This application is a competing renewal of a multidisciplinary pre-doctoral training grant in integrative cardiovascular biology at the Medical College of Georgia (MCG). The long-term objective of this program is to train pre-doctoral Ph.D. and M.D./Ph.D. students for independent research careers in integrative cardiovascular biology, utilizing molecular, genetic, cellular, tissue/organ, whole animal and human experimental approaches. This program involves the expertise of 28 faculty in the Departments of Cell Biology &Anatomy, Medicine, Pathology, Pediatrics, Pharmacology &Toxicology, Physiology, Surgery. A majority of these faculty also have appointments or affiliations with the Georgia Prevention Institute, the Institute for Molecular Medicine and Genetics, and the Vascular Biology Center on the MCG campus. The faculty preceptors of the program represent an outstanding group of established integrative cardiac and vascular biologists whose research interests cover five related cardiovascular areas: 1) vascular cell signaling, 2) control of vascular tone, 3) cardiac development, 4) endothelial dysfunction, and 5) prevention of cardiovascular disease. This training grant will be administered through the Vascular Biology Center in the School of Medicine. The program is directed by Dr. David M. Pollock, Program Director and Dr. Jennifer S. Pollock, Program Co- Director, both established investigators. An Internal Advisory Committee of experienced leaders of the graduate program at the Medical College of Georgia will supervise the program. Trainees will be Ph.D. or M.D./Ph.D. graduate students currently enrolled full-time in the Biomedical Sciences Ph.D. program in the Medical College of Georgia School of Graduate Studies. Students will be selected based on their expressed interest in integrative cardiovascular biology and their previous academic performance and research experience. All trainees will be required to participate in didactic training activities, which consist of the first year core curriculum and passing the first qualifying exam;advanced course electives such as Cardiovascular Physiology &Pharmacology and Frontiers in Vascular Biology;courses in Scientific Communications and Research Ethics, and Biostatistics;attendance in one or more departmental seminar series;the cardiovascular journal club;and the annual Graduate Research Day activities. Upon completion of the program, students will be ready to pursue post-doctoral training at premier laboratories as they begin their careers as independent investigators in cardiovascular sciences.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL076146-10
Application #
8436219
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Scott, Jane
Project Start
2004-04-01
Project End
2014-09-30
Budget Start
2013-04-01
Budget End
2014-09-30
Support Year
10
Fiscal Year
2013
Total Cost
$103,650
Indirect Cost
$15,928
Name
Georgia Regents University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912
Heimlich, J Brett; Speed, Joshua S; O'Connor, Paul M et al. (2016) Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species. Br J Pharmacol 173:386-95
Spradley, Frank T; Ho, Dao H; Pollock, Jennifer S (2016) Dahl SS rats demonstrate enhanced aortic perivascular adipose tissue-mediated buffering of vasoconstriction through activation of NOS in the endothelium. Am J Physiol Regul Integr Comp Physiol 310:R286-96
Heimlich, J B; Speed, J S; Bloom, C J et al. (2015) ET-1 increases reactive oxygen species following hypoxia and high-salt diet in the mouse glomerulus. Acta Physiol (Oxf) 213:722-30
Iddings, Jennifer A; Kim, Ki Jung; Zhou, Yiqiang et al. (2015) Enhanced parenchymal arteriole tone and astrocyte signaling protect neurovascular coupling mediated parenchymal arteriole vasodilation in the spontaneously hypertensive rat. J Cereb Blood Flow Metab 35:1127-36
Stallmann-Jorgensen, Inger; Ogbi, Safia; Szasz, Theodora et al. (2015) A Toll-Like Receptor 1/2 Agonist Augments Contractility in Rat Corpus Cavernosum. J Sex Med 12:1722-31
Filosa, Jessica A; Iddings, Jennifer A (2013) Astrocyte regulation of cerebral vascular tone. Am J Physiol Heart Circ Physiol 305:H609-19
Shatanawi, Alia; Romero, Maritza J; Iddings, Jennifer A et al. (2011) Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway. Am J Physiol Cell Physiol 300:C1181-92
Pollock, Jennifer S; Pollock, David M (2011) Endothelin, nitric oxide, and reactive oxygen species in diabetic kidney disease. Contrib Nephrol 172:149-59
Bundy, Vanessa; Johnson, Maribeth; Gutin, Bernard et al. (2011) Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race. J Pediatr Endocrinol Metab 24:119-24
Aggarwal, Saurabh; Gross, Christine; Fineman, Jeffrey R et al. (2010) Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb. Trends Cardiovasc Med 20:238-46

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