This is our first competing renewal for this institutional training grant in Hematologic and Oncologic Diseases of Childhood at the University of Iowa Children's Hospital which is jointly sponsored by NHLBI and NICHD. We initially proposed to focus on training in translational and clinical research with the intent of recruiting more women and minorities for academic careers. We were highly successful as three of five fellows recruited to date have been women and two have been minority candidates. Moreover, the two female fellows who have """"""""graduated"""""""", one of whom is also a minority trainee, are both in junior faculty positions in Departments of Pediatrics where they are actively engaged in clinical research. We are now asking to continue training physician/scientists who will contribute to improved diagostic, treatment and prevention strategies for children with blood diseases and malignancies. We seek to add one position for a PhD fellow because we have come to realize how important basic scientists are to successful translational and clinical research. We plan to continue to focus on recruiting and training women in our program because, like many pediatric subspecialty training programs, our Department of Pediatrics at Iowa recruits more women than men into residency, but loses most women from the ranks of fellows who obtain subspecialty training and pursue a career in academic medicine. Reversing this loss of talent in academia is crucial to training the next generation of physicians and scientists who will focus on improving care for children with hematologic and oncologic diseases. We therefore propose the following specific aims to accomplish our goals: 1. Expand opportunities for trainees to pursue academic careers with a focus on hematologic and malignant diseases of childhood. 2. Provide trainees with the opportunity to obtain a Master's degree or non-degree certification in either translational or clinical medicine. 3. Recruit and train women and minority candidates for successful careers that will benefit children with hematologic and oncologic disorders.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Iowa
Schools of Medicine
Iowa City
United States
Zip Code
Darbro, Benjamin W; Singh, Rohini; Zimmerman, M Bridget et al. (2016) Autism Linked to Increased Oncogene Mutations but Decreased Cancer Rate. PLoS One 11:e0149041
Niki, Masaru; Nayak, Manasa K; Jin, Hong et al. (2016) Dok-1 negatively regulates platelet integrin ?IIb?3 outside-in signalling and inhibits thrombosis in mice. Thromb Haemost 115:969-78
Baumhover, Nicholas J; Duskey, Jason T; Khargharia, Sanjib et al. (2015) Structure-Activity Relationship of PEGylated Polylysine Peptides as Scavenger Receptor Inhibitors for Non-Viral Gene Delivery. Mol Pharm 12:4321-8
Khargharia, S; Baumhover, N J; Crowley, S T et al. (2014) The uptake mechanism of PEGylated DNA polyplexes by the liver influences gene expression. Gene Ther 21:1021-8
Ontiveros, Evelena P; Halwani, Ahmad; Stunz, Laura L et al. (2014) A new model of LMP1-MYC interaction in B cell lymphoma. Leuk Lymphoma 55:2917-23
Martin, Molly E; Sue O'Dorisio, M; Leverich, Whitney M et al. (2013) ""Click""-cyclized (68)Ga-labeled peptides for molecular imaging and therapy: synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system. Recent Results Cancer Res 194:149-75
Khargharia, Sanjib; Kizzire, Koby; Ericson, Mark D et al. (2013) PEG length and chemical linkage controls polyacridine peptide DNA polyplex pharmacokinetics, biodistribution, metabolic stability and in vivo gene expression. J Control Release 170:325-33
Han, Seong-Su; Son, Dong-Ju; Yun, Hwakyung et al. (2013) Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro. Leuk Res 37:146-54
Yamada, Masaki; Kamberos, Natalie; Grose, Charles (2013) Breakthrough varicella in a cancer patient with persistent varicella antibody after one varicella vaccination. J Pediatr 163:1511-3
Han, Seong-Su; Tompkins, Van S; Son, Dong-Ju et al. (2013) Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells. Biochem Biophys Res Commun 436:660-5

Showing the most recent 10 out of 12 publications