This application proposes a novel, integrated program for pre-doctoral training in biostatistics focused on preparing trainees for careers in cardiovascular disease research. The critical shortage of skilled biostatisticians equipped to address ongoing and emerging challenges in this exciting new era of cardiovascular disease research calls for training that formally integrates targeted experience in collaboration in a multidisciplinary environment, mastery of the theoretical underpinnings of statistics required for valid application of sophisticated biostatistical techniques and for research on development of new methodology, and strong emphasis on communication and leadership skills. The program will be a joint effort of the Department of Statistics at North Carolina State University (NCSU) and the Duke Clinical Research Institute (DCRI), capitalizing on an existing partnership between one of the largest graduate programs in statistics in the world and a research institution that is the largest of its kind and home to internationally-known researchers at the forefront of cardiovascular disease research. The five-year program will support up to 5 trainees and will involve rigorous study at NCSU of statistical theory, including probability, inference, linear and other statistical models, measure theory and advanced probability, and advanced statistical inference, and statistical methods, including clinical trials design/analysis, longitudinal data analysis, survival analysis, and cutting-edge special topics;training in fundamental aspects of cardiovascular disease science;course work in research responsibility and ethics;and extensive formal and experiential training in communication and leadership skills. Trainees will be introduced to DCRI cardiovascular disease research gradually, evolving to a full collaborative apprenticeship in which they are integrated as functioning members of DCRI project teams. Through both this apprenticeship and formal courses and seminars, trainees will develop extensive working knowledge and expertise in cardiovascular disease science that will position them to make immediate contributions to cardiovascular disease research upon completion of the program. Trainees will be assigned an inter-institutional mentorship team consisting of primary biostatistician mentors at each site and a secondary clinician mentor at DCRI, who will collaborate in guiding them through all aspects. Dissertation research will involve development and evaluation of novel statistical methodology inspired by challenges encountered in trainees cardiovascular disease research collaborations.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL079896-04
Application #
7620944
Study Section
Special Emphasis Panel (ZHL1-CSR-J (O1))
Program Officer
Silsbee, Lorraine M
Project Start
2006-05-15
Project End
2011-05-14
Budget Start
2009-05-15
Budget End
2010-05-14
Support Year
4
Fiscal Year
2009
Total Cost
$164,690
Indirect Cost
Name
North Carolina State University Raleigh
Department
Biostatistics & Other Math Sci
Type
Schools of Earth Sciences/Natur
DUNS #
042092122
City
Raleigh
State
NC
Country
United States
Zip Code
27695
Pagidipati, Neha J; Mudrick, Daniel W; Chiswell, Karen et al. (2018) Sex differences in long-term outcomes of patients across the spectrum of coronary artery disease. Am Heart J 206:51-60
Siddiqui, Irfan; Rajagopal, Sudarshan; Brucker, Amanda et al. (2018) Clinical and Echocardiographic Predictors of Outcomes in Patients With Pulmonary Hypertension. Am J Cardiol 122:872-878
White, Kyle R; Stefanski, Leonard A; Wu, Yichao (2017) Variable Selection in Kernel Regression Using Measurement Error Selection Likelihoods. J Am Stat Assoc 112:1587-1597
Orgel, Ryan; Wojdyla, Daniel; Huberman, David et al. (2017) Noncentral Nervous System Systemic Embolism in Patients With Atrial Fibrillation: Results From ROCKET AF (Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fi Circ Cardiovasc Qual Outcomes 10:
Harskamp, Ralf E; Alexander, John H; Ferguson Jr, T Bruce et al. (2016) Frequency and Predictors of Internal Mammary Artery Graft Failure and Subsequent Clinical Outcomes: Insights From the Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) IV Trial. Circulation 133:131-8
Pokorney, Sean D; Radder, Christina; Schulte, Phillip J et al. (2016) High-degree atrioventricular block, asystole, and electro-mechanical dissociation complicating non-ST-segment elevation myocardial infarction. Am Heart J 171:25-32
Jagsi, Reshma; Biga, Cathie; Poppas, Athena et al. (2016) Work Activities and Compensation of Male and Female Cardiologists. J Am Coll Cardiol 67:529-41
Mentz, Robert J; Velazquez, Eric J; Metra, Marco et al. (2015) Comparative effectiveness of torsemide versus furosemide in heart failure patients: insights from the PROTECT trial. Future Cardiol 11:585-95
Mentz, Robert J; Metra, Marco; Cotter, Gad et al. (2015) Early vs. late worsening heart failure during acute heart failure hospitalization: insights from the PROTECT trial. Eur J Heart Fail 17:697-706
Mahaffey, Kenneth W; Hager, Rebecca; Wojdyla, Daniel et al. (2015) Meta-analysis of intracranial hemorrhage in acute coronary syndromes: incidence, predictors, and clinical outcomes. J Am Heart Assoc 4:e001512

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