At the University of Illinois, we seek to train pulmonary and critical care fellows who have completed two years of clinical training and have the aptitude and commitment for two or three additional years of investigative training. We propose to integrates a minimal amount of relevant classroom work with a goal directed mentored research experience that is focused on a scientific body of knowledge related to the role of inflammation and innate immunity in a wide spectrum of lung diseases. We believe that this scientific platform pertains most broadly to a wide variety of lung diseases that share a prominent inflammatory feature and include the very prevalent diseases of asthma, COPD and other tobacco induced lung diseases, interstitial lung disease, and the acute respiratory distress syndrome. By design, we propose a two-track program that blends training in """"""""clinical trials, epidemiology, and outcomes research"""""""" with """"""""translational approaches in cellular and animal models of inflammation"""""""". Candidates accepted to the clinical science track will take four courses in relevant epidemiology and biostatistics and candidates chosen for the basic science track will complete four courses in research methods and integrated biology and physiology. Mentors are selected based on their area of expertise and interests, set of complementary research skills, achievement in extramural funding, and proven record of strong mentorship. All trainees will develop an individualized research program, learn to write grant proposals, and receive career counseling and assistance in academic job placement. The progress of the trainees will be closely monitored by a research advisory committee, internal executive committee, external advisory board, and the principal investigator. The program will be judged successful based on the academic performance of the trainees. A unique aspect of our program is that the clinical and basic tracks will be closely integrated so that individuals in both tracks will develop two separate skill sets that will synergize as a more powerful teamwork approach to the investigation of lung disease. Our program is designed to emphasize novel molecular approaches in an ethical and scientifically responsible environment and has a strong commitment to attracting individuals from underrepresented minorities.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Institutional National Research Service Award (T32)
Project #
5T32HL082547-03
Application #
7618799
Study Section
Special Emphasis Panel (ZHL1-CSR-J (O1))
Program Officer
Colombini-Hatch, Sandra
Project Start
2007-05-01
Project End
2012-04-30
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
3
Fiscal Year
2009
Total Cost
$333,618
Indirect Cost
Name
University of Illinois at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Ayee, Manuela Aseye Ayele; LeMaster, Elizabeth; Teng, Tao et al. (2018) Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force. Biophys J 114:929-938
Karpurapu, Manjula; Lee, Yong Gyu; Qian, Ziqing et al. (2018) Inhibition of nuclear factor of activated T cells (NFAT) c3 activation attenuates acute lung injury and pulmonary edema in murine models of sepsis. Oncotarget 9:10606-10620
Shamaei, Masoud; Mirsaeidi, Mehdi; Baghaei, Parvaneh et al. (2017) Recurrent Drug-Induced Hepatitis in Tuberculosis-Comparison of Two Drug Regimens. Am J Ther 24:e144-e149
Zaidi, Farhan; Lee, Ryan S; Buchcic, Bartosz A et al. (2017) Evaluation and Documentation of Supplemental Oxygen Requirements is Rarely Performed in Patients Hospitalized With COPD. Chronic Obstr Pulm Dis 4:287-296
Ascoli, Christian; Huang, Yue; Schott, Cody et al. (2017) A Circulating Micro-RNA Signature Serves as a Diagnostic and Prognostic Indicator in Sarcoidosis. Am J Respir Cell Mol Biol :
Ayee, Manuela A A; LeMaster, Elizabeth; Shentu, Tzu Pin et al. (2017) Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids. Biophys J 112:325-338
Qian, Feng; Deng, Jing; Wang, Gang et al. (2016) Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases. Curr Protein Pept Sci 17:332-42
Fraidenburg, Dustin R; Machado, Roberto F (2016) Pulmonary hypertension associated with thalassemia syndromes. Ann N Y Acad Sci 1368:127-39
Prieto-Centurion, Valentin; Bracken, Nina; Norwick, Lourdes et al. (2016) Can Commercially Available Pedometers Be Used For Physical Activity Monitoring In Patients With COPD Following Exacerbations? Chronic Obstr Pulm Dis 3:636-642
Omar, Hesham R; Mirsaeidi, Mehdi; Shumac, Jacob et al. (2016) Incidence and predictors of ischemic cerebrovascular stroke among patients on extracorporeal membrane oxygenation support. J Crit Care 32:48-51

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