfman, Paul A et al. (2017) Postextubation High-Flow Nasal Cannula Oxygen, Randomized Trial of an ICU Quality Improvement Intervention, and Midodrine during Recovery from Septic Shock. Am J Respir Crit Care Med 195:682-684
Brazee, Patricia L; Soni, Pritin N; Tokhtaeva, Elmira et al. (2017) FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury. Front Immunol 8:623

Showing the most recent 10 out of 106 publications