This is our first competing renewal for this institutional training grant in Hematologic and Oncologic Diseases of Childhood at the University of Iowa Children's Hospital which is jointly sponsored by NHLBI and NICHD. We initially proposed to focus on training in translational and clinical research with the intent of recruiting more women and minorities for academic careers. We were highly successful as three of five fellows recruited to date have been women and two have been minority candidates. Moreover, the two female fellows who have "graduated", one of whom is also a minority trainee, are both in junior faculty positions in Departments of Pediatrics where they are actively engaged in clinical research. We are now asking to continue training physician/scientists who will contribute to improved diagostic, treatment and prevention strategies for children with blood diseases and malignancies. We seek to add one position for a PhD fellow because we have come to realize how important basic scientists are to successful translational and clinical research. We plan to continue to focus on recruiting and training women in our program because, like many pediatric subspecialty training programs, our Department of Pediatrics at Iowa recruits more women than men into residency, but loses most women from the ranks of fellows who obtain subspecialty training and pursue a career in academic medicine. Reversing this loss of talent in academia is crucial to training the next generation of physicians and scientists who will focus on improving care for children with hematologic and oncologic diseases. We therefore propose the following specific aims to accomplish our goals: 1. Expand opportunities for trainees to pursue academic careers with a focus on hematologic and malignant diseases of childhood. 2. Provide trainees with the opportunity to obtain a Master's degree or non-degree certification in either translational or clinical medicine. 3. Recruit and train women and minority candidates for successful careers that will benefit children with hematologic and oncologic disorders.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL080070-10
Application #
8695430
Study Section
NHLBI Institutional Training Mechanism Review Committee (NITM)
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Iowa
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Ontiveros, Evelena P; Halwani, Ahmad; Stunz, Laura L et al. (2014) A new model of LMP1-MYC interaction in B cell lymphoma. Leuk Lymphoma 55:2917-23
Martin, Molly E; Sue O'Dorisio, M; Leverich, Whitney M et al. (2013) "Click"-cyclized (68)Ga-labeled peptides for molecular imaging and therapy: synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system. Recent Results Cancer Res 194:149-75
Khargharia, Sanjib; Kizzire, Koby; Ericson, Mark D et al. (2013) PEG length and chemical linkage controls polyacridine peptide DNA polyplex pharmacokinetics, biodistribution, metabolic stability and in vivo gene expression. J Control Release 170:325-33